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Dopamine and the af...
Dopamine and the affective-cognitive gradient in the human striatum studied with multimodal brain imaging
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- Grill, Filip, 1989- (author)
- Umeå universitet,Institutionen för strålningsvetenskaper,Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Rieckmann, Anna, PhD (thesis advisor)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Nyberg, Lars, Professor, 1966- (thesis advisor)
- Umeå universitet,Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Adcock, Alison, PhD (opponent)
- Department of Biological Psychiatry, Duke University School of Medicine, Durham, United States of America
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(creator_code:org_t)
- ISBN 9789178558247
- Umeå : Umeå universitet, 2022
- English 76 s.
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Series: Umeå University medical dissertations, 0346-6612 ; 2189
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Abstract
Subject headings
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- Both dopamine and the dopamine rich brain area, striatum, have been linked to behaviors related to incentives, motor action, and associative processing. Most of the cortex sends projections to the striatum, these connections have been described as a gradient organization representing a repertoire of functional behaviors. Although considerable research efforts have been made on the functions of dopamine, it is still unclear how and when it is released in the striatum in humans and what role it has for everyday behavior.The overarching aim of this thesis is to contribute to our understanding of the role of striatal dopamine release during human behaviors relating to incentive, motor, and associative processing. Using a combination of multimodal brain imaging (positron emission tomography and functional magnetic resonance imaging) as well as cognitive modelling this thesis investigates: how a reproducible striatal response to incentives can be divided into behaviorally relevant components relating to affective and cognitive processes, how striatal dopamine release during motor action represent several component processes of behavior, and also provides evidence that striatal dopamine is released during reward prediction errors in humans. The results are consistent with an affective-cognitive gradient in the striatum and suggest that dopamine release into the striatal gradient might facilitate the integration of component processes into complex representations of behavior. The results of this thesis are based on healthy young individuals, however, aberrant dopamine signaling is a hallmark of several psychiatric and neurological diseases making it crucial to further understand the healthy dopamine system.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- dopamine
- striatum
- incentive
- motor
- associative
- reinforcement learning
- reward prediction error
- positron emission tomography
- functional magnetic resonance imaging
- PET/MR
- cognitive modelling
Publication and Content Type
- vet (subject category)
- dok (subject category)
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