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Determinants of blood acylcarnitine concentrations in healthy individuals of the European Prospective Investigation into Cancer and Nutrition

Wedekind, Roland (author)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, 150 Cours Albert Thomas, Lyon, France
Rothwell, Joseph A. (author)
(CESP), Faculté de Medicine, Université Paris-Saclay, Inserm, Villejuif, France; Institut Gustave Roussy, Villejuif, France
Viallon, Vivian (author)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, 150 Cours Albert Thomas, Lyon, France
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Keski-Rahkonen, Pekka (author)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, 150 Cours Albert Thomas, Lyon, France
Schmidt, Julie A. (author)
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, UK, United Kingdom
Chajes, Veronique (author)
International Agency for Research on Cancer, 150 Cours Albert Thomas, Lyon, France
Katzke, Vna (author)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Johnson, Theron (author)
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
Santucci de Magistris, Maria (author)
A.O.U. Federico II, Naples, Italy
Krogh, Vittorio (author)
Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale Dei Tumori di Milano, Milan, Italy
Amiano, Pilar (author)
Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain; Biodonostia Health Research Institute, Epidemiology of Chronic and Communicable Diseases Group, San Sebastián, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
Sacerdote, Carlotta (author)
Unit of Cancer Epidemiology, Città Della Salute e Della Scienza University-Hospital, Via Santena 7, Turin, Italy
Redondo-Sánchez, Daniel (author)
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria Ibs.GRANADA, Granada, Spain
Huerta, José María (author)
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain
Tjønneland, Anne (author)
Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark
Pokharel, Pratik (author)
Danish Cancer Society Research Center, Copenhagen, Denmark; Institute for Nutrition Research, School of Medical and Health Sciences, Edith Cowan University, WA, Joondalup, Australia
Jakszyn, Paula (author)
Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain; Blanquerna School of Health Sciences, Ramon Llull University, Barcelona, Spain
Tumino, Rosario (author)
Hyblean Association for Epidemiological Research AIRE – ONLUS, Ragusa, Italy
Ardanaz, Eva (author)
Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain
Sandanger, Torkjel M. (author)
Department of Community Medicine, UiT - the Arctic University of Norway, Langnes, Tromsø, Norway
Winkvist, Anna (author)
Umeå universitet,Avdelningen för hållbar hälsa
Hultdin, Johan (author)
Umeå universitet,Klinisk kemi
Schulze, Matthias B. (author)
Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; University of Potsdam, Institute of Nutritional Science, Potsdam, Germany
Weiderpass, Elisabete (author)
International Agency for Research on Cancer, 150 Cours Albert Thomas, Lyon, France
Gunter, Marc J. (author)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, 150 Cours Albert Thomas, Lyon, France
Huybrechts, Inge (author)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, 150 Cours Albert Thomas, Lyon, France
Scalbert, Augustin (author)
Nutrition and Metabolism Branch, International Agency for Research on Cancer, 150 Cours Albert Thomas, Lyon, France
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 (creator_code:org_t)
Elsevier, 2022
2022
English.
In: Clinical Nutrition. - : Elsevier. - 0261-5614 .- 1532-1983. ; 41:8, s. 1735-1745
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Background & aims: Circulating levels of acylcarnitines (ACs) have been associated with the risk of various diseases such as cancer and type 2 diabetes. Diet and lifestyle factors have been shown to influence AC concentrations but a better understanding of their biological, lifestyle and metabolic determinants is needed.Methods: Circulating ACs were measured in blood by targeted (15 ACs) and untargeted metabolomics (50 ACs) in 7770 and 395 healthy participants of the European Prospective Investigation into Cancer and Nutrition (EPIC), respectively. Associations with biological and lifestyle characteristics, dietary patterns, self-reported intake of individual foods, estimated intake of carnitine and fatty acids, and fatty acids in plasma phospholipid fraction and amino acids in blood were assessed.Results: Age, sex and fasting status were associated with the largest proportion of AC variability (partial-r up to 0.19, 0.18 and 0.16, respectively). Some AC species of medium or long-chain fatty acid moiety were associated with the corresponding fatty acids in plasma (partial-r = 0.24) or with intake of specific foods such as dairy foods containing the same fatty acid. ACs of short-chain fatty acid moiety (propionylcarnitine and valerylcarnitine) were moderately associated with concentrations of branched-chain amino acids (partial-r = 0.5). Intake of most other foods and of carnitine showed little association with AC levels.Conclusions: Our results show that determinants of ACs in blood vary according to their fatty acid moiety, and that their concentrations are related to age, sex, diet, and fasting status. Knowledge on their potential determinants may help interpret associations of ACs with disease risk and inform on potential dietary and lifestyle factors that might be modified for disease prevention.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Näringslära (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Nutrition and Dietetics (hsv//eng)

Keyword

Acylcarnitines
Branched-chain amino acids
Diet
Fatty acids
Metabolomics

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ref (subject category)
art (subject category)

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