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Label-free detectio...
Label-free detection and quantification of ultrafine particulate matter in lung and heart of mouse and evaluation of tissue injury
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- Hameed, Saira (author)
- Umeå universitet,Kemiska institutionen,Department of Chemistry, Fudan University, Shanghai, China
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- Pan, Kun (author)
- Department of Environmental Health, School of Public Health and the Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, 130 Dong’an Road, Box 249, Shanghai, China
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- Su, Wenhua (author)
- Department of Optical Science and Engineering, Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), Shanghai Engineering Research Center of Ultra-Precision Optical Manufacturing, Green Photoelectron Platform, Fudan University, 220 Handan Road, Shanghai, China
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- Trupp, Miles (author)
- Umeå universitet,Neurovetenskaper
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- Mi, Lan (author)
- Department of Optical Science and Engineering, Key Laboratory of Micro and Nano Photonic Structures (Ministry of Education), Shanghai Engineering Research Center of Ultra-Precision Optical Manufacturing, Green Photoelectron Platform, Fudan University, 220 Handan Road, Shanghai, China
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- Zhao, Jinzhuo (author)
- Department of Environmental Health, School of Public Health and the Key Laboratory of Public Health Safety, Ministry of Education, Fudan University, 130 Dong’an Road, Box 249, Shanghai, China; IRDR ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan University, Shanghai, China
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(creator_code:org_t)
- 2022-07-26
- 2022
- English.
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In: Particle and Fibre Toxicology. - : BioMed Central (BMC). - 1743-8977. ; 19:1
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https://umu.diva-por... (primary) (Raw object)
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Abstract
Subject headings
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- While it is known that air borne ultrafine particulate matter (PM) may pass through the pulmonary circulation of blood at the alveolar level between lung and heart and cross the air-blood barrier, the mechanism and effects are not completely clear. In this study the imaging method fluorescence lifetime imaging microscopy is adopted for visualization with high spatial resolution and quantification of ultrafine PM particles in mouse lung and heart tissues. The results showed that the median numbers of particles in lung of mice exposed to ultrafine particulate matter of diameter less than 2.5 µm was about 2.0 times more than that in the filtered air (FA)-treated mice, and about 1.3 times more in heart of ultrafine PM-treated mice than in FA-treated mice. Interestingly, ultrafine PM particles were more abundant in heart than lung, likely due to how ultrafine PM particles are cleared by phagocytosis and transport via circulation from lungs. Moreover, heart tissues showed inflammation and amyloid deposition. The component analysis of concentrated airborne ultrafine PM particles suggested traffic exhausts and industrial emissions as predominant sources. Our results suggest association of ultrafine PM exposure to chronic lung and heart tissue injuries. The current study supports the contention that industrial air pollution is one of the causative factors for rising levels of chronic pulmonary and cardiac diseases.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
Keyword
- Fluorescence lifetime imaging microscopy
- Heart
- Injury
- Lung
- Scanning electron microscopy
- Ultrafine PM
Publication and Content Type
- ref (subject category)
- art (subject category)
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