Search: onr:"swepub:oai:DiVA.org:umu-198908" >
Serum concentration...
Serum concentration of extracellular cold-inducible RNA-binding protein is associated with respiratory failure in COVID-19
-
- Schagatay, Felix (author)
- Department of Infectious Diseases, CKF Region Västmanland, Västerås Hospital, Västerås, Sweden
-
- Diamant, Klara (author)
- School of Medical Sciences, Örebro University, Örebro, Sweden
-
- Lidén, Mats, 1976- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Radiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
-
show more...
-
- Edin, Alicia, 1985- (author)
- Umeå universitet,Anestesiologi och intensivvård,Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden
-
- Athlin, Simon, 1971- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,School of Medical Sciences, Örebro University, Örebro, Sweden
-
- Hultgren, Olof, 1970- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Laboratory medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
-
- Ahlm, Clas, 1956- (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Department of Clinical Microbiology, Umeå University, Umeå, Sweden
-
- Forsell, Mattias N. E. (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Department of Clinical Microbiology, Umeå University, Umeå, Sweden
-
- Savilampi, Johanna, 1977- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Anaesthesiology and Intensive Care, Örebro University, Örebro, Sweden
-
- Normark, Johan (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Department of Clinical Microbiology, Umeå University, Umeå, Sweden
-
- Lange, Anna, 1975- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Infectious Diseases, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
-
- Cajander, Sara, 1980- (author)
- Örebro universitet,Institutionen för medicinska vetenskaper,Department of Infectious Diseases, Faculty of Medicine and Health, Örebro University, Örebro, Sweden
-
show less...
-
(creator_code:org_t)
- 2022-07-29
- 2022
- English.
-
In: Frontiers in Immunology. - : Frontiers Media S.A.. - 1664-3224. ; 13
- Related links:
-
https://doi.org/10.3...
-
show more...
-
https://umu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
https://urn.kb.se/re...
-
show less...
Abstract
Subject headings
Close
- Uncontrolled release of damage-associated molecular patterns (DAMPs) is suggested to be a major trigger for the dysregulated host immune response that leads to severe COVID-19. Cold-inducible RNA-binding protein (CIRP), is a newly identified DAMP that aggravates inflammation and tissue injury, and induces respiratory failure in sepsis. Whether CIRP contributes to the pathogenesis of respiratory failure in COVID-19 has not yet been explored.Aim: To investigate if the concentration of extracellular CIRP (eCIRP) in serum associates with respiratory failure and lung involvement by chest computed tomography (CT) in COVID-19.Methods: Herein we report a prospective observational study of patients with COVID-19 included at two University Hospitals in Sweden between April 2020 and May 2021. Serum from hospitalized patients in Örebro (N=97) were used to assess the association between eCIRP and the level of respiratory support and its correlation with pulmonary involvement on chest CT and inflammatory biomarkers. A cohort of hospitalized and non-hospitalized patients from Umeå (N=78) was used as an external validation cohort. The severity of disease was defined according to the highest degree of respiratory support; mild disease (no oxygen), non-severe hypoxemia (conventional oxygen or high-flow nasal oxygen, HFNO <50% FiO2), and severe hypoxemia (HFNO ≥50% FiO2, mechanical ventilation). Unadjusted and adjusted linear regression was used to evaluate peak eCIRP day 0-4 in respect to severity, age, sex, Charlson comorbidity score, symptom duration, and BMI.Results: Peak eCIRP concentrations were higher in patients with severe hypoxemia and were independently associated with the degree of respiratory support in both cohorts (Örebro; p=0.01, Umeå; p<0.01). The degree of pulmonary involvement measured by CT correlated with eCIRP, rs=0.30, p<0.01 (n=97).Conclusion: High serum levels of eCIRP are associated with acute respiratory failure in COVID-19. Experimental studies are needed to determine if treatments targeting eCIRP reduces the risk of acute respiratory failure in COVID-19.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
Keyword
- CIRP
- COVID-19
- DAMPs
- eCIRP
- inflammation
- severity
- Anaesthesiology
- anestesiologi
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Schagatay, Felix
-
Diamant, Klara
-
Lidén, Mats, 197 ...
-
Edin, Alicia, 19 ...
-
Athlin, Simon, 1 ...
-
Hultgren, Olof, ...
-
show more...
-
Ahlm, Clas, 1956 ...
-
Forsell, Mattias ...
-
Savilampi, Johan ...
-
Normark, Johan
-
Lange, Anna, 197 ...
-
Cajander, Sara, ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Immunology in th ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Rheumatology and ...
- Articles in the publication
-
Frontiers in Imm ...
- By the university
-
Umeå University
-
Örebro University