Search: onr:"swepub:oai:DiVA.org:umu-199386" >
Cigarette Smoking a...
Cigarette Smoking and Endometrial Cancer Risk : observational and Mendelian Randomization Analyses
-
- Dimou, Niki (author)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
-
- Omiyale, Wemimo (author)
- Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
-
- Biessy, Carine (author)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
-
show more...
-
- Viallon, Vivian (author)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
-
- Kaaks, Rudolf (author)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
-
- O'Mara, Tracy A. (author)
- Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, QLD, Brisbane, Australia
-
- Aglago, Elom K. (author)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
-
- Ardanaz, Eva (author)
- Navarra Public Health Institute, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Spain
-
- Bergmann, Manuela M. (author)
- German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany
-
- Bondonno, Nicola P. (author)
- Danish Cancer Society Research Center, Copenhagen, Denmark
-
- Braaten, Tonje (author)
- Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway
-
- Colorado-Yohar, Sandra M. (author)
- CIBER Epidemiología y Salud Pública (CIBERESP), Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia
-
- Crous-Bou, Marta (author)
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO) - Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain; Department of Epidemiology, Harvard T.H. Chan School of Public Health. Boston, MA, United States
-
- Dahm, Christina C. (author)
- Department of Public Health, Aarhus University, Aarhus, Denmark
-
- Fortner, Renée T (author)
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
-
- Gram, Inger T. (author)
- Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway
-
- Harlid, Sophia, 1978- (author)
- Umeå universitet,Obstetrik och gynekologi
-
- Heath, Alicia K. (author)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
-
- Idahl, Annika, 1965- (author)
- Umeå universitet,Obstetrik och gynekologi
-
- Kvaskoff, Marina (author)
- UVSQ, Inserm CESP U1018, Gustave Roussy, Université Paris-Saclay, Villejuif, France
-
- Nøst, Therese H. (author)
- Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway; K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health and Nursing, NTNU, Norwegian University of Science and Technology, Trondheim, Norway
-
- Overvad, Kim (author)
- Department of Public Health, Aarhus University, Aarhus, Denmark
-
- Palli, Domenico (author)
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy
-
- Perez-Cornago, Aurora (author)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
-
- Sacerdote, Carlotta (author)
- Unit of Cancer Epidemiology, Città della Salute e della Scienza University-Hospital, Turin, Italy
-
- Sánchez, Maria-Jose (author)
- Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
-
- Schulze, Matthias B. (author)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Potsdam, Germany
-
- Severi, Gianluca (author)
- UVSQ, Inserm CESP U1018, Gustave Roussy, Université Paris-Saclay, Villejuif, France; Department of Statistics, Computer Science, Applications "G. Parenti", University of Florence, Florence, Italy
-
- Simeon, Vittorio (author)
- Dipartimento di Salute Mentale e Fisica e Medicina Preventiva, University of Naples "L. Vanvitelli", Naples, Italy
-
- Tagliabue, Giovanna (author)
- Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori Via Venezian 1, Milan, Italy
-
- Tjønneland, Anne (author)
- Department of Public Health, University of Copenhagen, Copenhagen, Denmark
-
- Truong, Thérèse (author)
- UVSQ, Inserm CESP U1018, Gustave Roussy, Université Paris-Saclay, Villejuif, France
-
- Tumino, Rosario (author)
- Hyblean Association for Epidemiological Research, Ragusa, Italy
-
- Johansson, Mattias (author)
- Section of Genetics, International Agency for Research on Cancer, Lyon, France
-
- Weiderpass, Elisabete (author)
- Office of the Director, International Agency for Research on Cancer, World Health Organization, Lyon, France
-
- Murphy, Neil (author)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
-
- Gunter, Marc J. (author)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
-
- Lacey, Ben (author)
- Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
-
- Allen, Naomi E. (author)
- Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
-
- Dossus, Laure (author)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France
-
show less...
-
(creator_code:org_t)
- American Association for Cancer Research, 2022
- 2022
- English.
-
In: Cancer Epidemiology, Biomarkers and Prevention. - : American Association for Cancer Research. - 1055-9965 .- 1538-7755. ; 31:9, s. 1839-1848
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://umu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND: Current epidemiologic evidence indicates that smoking is associated with a lower endometrial cancer risk. However, it is unknown if this association is causal or confounded. To further elucidate the role of smoking in endometrial cancer risk, we conducted complementary observational and Mendelian randomization (MR) analyses.METHODS: The observational analyses included 286,415 participants enrolled in the European Prospective Investigation into Cancer and Nutrition and 179,271 participants in the UK Biobank, and multivariable Cox proportional hazards models were used. In two-sample MR analyses, genetic variants robustly associated with lifetime amount of smoking (n = 126 variants) and ever having smoked regularly (n = 112 variants) were selected and their association with endometrial cancer risk (12,906 cancer/108,979 controls from the Endometrial Cancer Association Consortium) was examined.RESULTS: In the observational analysis, lifetime amount of smoking and ever having smoked regularly were associated with a lower endometrial cancer risk. In the MR analysis accounting for body mass index, a genetic predisposition to a higher lifetime amount of smoking was not associated with endometrial cancer risk (OR per 1-SD increment: 1.15; 95% confidence interval: 0.91-1.44). Genetic predisposition to ever having smoked regularly was not associated with risk of endometrial cancer.CONCLUSIONS: Smoking was inversely associated with endometrial cancer in the observational analyses, although unsupported by the MR. Additional studies are required to better understand the possible confounders and mechanisms underlying the observed associations between smoking and endometrial cancer. IMPACT: The results from this analysis indicate that smoking is unlikely to be causally linked with endometrial cancer risk.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Dimou, Niki
-
Omiyale, Wemimo
-
Biessy, Carine
-
Viallon, Vivian
-
Kaaks, Rudolf
-
O'Mara, Tracy A.
-
show more...
-
Aglago, Elom K.
-
Ardanaz, Eva
-
Bergmann, Manuel ...
-
Bondonno, Nicola ...
-
Braaten, Tonje
-
Colorado-Yohar, ...
-
Crous-Bou, Marta
-
Dahm, Christina ...
-
Fortner, Renée T
-
Gram, Inger T.
-
Harlid, Sophia, ...
-
Heath, Alicia K.
-
Idahl, Annika, 1 ...
-
Kvaskoff, Marina
-
Nøst, Therese H.
-
Overvad, Kim
-
Palli, Domenico
-
Perez-Cornago, A ...
-
Sacerdote, Carlo ...
-
Sánchez, Maria-J ...
-
Schulze, Matthia ...
-
Severi, Gianluca
-
Simeon, Vittorio
-
Tagliabue, Giova ...
-
Tjønneland, Anne
-
Truong, Thérèse
-
Tumino, Rosario
-
Johansson, Matti ...
-
Weiderpass, Elis ...
-
Murphy, Neil
-
Gunter, Marc J.
-
Lacey, Ben
-
Allen, Naomi E.
-
Dossus, Laure
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Health Sciences
-
and Public Health Gl ...
- Articles in the publication
-
Cancer Epidemiol ...
- By the university
-
Umeå University