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Variant Polycomb co...
Variant Polycomb complexes in Drosophila consistent with ancient functional diversity
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- Kang, Hyuckjoon (author)
- Division of Genetics, Brigham and Women's Hospital, Boston, United States; Department of Genetics, Harvard Medical School, Boston, United States
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- Cabrera, Janel R. (author)
- Division of Genetics, Brigham and Women's Hospital, Boston, United States; Department of Genetics, Harvard Medical School, Boston, United States; Biology Department, Emmanuel College, Boston, United States
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- Zee, Barry M. (author)
- Division of Genetics, Brigham and Women's Hospital, Boston, United States; Department of Genetics, Harvard Medical School, Boston, United States
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- Kang, Heather A. (author)
- Division of Genetics, Brigham and Women's Hospital, Boston, United States; Department of Genetics, Harvard Medical School, Boston, United States
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- Jobe, Jenny Marie (author)
- Biology Department, Emmanuel College, Boston, United States
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- Hegarty, Maeve B. (author)
- Biology Department, Emmanuel College, Boston, United States
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- Barry, Aurelie E. (author)
- Biology Department, Emmanuel College, Boston, United States
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- Glotov, Alexander (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)
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- Schwartz, Yuri B. (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
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- Kuroda, Mitzi I. (author)
- Division of Genetics, Brigham and Women's Hospital, Boston, United States; Department of Genetics, Harvard Medical School, Boston, United States
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(creator_code:org_t)
- NLM (Medline), 2022
- 2022
- English.
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In: Science Advances. - : NLM (Medline). - 2375-2548. ; 8:36
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Abstract
Subject headings
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- Polycomb group (PcG) mutants were first identified in Drosophila on the basis of their failure to maintain proper Hox gene repression during development. The proteins encoded by the corresponding fly genes mainly assemble into one of two discrete Polycomb repressive complexes: PRC1 or PRC2. However, biochemical analyses in mammals have revealed alternative forms of PRC2 and multiple distinct types of noncanonical or variant PRC1. Through a series of proteomic analyses, we identify analogous PRC2 and variant PRC1 complexes in Drosophila, as well as a broader repertoire of interactions implicated in early development. Our data provide strong support for the ancient diversity of PcG complexes and a framework for future analysis in a longstanding and versatile genetic system.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Kang, Hyuckjoon
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Cabrera, Janel R ...
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Zee, Barry M.
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Kang, Heather A.
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Jobe, Jenny Mari ...
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Hegarty, Maeve B ...
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show more...
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Barry, Aurelie E ...
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Glotov, Alexande ...
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Schwartz, Yuri B ...
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Kuroda, Mitzi I.
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
- Articles in the publication
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Science Advances
- By the university
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Umeå University