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  • Kang, HyuckjoonDivision of Genetics, Brigham and Women's Hospital, Boston, United States; Department of Genetics, Harvard Medical School, Boston, United States (author)

Variant Polycomb complexes in Drosophila consistent with ancient functional diversity

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • NLM (Medline),2022
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-199459
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-199459URI
  • https://doi.org/10.1126/sciadv.add0103DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Polycomb group (PcG) mutants were first identified in Drosophila on the basis of their failure to maintain proper Hox gene repression during development. The proteins encoded by the corresponding fly genes mainly assemble into one of two discrete Polycomb repressive complexes: PRC1 or PRC2. However, biochemical analyses in mammals have revealed alternative forms of PRC2 and multiple distinct types of noncanonical or variant PRC1. Through a series of proteomic analyses, we identify analogous PRC2 and variant PRC1 complexes in Drosophila, as well as a broader repertoire of interactions implicated in early development. Our data provide strong support for the ancient diversity of PcG complexes and a framework for future analysis in a longstanding and versatile genetic system.

Subject headings and genre

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  • Cabrera, Janel R.Division of Genetics, Brigham and Women's Hospital, Boston, United States; Department of Genetics, Harvard Medical School, Boston, United States; Biology Department, Emmanuel College, Boston, United States (author)
  • Zee, Barry M.Division of Genetics, Brigham and Women's Hospital, Boston, United States; Department of Genetics, Harvard Medical School, Boston, United States (author)
  • Kang, Heather A.Division of Genetics, Brigham and Women's Hospital, Boston, United States; Department of Genetics, Harvard Medical School, Boston, United States (author)
  • Jobe, Jenny MarieBiology Department, Emmanuel College, Boston, United States (author)
  • Hegarty, Maeve B.Biology Department, Emmanuel College, Boston, United States (author)
  • Barry, Aurelie E.Biology Department, Emmanuel College, Boston, United States (author)
  • Glotov, AlexanderUmeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)(Swepub:umu)algl0008 (author)
  • Schwartz, Yuri B.Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)(Swepub:umu)yusc0002 (author)
  • Kuroda, Mitzi I.Division of Genetics, Brigham and Women's Hospital, Boston, United States; Department of Genetics, Harvard Medical School, Boston, United States (author)
  • Division of Genetics, Brigham and Women's Hospital, Boston, United States; Department of Genetics, Harvard Medical School, Boston, United StatesDivision of Genetics, Brigham and Women's Hospital, Boston, United States; Department of Genetics, Harvard Medical School, Boston, United States; Biology Department, Emmanuel College, Boston, United States (creator_code:org_t)

Related titles

  • In:Science Advances: NLM (Medline)8:362375-2548

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