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Distinctive exercis...
Distinctive exercise-induced inflammatory response and exerkine induction in skeletal muscle of people with type 2 diabetes
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- Pillon, Nicolas J. (author)
- Karolinska Institutet
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- Smith, Jonathon A B (author)
- Karolinska Institutet
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- Alm, Petter S. (author)
- Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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- Chibalin, Alexander V. (author)
- Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
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- Alhusen, Julia (author)
- Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
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- Arner, Erik (author)
- RIKEN Center for Integrative Medical Sciences, Kanagawa, Yokohama, Japan
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- Carninci, Piero (author)
- RIKEN Center for Integrative Medical Sciences, Kanagawa, Yokohama, Japan
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- Fritz, Tomas (author)
- Centre for Family and Community Medicine, Karolinska Institutet, Huddinge, Sweden
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- Otten, Julia, 1973- (author)
- Umeå universitet,Avdelningen för medicin
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- Olsson, Tommy (author)
- Umeå universitet,Avdelningen för medicin
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- van Doorslaer de Ten Ryen, Sophie (author)
- Institute of Neuroscience, UCLouvain, Louvain-la-Neuve, Belgium
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- Deldicque, Louise (author)
- Institute of Neuroscience, UCLouvain, Louvain-la-Neuve, Belgium
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- Caidahl, Kenneth (author)
- Karolinska Institutet
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- Wallberg-Henriksson, Harriet (author)
- Karolinska Institutet
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- Krook, Anna (author)
- Karolinska Institutet
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- Zierath, Juleen R. (author)
- Karolinska Institutet
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(creator_code:org_t)
- NLM (Medline), 2022
- 2022
- English.
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In: Science Advances. - : NLM (Medline). - 2375-2548. ; 8:36
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Abstract
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- Mechanistic insights into the molecular events by which exercise enhances the skeletal muscle phenotype are lacking, particularly in the context of type 2 diabetes. Here, we unravel a fundamental role for exercise-responsive cytokines (exerkines) on skeletal muscle development and growth in individuals with normal glucose tolerance or type 2 diabetes. Acute exercise triggered an inflammatory response in skeletal muscle, concomitant with an infiltration of immune cells. These exercise effects were potentiated in type 2 diabetes. In response to contraction or hypoxia, cytokines were mainly produced by endothelial cells and macrophages. The chemokine CXCL12 was induced by hypoxia in endothelial cells, as well as by conditioned medium from contracted myotubes in macrophages. We found that CXCL12 was associated with skeletal muscle remodeling after exercise and differentiation of cultured muscle. Collectively, acute aerobic exercise mounts a noncanonical inflammatory response, with an atypical production of exerkines, which is potentiated in type 2 diabetes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Fysiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Physiology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Pillon, Nicolas ...
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Smith, Jonathon ...
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Alm, Petter S.
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Chibalin, Alexan ...
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Alhusen, Julia
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Arner, Erik
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show more...
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Carninci, Piero
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Fritz, Tomas
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Otten, Julia, 19 ...
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Olsson, Tommy
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van Doorslaer de ...
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Deldicque, Louis ...
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Caidahl, Kenneth
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Wallberg-Henriks ...
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Krook, Anna
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Zierath, Juleen ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Physiology
- Articles in the publication
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Science Advances
- By the university
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Umeå University
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Karolinska Institutet