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Pan-cancer analysis...
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Breeur, MarieInternational Agency for Research on Cancer, World Health Organization
(author)
Pan-cancer analysis of pre-diagnostic blood metabolite concentrations in the European Prospective Investigation into Cancer and Nutrition
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-10-19
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BioMed Central (BMC),2022
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-200663
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-200663URI
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https://doi.org/10.1186/s12916-022-02553-4DOI
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https://lup.lub.lu.se/record/821f045b-0aa5-4df0-91e3-54c8563b2479URI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Background: Epidemiological studies of associations between metabolites and cancer risk have typically focused on specific cancer types separately. Here, we designed a multivariate pan-cancer analysis to identify metabolites potentially associated with multiple cancer types, while also allowing the investigation of cancer type-specific associations.Methods: We analysed targeted metabolomics data available for 5828 matched case-control pairs from cancer-specific case-control studies on breast, colorectal, endometrial, gallbladder, kidney, localized and advanced prostate cancer, and hepatocellular carcinoma nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. From pre-diagnostic blood levels of an initial set of 117 metabolites, 33 cluster representatives of strongly correlated metabolites and 17 single metabolites were derived by hierarchical clustering. The mutually adjusted associations of the resulting 50 metabolites with cancer risk were examined in penalized conditional logistic regression models adjusted for body mass index, using the data-shared lasso penalty.Results: Out of the 50 studied metabolites, (i) six were inversely associated with the risk of most cancer types: glutamine, butyrylcarnitine, lysophosphatidylcholine a C18:2, and three clusters of phosphatidylcholines (PCs); (ii) three were positively associated with most cancer types: proline, decanoylcarnitine, and one cluster of PCs; and (iii) 10 were specifically associated with particular cancer types, including histidine that was inversely associated with colorectal cancer risk and one cluster of sphingomyelins that was inversely associated with risk of hepatocellular carcinoma and positively with endometrial cancer risk.Conclusions: These results could provide novel insights for the identification of pathways for cancer development, in particular those shared across different cancer types.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Ferrari, PietroInternational Agency for Research on Cancer, World Health Organization
(author)
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Dossus, LaureInternational Agency for Research on Cancer, World Health Organization
(author)
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Jenab, MazdaInternational Agency for Research on Cancer, World Health Organization
(author)
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Johansson, MattiasInternational Agency for Research on Cancer, World Health Organization
(author)
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Rinaldi, SabinaInternational Agency for Research on Cancer, World Health Organization
(author)
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Travis, Ruth C.University of Oxford
(author)
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His, MathildeInternational Agency for Research on Cancer, World Health Organization
(author)
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Key, Tim J.University of Oxford
(author)
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Schmidt, Julie A.Aarhus University Hospital,University of Oxford
(author)
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Overvad, KimAarhus University
(author)
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Tjønneland, AnneDanish Cancer Society
(author)
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Kyrø, CecilieDanish Cancer Society
(author)
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Rothwell, Joseph A.Versailles Saint-Quentin-en-Yvelines University
(author)
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Laouali, NasserVersailles Saint-Quentin-en-Yvelines University
(author)
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Severi, GianlucaVersailles Saint-Quentin-en-Yvelines University
(author)
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Kaaks, RudolfGerman Cancer Research Centre
(author)
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Katzke, VerenaGerman Cancer Research Centre
(author)
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Schulze, Matthias B.German Institute of Human Nutrition
(author)
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Eichelmann, FabianGerman Institute of Human Nutrition,German Center for Diabetes Research
(author)
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Palli, DomenicoInstitute for Cancer Research, Prevention and Clinical Network (ISPRO)
(author)
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Grioni, SaraIstituto Nazionale dei Tumori
(author)
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Panico, SalvatoreUniversity of Naples Federico II
(author)
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Tumino, Rosario
(author)
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Sacerdote, CarlottaCitta' della Salute e della Scienza Hospital-University of Turin
(author)
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Bueno-de-Mesquita, BasNational Institute for Public Health and the Environment (RIVM)
(author)
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Olsen, Karina StandahlUiT The Arctic University of Norway, Tromsø
(author)
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Sandanger, Torkjel ManningUiT The Arctic University of Norway, Tromsø
(author)
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Nøst, Therese HaugdahlUiT The Arctic University of Norway, Tromsø
(author)
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Quirós, J. RamónPublic Health Directorate
(author)
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Bonet, CatalinaBellvitge University Hospital-IDIBELL
(author)
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Barranco, Miguel RodríguezAndalusian School Of Public Health (EASP),CIBER Epidemiology and Public Health (CIBERESP)
(author)
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Chirlaque, María-DoloresCIBER Epidemiology and Public Health (CIBERESP),University of Murcia
(author)
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Ardanaz, EvaHealth Research Institute of Navarra (IDISNA),CIBER Epidemiology and Public Health (CIBERESP)(Swepub:lu)extLU-05
(author)
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Sandsveden, MalteLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Surgery,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments(Swepub:lu)ma6468sa
(author)
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Manjer, JonasLund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Surgery,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital(Swepub:lu)smi-jma
(author)
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Vidman, LindaUmeå University,Umeå universitet,Onkologi(Swepub:umu)livi0018
(author)
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Rentoft, MatildaUmeå University,Umeå universitet,Onkologi(Swepub:umu)maaret01
(author)
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Muller, DavidImperial College London
(author)
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Tsilidis, KostasImperial College London
(author)
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Heath, Alicia K.Imperial College London
(author)
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Keun, HectorImperial College London
(author)
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Adamski, JerzyUniversity of Ljubljana,Helmholtz Zentrum München,National University of Singapore
(author)
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Keski-Rahkonen, PekkaInternational Agency for Research on Cancer, World Health Organization
(author)
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Scalbert, AugustinInternational Agency for Research on Cancer, World Health Organization
(author)
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Gunter, Marc J.International Agency for Research on Cancer, World Health Organization
(author)
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Viallon, VivianInternational Agency for Research on Cancer, World Health Organization
(author)
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International Agency for Research on Cancer, World Health OrganizationUniversity of Oxford
(creator_code:org_t)
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In:BMC Medicine: BioMed Central (BMC)20:11741-7015
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- By the author/editor
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Breeur, Marie
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Ferrari, Pietro
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Dossus, Laure
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Jenab, Mazda
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Johansson, Matti ...
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Rinaldi, Sabina
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Travis, Ruth C.
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His, Mathilde
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Key, Tim J.
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Schmidt, Julie A ...
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Overvad, Kim
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Tjønneland, Anne
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Kyrø, Cecilie
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Rothwell, Joseph ...
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Laouali, Nasser
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Severi, Gianluca
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Kaaks, Rudolf
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Katzke, Verena
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Schulze, Matthia ...
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Eichelmann, Fabi ...
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Palli, Domenico
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Grioni, Sara
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Panico, Salvator ...
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Tumino, Rosario
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Sacerdote, Carlo ...
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Bueno-de-Mesquit ...
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Olsen, Karina St ...
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Sandanger, Torkj ...
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Nøst, Therese Ha ...
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Quirós, J. Ramón
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Bonet, Catalina
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Barranco, Miguel ...
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Chirlaque, María ...
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Ardanaz, Eva
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Sandsveden, Malt ...
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Manjer, Jonas
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Vidman, Linda
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Rentoft, Matilda
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Muller, David
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Tsilidis, Kostas
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Heath, Alicia K.
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Keun, Hector
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Adamski, Jerzy
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Keski-Rahkonen, ...
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Gunter, Marc J.
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Cancer and Oncol ...
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BMC Medicine
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Umeå University
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Lund University