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A retrospective ana...
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Eriksson, VictoriaUmeå universitet,Urologi och andrologi,Umea Univ, Sweden
(author)
A retrospective analysis of the de ritis ratio in muscle invasive bladder cancer, with focus on tumor response and long-term survival in patients receiving neoadjuvant chemotherapy and in chemo naïve cystectomy patients : a study of a clinical multicentre database
- Article/chapterEnglish2022
Publisher, publication year, extent ...
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2022-10-27
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MDPI,2022
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-201225
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-201225URI
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https://doi.org/10.3390/jpm12111769DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-190220URI
Supplementary language notes
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Funding Agencies|Swedish Research Council [Bas-ALF/VLL RV-848051]
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Background: A high pre-treatment De Ritis ratio, the aspartate transaminase/alanine aminotransferase ratio, has been suggested to be of prognostic value for mortality in muscle-invasive bladder cancer (MIBC). Our purpose was to evaluate if a high ratio was associated with mortality and downstaging. Methods: A total of 347 Swedish patients with clinically staged T2-T4aN0M0, with administered neoadjuvant chemotherapy (NAC) or eligible for NAC and undergoing radical cystectomy (RC) 2009–2021, were retrospectively evaluated with a low ratio < 1.3 vs. high ratio > 1.3, by Log Rank test, Cox regression and Mann–Whitney U-test (MWU), SPSS 27. Results: Patients with a high ratio had a decrease of up to 3 years in disease-free survival (DFS), cancer-specific survival (CSS) and overall survival (OS) (p = 0.009, p = 0.004 and p = 0.009) and 5 years in CSS and OS (p = 0.019 and p = 0.046). A high ratio was associated with increased risk of mortality, highest in DFS (HR, 1.909; 95% CI, 1.265–2.880; p = 0.002). No significant relationship between downstaging and a high ratio existed (p = 0.564 MWU). Conclusion: A high pre-treatment De Ritis ratio is on a population level, associated with increased mortality post-RC in endpoints DFS, CSS and OS. Associations decrease over time and require further investigations to determine how strong the associations are as meaningful prognostic markers for long-term mortality in MIBC. The ratio is not suitable for downstaging-prediction.
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Holmkvist, OscarUmeå universitet,Urologi och andrologi,Umea Univ, Sweden
(author)
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Huge, YlvaLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland(Swepub:liu)ylvhu61
(author)
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Johansson, MarkusDepartment of Surgery, Division of Urology, Sundsvall-Härnösand County Hospital, Sundsvall, Sweden,Sundsvall Harnosand Cty Hosp, Sweden
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Alamdari, FarhoodDepartment of Urology, Västmanland Hospital, Västerås, Sweden,Vastmanland Hosp, Sweden
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Svensson, Johan,1978-Umeå universitet,Statistik,Umea Univ, Sweden(Swepub:umu)josv0027
(author)
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Aljabery, FirasLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland(Swepub:liu)firab05
(author)
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Sherif, AmirUmeå universitet,Urologi och andrologi,Umea Univ, Sweden(Swepub:umu)amsh0008
(author)
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Umeå universitetUrologi och andrologi
(creator_code:org_t)
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In:Journal of Personalized Medicine: MDPI12:112075-4426
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