Sökning: onr:"swepub:oai:DiVA.org:umu-201225" > A retrospective ana...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 04951naa a2200541 4500 | |
001 | oai:DiVA.org:umu-201225 | |
003 | SwePub | |
008 | 221205s2022 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:liu-190220 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2012252 URI |
024 | 7 | a https://doi.org/10.3390/jpm121117692 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1902202 URI |
040 | a (SwePub)umud (SwePub)liu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Eriksson, Victoriau Umeå universitet,Urologi och andrologi,Umea Univ, Sweden4 aut0 (Swepub:umu)vier0022 |
245 | 1 0 | a A retrospective analysis of the de ritis ratio in muscle invasive bladder cancer, with focus on tumor response and long-term survival in patients receiving neoadjuvant chemotherapy and in chemo naïve cystectomy patients :b a study of a clinical multicentre database |
264 | c 2022-10-27 | |
264 | 1 | b MDPI,c 2022 |
338 | a electronic2 rdacarrier | |
500 | a Funding Agencies|Swedish Research Council [Bas-ALF/VLL RV-848051] | |
520 | a Background: A high pre-treatment De Ritis ratio, the aspartate transaminase/alanine aminotransferase ratio, has been suggested to be of prognostic value for mortality in muscle-invasive bladder cancer (MIBC). Our purpose was to evaluate if a high ratio was associated with mortality and downstaging. Methods: A total of 347 Swedish patients with clinically staged T2-T4aN0M0, with administered neoadjuvant chemotherapy (NAC) or eligible for NAC and undergoing radical cystectomy (RC) 2009–2021, were retrospectively evaluated with a low ratio < 1.3 vs. high ratio > 1.3, by Log Rank test, Cox regression and Mann–Whitney U-test (MWU), SPSS 27. Results: Patients with a high ratio had a decrease of up to 3 years in disease-free survival (DFS), cancer-specific survival (CSS) and overall survival (OS) (p = 0.009, p = 0.004 and p = 0.009) and 5 years in CSS and OS (p = 0.019 and p = 0.046). A high ratio was associated with increased risk of mortality, highest in DFS (HR, 1.909; 95% CI, 1.265–2.880; p = 0.002). No significant relationship between downstaging and a high ratio existed (p = 0.564 MWU). Conclusion: A high pre-treatment De Ritis ratio is on a population level, associated with increased mortality post-RC in endpoints DFS, CSS and OS. Associations decrease over time and require further investigations to determine how strong the associations are as meaningful prognostic markers for long-term mortality in MIBC. The ratio is not suitable for downstaging-prediction. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a clinical decision rules | |
653 | a cystectomy | |
653 | a neoadjuvant therapy | |
653 | a prognosis | |
653 | a urinary bladder neoplasms | |
700 | 1 | a Holmkvist, Oscaru Umeå universitet,Urologi och andrologi,Umea Univ, Sweden4 aut |
700 | 1 | a Huge, Ylvau Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland4 aut0 (Swepub:liu)ylvhu61 |
700 | 1 | a Johansson, Markusu Department of Surgery, Division of Urology, Sundsvall-Härnösand County Hospital, Sundsvall, Sweden,Sundsvall Harnosand Cty Hosp, Sweden4 aut |
700 | 1 | a Alamdari, Farhoodu Department of Urology, Västmanland Hospital, Västerås, Sweden,Vastmanland Hosp, Sweden4 aut |
700 | 1 | a Svensson, Johan,d 1978-u Umeå universitet,Statistik,Umea Univ, Sweden4 aut0 (Swepub:umu)josv0027 |
700 | 1 | a Aljabery, Firasu Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland4 aut0 (Swepub:liu)firab05 |
700 | 1 | a Sherif, Amiru Umeå universitet,Urologi och andrologi,Umea Univ, Sweden4 aut0 (Swepub:umu)amsh0008 |
710 | 2 | a Umeå universitetb Urologi och andrologi4 org |
773 | 0 | t Journal of Personalized Medicined : MDPIg 12:11q 12:11x 2075-4426 |
856 | 4 | u https://doi.org/10.3390/jpm12111769y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1716118/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:1714604/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-201225 |
856 | 4 8 | u https://doi.org/10.3390/jpm12111769 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-190220 |
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
Kopiera och spara länken för att återkomma till aktuell vy