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Pre-diagnostic circ...
Pre-diagnostic circulating resistin concentrations are not associated with colorectal cancer risk in the european prospective investigation into cancer and nutrition study
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- Pham, Thu-Thi (author)
- Molecular Epidemiology Research Group, Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany
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- Nimptsch, Katharina (author)
- Molecular Epidemiology Research Group, Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany
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- Aleksandrova, Krasimira (author)
- Department of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology—BIPS, Bremen, Germany; Faculty of Human and Health Sciences, University of Bremen, Bremen, Germany
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- Jenab, Mazda (author)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), World Health Organization, 150 Cours Albert Thomas, Lyon, France
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- Reichmann, Robin (author)
- Department of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology—BIPS, Bremen, Germany
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- Wu, Kana (author)
- Department of Nutrition, Harvard T.H. Chan School of Public Health, MA, Boston, United States
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- Tjønneland, Anne (author)
- Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark
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- Kyrø, Cecilie (author)
- Danish Cancer Society Research Center, Copenhagen, Denmark
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- Schulze, Matthias B. (author)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
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- Kaaks, Rudolf (author)
- Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Katzke, Verena (author)
- Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Palli, Domenico (author)
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy
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- Pasanisi, Fabrizio (author)
- Dipartimento di Medicina Clinica E Chirurgia, Federico Ii University, Naples, Italy
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- Ricceri, Fulvio (author)
- Centre for Biostatistics, Epidemiology, and Public Health (C-BEPH), Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy; Unit of Epidemiology, Regional Health Service ASL TO3, Grugliasco, Italy
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- Tumino, Rosario (author)
- Hyblean Association for Epidemiological Research, AIRE ONLUS, Ragusa, Italy
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- Krogh, Vittorio (author)
- Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Via Venezian 1, Milan, Italy
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- Roodhart, Jeanine (author)
- Department of Medical Oncology, UMC Utrecht, Utrecht, Netherlands
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- Castilla, Jesús (author)
- Navarra Public Health Institute—IdiSNA, Pamplona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain
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- Sánchez, Maria-Jose (author)
- CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain; Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain
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- Colorado-Yohar, Sandra Milena (author)
- CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia
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- Harbs, Justin (author)
- Umeå universitet,Onkologi
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- Rutegård, Martin, 1982- (author)
- Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Kirurgi
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- Papier, Keren (author)
- Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom
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- Aglago, Elom K. (author)
- Department of Epidemiology and Biostatistics, Imperial College London, London, United Kingdom
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- Dimou, Niki (author)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), World Health Organization, 150 Cours Albert Thomas, Lyon, France
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- Mayen-Chacon, Ana-Lucia (author)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), World Health Organization, 150 Cours Albert Thomas, Lyon, France
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- Weiderpass, Elisabete (author)
- International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Pischon, Tobias (author)
- Molecular Epidemiology Research Group, Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany; Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin, Germany; Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Biobank Technology Platform, Berlin, Germany; Berlin Institute of Health, Charité-Universitätsmedizin Berlin, Core Facility Biobank, Berlin, Germany
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(creator_code:org_t)
- 2022-11-09
- 2022
- English.
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In: Cancers. - : MDPI. - 2072-6694. ; 14:22
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Abstract
Subject headings
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- Resistin is a polypeptide implicated in inflammatory processes, and as such could be linked to colorectal carcinogenesis. In case-control studies, higher resistin levels have been found in colorectal cancer (CRC) patients compared to healthy individuals. However, evidence for the association between pre-diagnostic resistin and CRC risk is scarce. We investigated pre-diagnostic resistin concentrations and CRC risk within the European Prospective Investigation into Cancer and Nutrition using a nested case-control study among 1293 incident CRC-diagnosed cases and 1293 incidence density-matched controls. Conditional logistic regression models controlled for matching factors (age, sex, study center, fasting status, and women-related factors in women) and potential confounders (education, dietary and lifestyle factors, body mass index (BMI), BMI-adjusted waist circumference residuals) were used to estimate relative risks (RRs) and 95% confidence intervals (CIs) for CRC. Higher circulating resistin concentrations were not associated with CRC (RR per doubling resistin, 1.11; 95% CI 0.94–1.30; p = 0.22). There were also no associations with CRC subgroups defined by tumor subsite or sex. However, resistin was marginally associated with a higher CRC risk among participants followed-up maximally two years, but not among those followed-up after more than two years. We observed no substantial correlation between baseline circulating resistin concentrations and adiposity measures (BMI, waist circumference), adipokines (adiponectin, leptin), or metabolic and inflammatory biomarkers (C-reactive protein, C-peptide, high-density lipoprotein cholesterol, reactive oxygen metabolites) among controls. In this large-scale prospective cohort, there was little evidence of an association between baseline circulating resistin concentrations and CRC risk in European men and women.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- colorectal cancer
- inflammation
- pre-diagnostic resistin
- prospective
- risk
Publication and Content Type
- ref (subject category)
- art (subject category)
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Pham, Thu-Thi
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Nimptsch, Kathar ...
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Aleksandrova, Kr ...
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Jenab, Mazda
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Reichmann, Robin
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Wu, Kana
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Tjønneland, Anne
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Kyrø, Cecilie
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Schulze, Matthia ...
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Kaaks, Rudolf
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Katzke, Verena
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Palli, Domenico
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Pasanisi, Fabriz ...
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Ricceri, Fulvio
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Tumino, Rosario
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Krogh, Vittorio
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Roodhart, Jeanin ...
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Castilla, Jesús
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Sánchez, Maria-J ...
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Colorado-Yohar, ...
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Harbs, Justin
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Rutegård, Martin ...
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Papier, Keren
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Aglago, Elom K.
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Dimou, Niki
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Mayen-Chacon, An ...
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Weiderpass, Elis ...
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Pischon, Tobias
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- MEDICAL AND HEALTH SCIENCES
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Cancers
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Umeå University