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Longitudinal stabil...
Longitudinal stability in working memory and frontal activity in relation to general brain maintenance
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- Nyberg, Lars, 1966- (author)
- Umeå universitet,Diagnostisk radiologi,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Karalija, Nina, 1984- (author)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Papenberg, Goran (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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- Salami, Alireza (author)
- Karolinska Institutet,Stockholms universitet,Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI),Aging Research Center, Karolinska Institutet & Stockholm University, Tomtebodavägen 18A, Stockholm, Sweden,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Umeå University, Sweden
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- Andersson, Micael (author)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Pedersen, Robin (author)
- Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB),Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Vikner, Tomas (author)
- Umeå universitet,Radiofysik,Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Garrett, Douglas D. (author)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Lentzeallee 94, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, Lentzeallee 94, Berlin, Germany
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- Riklund, Katrine, MD, PhD, Professor, 1963- (author)
- Umeå universitet,Diagnostisk radiologi,Umeå centrum för funktionell hjärnavbildning (UFBI)
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- Wåhlin, Anders (author)
- Umeå universitet,Radiofysik,Umeå centrum för funktionell hjärnavbildning (UFBI),Institutionen för tillämpad fysik och elektronik
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- Lövdén, Martin, 1972 (author)
- Gothenburg University,Göteborgs universitet,Karolinska Institutet,Psykologiska institutionen,Department of Psychology
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- Lindenberger, Ulman (author)
- Center for Lifespan Psychology, Max Planck Institute for Human Development, Lentzeallee 94, Berlin, Germany; Max Planck, UCL Centre for Computational Psychiatry and Ageing Research, Lentzeallee 94, Berlin, Germany
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- Bäckman, Lars (author)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
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(creator_code:org_t)
- 2022-12-05
- 2022
- English.
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In: Scientific Reports. - : Springer Nature. - 2045-2322. ; 12:1
- Related links:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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Abstract
Subject headings
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- Cognitive functions are well-preserved for some older individuals, but the underlying brain mechanisms remain disputed. Here, 5-year longitudinal 3-back in-scanner and offline data classified individuals in a healthy older sample (baseline age = 64–68 years) into having stable or declining working-memory (WM). Consistent with a vital role of the prefrontal cortex (PFC), WM stability or decline was related to maintained or reduced longitudinal PFC functional responses. Subsequent analyses of imaging markers of general brain maintenance revealed higher levels in the stable WM group on measures of neurotransmission and vascular health. Also, categorical and continuous analyses showed that rate of WM decline was related to global (ventricles) and local (hippocampus) measures of neuronal integrity. Thus, our findings support a role of the PFC as well as general brain maintenance in explaining heterogeneity in longitudinal WM trajectories in aging.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology -- Psychology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Nyberg, Lars, 19 ...
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Karalija, Nina, ...
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Papenberg, Goran
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Salami, Alireza
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Andersson, Micae ...
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Pedersen, Robin
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show more...
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Vikner, Tomas
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Garrett, Douglas ...
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Riklund, Katrine ...
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Wåhlin, Anders
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Lövdén, Martin, ...
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Lindenberger, Ul ...
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Bäckman, Lars
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Other Medical an ...
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and Gerontology spec ...
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- SOCIAL SCIENCES
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SOCIAL SCIENCES
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and Psychology
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and Psychology
- Articles in the publication
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Scientific Repor ...
- By the university
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Umeå University
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Stockholm University
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Karolinska Institutet
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University of Gothenburg