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  • Sa'idu, H.Department of Medicine, Bayero University; Department of Medicine, Murtala Mohammed Specialist Hospital, Kano, Nigeria (author)

Influence of systolic blood pressure on outcomes in Nigerians with peripartum cardiomyopathy

  • Article/chapterEnglish2022

Publisher, publication year, extent ...

  • Wolters Kluwer,2022
  • electronicrdacarrier

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  • LIBRIS-ID:oai:DiVA.org:umu-202072
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-202072URI
  • https://doi.org/10.4103/njcp.njcp_2005_21DOI

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  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Background: The relationship between blood pressure (BP) trajectories and outcomes in patients with peripartum cardiomyopathy (PPCM) is not clear.Aim: The study aimed to assess the clinical features and outcomes (all-cause mortality and unrecovered left ventricular [LV] systolic function) of PPCM patients grouped according to their baseline systolic BP (SBP).Patients and Methods: PPCM patients presenting to 14 tertiary hospitals in Nigeria were consecutively recruited between June 2017 and March 2018 and then followed up till March 2019. SBP at first presentation was used to categorize the patients into seven groups: <90, 90-99, 100-109, 110-119, 120-129, 130-139, and ≥140 mmHg. Unrecovered LV systolic function was defined as echocardiographic LV ejection fraction (LVEF) below 55% at the last profiling.Results: Two hundred and twenty-seven patients were recruited and followed up for a median of 18 months. Of these, 4.0% had <90 mmHg, 16.3% had 90-99 mmHg, 24.7% had 100-109 mmHg, 24.7% had 110-119 mmHg, 18.5% had 120-129 mmHg, 7.5% had 130-139 mmHg, and 4.4% had ≥140 mmHg of SBP at presentation. The highest frequency of all-cause mortality was recorded among patients with SBP ≤90 mmHg (30.8%) followed by those with 90-99 mmHg (20.5%) (P = 0.076), while unrecovered LV systolic function did not differ significantly between the groups (P = 0.659). In a Cox proportional regression model for all-cause mortality, SBP <90 mmHg had a hazard ratio (HR) of 4.00 (95% confidence interval [CI] 1.49-10.78, P = 0.006), LVEF had an HR of 0.94 (95% CI 0.91-0.98, P = 0.003, B = 0.06%), and use of angiotensin-converting enzyme or angiotensin receptor and/or β-receptor blockers had an HR of 1.71 (95% CI 0.93-3.16, P = 0.085). However, SBP was not associated with LV function recovery.Conclusion: In our cohort of PPCM patients, one-fifth was hypotensive at presentation. SBP <90 mmHg at presentation was associated with a four-fold higher risk of all-cause mortality during a median follow-up of 18 months.

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  • Balarabe, S.A.Department of Medicine, Muhammad Abdullahi Wase Specialist Hospital, Kano, Nigeria (author)
  • Ishaq, N.A.Department of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria (author)
  • Adamu, U.G.Department of Medicine, Federal Medical Center Bidda, Nigeria (author)
  • Mohammed, I.Y.Department of Chemical Pathology, Bayero University/Aminu Kano Teaching Hospital, Kano, Nigeria (author)
  • Oboirien, I.Department of Medicine, Dalhatu Araf Specialist Hospital, Lafia, Nigeria (author)
  • Umuerri, E.M.Department of Medicine, Delta State University Teaching Hospital, Nigeria (author)
  • Mankwe, A.C.Department of Medicine, Federal Medical Center Yenagoa, Yenagoa, Nigeria (author)
  • Shidali, V.Y.Department of Medicine, Federal Medical Center Keffi, Keffi, Nigeria (author)
  • Njoku, P.Department of Medicine, University of Nigeria Teaching Hospital, Enugu, Nigeria (author)
  • Dodiyi-Manuel, S.Department of Medicine, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria (author)
  • Olunuga, T.Department of Medicine, Federal Medical Center Abeokuta, Abeokuta, Nigeria (author)
  • Josephs, V.Department of Medicine, University of Benin Teaching Hospital, Nigeria (author)
  • Mbakwem, A.C.Department of Medicine, University of Lagos Teaching Hospital, Lagos, Nigeria (author)
  • Okolie, H.Department of Medicine, Federal Teaching Hospital, Gombe, Nigeria (author)
  • Talle, M.A.Department of Medicine, University of Maiduguri Teaching Hospital, Maiduguri, Nigeria (author)
  • Isa, M.S.Department of Medicine, Ahmadu Bello University Teaching Hospital, Zaria, Nigeria (author)
  • Adebayo, R.A.Department of Medicine, Obafemi Awolowo University Teaching Hospital, Nigeria (author)
  • Tukur, J.Department of Medicine, Bayero University, Kano, Nigeria (author)
  • Isezuo, S.A.Department of Medicine, Usman Danfodio University Teaching Hospital, Sokoto, Nigeria (author)
  • Umar, H.Department of Medicine, Usman Danfodio University Teaching Hospital, Sokoto, Nigeria (author)
  • Shehu, M.N.Department of Medicine, General Ahmadi Kurfi Specialist Hospital, Katsina, Nigeria (author)
  • Ogah, O.S.Department of Medicine, University College Hospital, Ibadan; Institute of Advanced Medical Research and Training, University of Ibadan, Nigeria (author)
  • Karaye, Kamilu MusaUmeå universitet,Institutionen för folkhälsa och klinisk medicin,Department of Medicine, Bayero University, Nigeria; Department of Medicine, Aminu Kano Teaching Hospital, Kano, Nigeria; Hatter Institute for Cardiovascular Research in Africa, Capetown, South Africa(Swepub:umu)kamu0022 (author)
  • Department of Medicine, Bayero University; Department of Medicine, Murtala Mohammed Specialist Hospital, Kano, NigeriaDepartment of Medicine, Muhammad Abdullahi Wase Specialist Hospital, Kano, Nigeria (creator_code:org_t)

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  • In:Nigerian Journal of Clinical Practice: Wolters Kluwer25:12, s. 1963-19681119-30772229-7731

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