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Mild-to-moderate ki...
Mild-to-moderate kidney dysfunction and cardiovascular disease : Observational and mendelian randomization analyses
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- Gaziano, Liam (author)
- University of Cambridge,Boston Veteran's Administration (VA) Healthcare
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Sun, Luanluan (author)
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Arnold, Matthew (author)
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Bell, Steven (author)
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Cho, Kelly (author)
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Kaptoge, Stephen K. (author)
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Song, Rebecca J. (author)
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Burgess, Stephen (author)
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Posner, Daniel C. (author)
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Mosconi, Katja (author)
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Robinson-Cohen, Cassianne (author)
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Mason, Amy M. (author)
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Bolton, Thomas R. (author)
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Tao, Ran (author)
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Allara, Elias (author)
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Schubert, Petra (author)
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Chen, Lingyan (author)
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Staley, James R. (author)
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Staplin, Natalie (author)
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Altay, Servet (author)
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Amiano, Pilar (author)
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Arndt, Volker (author)
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- Ärnlöv, Johan, 1970- (author)
- Karolinska Institutet,Högskolan Dalarna,Medicinsk vetenskap
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Barr, Elizabeth L. M. (author)
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Björkelund, Cecilia (author)
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Boer, Jolanda M. A. (author)
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Brenner, Hermann (author)
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Casiglia, Edoardo (author)
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Chiodini, Paolo (author)
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Cooper, Jackie A. (author)
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Coresh, Josef (author)
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Cushman, Mary (author)
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Dankner, Rachel (author)
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Davidson, Karina W. (author)
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de Jongh, Renate T. (author)
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Donfrancesco, Chiara (author)
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- Engström, G. (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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Freisling, Heinz (author)
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de la Cámara, Agustín Gómez (author)
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Gudnason, Vilmundur (author)
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Hankey, Graeme J. (author)
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- Hansson, Per-Olof, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Heath, Alicia K. (author)
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Hoorn, Ewout J. (author)
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Imano, Hironori (author)
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Jassal, Simerjot K. (author)
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Kaaks, Rudolf (author)
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Katzke, Verena (author)
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Kauhanen, Jussi (author)
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Kiechl, Stefan (author)
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Koenig, Wolfgang (author)
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Kronmal, Richard A. (author)
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Kyrø, Cecilie (author)
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Lawlor, Deborah A. (author)
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- Ljungberg, Börje, Professor, 1949- (author)
- Umeå universitet,Urologi och andrologi
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MacDonald, Conor (author)
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Masala, Giovanna (author)
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Meisinger, Christa (author)
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- Melander, O. (author)
- Lund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups
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Moreno Iribas, Conchi (author)
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Ninomiya, Toshiharu (author)
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Nitsch, Dorothea (author)
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Nordestgaard, Børge G. (author)
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Onland-Moret, Charlotte (author)
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Palmieri, Luigi (author)
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Petrova, Dafina (author)
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Garcia, Jose Ramón Quirós (author)
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- Rosengren, Annika, 1951 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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Sacerdote, Carlotta (author)
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Sakurai, Masaru (author)
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Santiuste, Carmen (author)
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Schulze, Matthias B. (author)
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Sieri, Sabina (author)
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- Sundström, Johan, Professor, 1971- (author)
- Uppsala universitet,Klinisk epidemiologi
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Tikhonoff, Valérie (author)
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Tjønneland, Anne (author)
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Tong, Tammy (author)
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Tumino, Rosario (author)
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Tzoulaki, Ioanna (author)
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van der Schouw, Yvonne T. (author)
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Monique Verschuren, W. M. (author)
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Völzke, Henry (author)
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Wallace, Robert B. (author)
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Wannamethee, S. Goya (author)
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Weiderpass, Elisabete (author)
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Willeit, Peter (author)
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Woodward, Mark (author)
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Yamagishi, Kazumasa (author)
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Zamora-Ros, Raul (author)
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Akwo, Elvis A. (author)
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Pyarajan, Saiju (author)
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Gagnon, David R. (author)
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Tsao, Philip S. (author)
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Muralidhar, Sumitra (author)
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Edwards, Todd L. (author)
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Damrauer, Scott M. (author)
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Joseph, Jacob (author)
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Pennells, Lisa (author)
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Wilson, Peter W. F. (author)
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Harrison, Seamus (author)
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Gaziano, Thomas A. (author)
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Inouye, Michael (author)
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Baigent, Colin (author)
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Casas, Juan P. (author)
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Langenberg, Claudia (author)
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Wareham, Nick (author)
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Riboli, Elio (author)
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Gaziano, J. Michael (author)
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Danesh, John (author)
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Hung, Adriana M. (author)
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Butterworth, Adam S. (author)
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Wood, Angela M. (author)
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- Di Angelantonio, Emanuele (author)
- Human Technopole,University of Cambridge
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OnlandMoret, C (author)
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ZamoraRos, R (author)
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et al
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- Wolters Kluwer, 2022
- 2022
- English.
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In: Circulation. - : Wolters Kluwer. - 0009-7322 .- 1524-4539. ; 146:20, s. 1507-1517
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- BACKGROUND: End-stage renal disease is associated with a high risk of cardiovascular events. It is unknown, however, whether mild-to-moderate kidney dysfunction is causally related to coronary heart disease (CHD) and stroke.METHODS: Observational analyses were conducted using individual-level data from 4 population data sources (Emerging Risk Factors Collaboration, EPIC-CVD [European Prospective Investigation into Cancer and Nutrition-Cardiovascular Disease Study], Million Veteran Program, and UK Biobank), comprising 648 135 participants with no history of cardiovascular disease or diabetes at baseline, yielding 42 858 and 15 693 incident CHD and stroke events, respectively, during 6.8 million person-years of follow-up. Using a genetic risk score of 218 variants for estimated glomerular filtration rate (eGFR), we conducted Mendelian randomization analyses involving 413 718 participants (25 917 CHD and 8622 strokes) in EPIC-CVD, Million Veteran Program, and UK Biobank.RESULTS: There were U-shaped observational associations of creatinine-based eGFR with CHD and stroke, with higher risk in participants with eGFR values <60 or >105 mL·min-1·1.73 m-2, compared with those with eGFR between 60 and 105 mL·min-1·1.73 m-2. Mendelian randomization analyses for CHD showed an association among participants with eGFR <60 mL·min-1·1.73 m-2, with a 14% (95% CI, 3%-27%) higher CHD risk per 5 mL·min-1·1.73 m-2 lower genetically predicted eGFR, but not for those with eGFR >105 mL·min-1·1.73 m-2. Results were not materially different after adjustment for factors associated with the eGFR genetic risk score, such as lipoprotein(a), triglycerides, hemoglobin A1c, and blood pressure. Mendelian randomization results for stroke were nonsignificant but broadly similar to those for CHD.CONCLUSIONS: In people without manifest cardiovascular disease or diabetes, mild-to-moderate kidney dysfunction is causally related to risk of CHD, highlighting the potential value of preventive approaches that preserve and modulate kidney function.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Allmänmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- General Practice (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
Keyword
- cardiovascular diseases
- coronary disease
- kidney diseases
- stroke
- cardiovascular diseases
- coronary disease
- kidney diseases
- stroke
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Gaziano, Liam
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Sun, Luanluan
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Arnold, Matthew
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Bell, Steven
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Cho, Kelly
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Kaptoge, Stephen ...
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show more...
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Song, Rebecca J.
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Burgess, Stephen
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Posner, Daniel C ...
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Mosconi, Katja
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Robinson-Cohen, ...
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Mason, Amy M.
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Bolton, Thomas R ...
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Tao, Ran
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Allara, Elias
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Schubert, Petra
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Chen, Lingyan
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Staley, James R.
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Staplin, Natalie
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Altay, Servet
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Amiano, Pilar
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Arndt, Volker
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Ärnlöv, Johan, 1 ...
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Barr, Elizabeth ...
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Björkelund, Ceci ...
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Boer, Jolanda M. ...
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Brenner, Hermann
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Casiglia, Edoard ...
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Chiodini, Paolo
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Cooper, Jackie A ...
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Coresh, Josef
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Cushman, Mary
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Dankner, Rachel
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Davidson, Karina ...
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de Jongh, Renate ...
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Donfrancesco, Ch ...
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Engström, G.
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Freisling, Heinz
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de la Cámara, Ag ...
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Gudnason, Vilmun ...
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Hankey, Graeme J ...
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Hansson, Per-Olo ...
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Heath, Alicia K.
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Hoorn, Ewout J.
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Imano, Hironori
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Jassal, Simerjot ...
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Kaaks, Rudolf
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Katzke, Verena
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Kauhanen, Jussi
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Kiechl, Stefan
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Koenig, Wolfgang
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Kronmal, Richard ...
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Kyrø, Cecilie
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Lawlor, Deborah ...
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Ljungberg, Börje ...
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MacDonald, Conor
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Masala, Giovanna
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Meisinger, Chris ...
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Melander, O.
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Moreno Iribas, C ...
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Ninomiya, Toshih ...
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Nitsch, Dorothea
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Nordestgaard, Bø ...
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Onland-Moret, Ch ...
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Palmieri, Luigi
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Petrova, Dafina
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Garcia, Jose Ram ...
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Rosengren, Annik ...
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Sacerdote, Carlo ...
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Sakurai, Masaru
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Santiuste, Carme ...
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Schulze, Matthia ...
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Sieri, Sabina
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Sundström, Johan ...
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Tikhonoff, Valér ...
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Tjønneland, Anne
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Tong, Tammy
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Tumino, Rosario
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Tzoulaki, Ioanna
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van der Schouw, ...
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Monique Verschur ...
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Völzke, Henry
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Wallace, Robert ...
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Wannamethee, S. ...
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Weiderpass, Elis ...
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Willeit, Peter
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Woodward, Mark
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Yamagishi, Kazum ...
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Zamora-Ros, Raul
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Akwo, Elvis A.
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Pyarajan, Saiju
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Gagnon, David R.
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Tsao, Philip S.
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Muralidhar, Sumi ...
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Edwards, Todd L.
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Damrauer, Scott ...
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Joseph, Jacob
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Pennells, Lisa
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Wilson, Peter W. ...
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Harrison, Seamus
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Gaziano, Thomas ...
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Inouye, Michael
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Baigent, Colin
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Casas, Juan P.
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Langenberg, Clau ...
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Wareham, Nick
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Riboli, Elio
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Gaziano, J. Mich ...
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Danesh, John
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Hung, Adriana M.
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Butterworth, Ada ...
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Wood, Angela M.
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Di Angelantonio, ...
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OnlandMoret, C
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ZamoraRos, R
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and General Practice
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
- Articles in the publication
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Circulation
- By the university
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Umeå University
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Högskolan Dalarna
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Uppsala University
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Karolinska Institutet
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Lund University
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University of Gothenburg