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VALZ-Pilot :
VALZ-Pilot : High-dose valacyclovir treatment in patients with early-stage Alzheimer's disease
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- Weidung, Bodil (author)
- Uppsala universitet,Geriatrik
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- Hemmingsson, Eva-Stina (author)
- Umeå universitet,Geriatrik,Umeå Univ, Dept Community Med & Rehabil, Geriatr Med, Umeå, Sweden.
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- Olsson, Jan (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Umeå Univ, Dept Clin Microbiol, Umeå, Sweden.
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- Sundström, Torbjörn (author)
- Umeå universitet,Diagnostisk radiologi,Umeå Univ, Diagnost Radiol, Dept Radiat Sci, Umeå, Sweden.
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- Blennow, Kaj, 1958 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Zetterberg, Henrik, 1973 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry
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- Ingelsson, Martin (author)
- Uppsala universitet,Geriatrik,Univ Hlth Network, Krembil Brain Inst, Toronto, ON, Canada.;Univ Toronto, Dept Med, Toronto, ON, Canada.;Univ Toronto, Tanz Ctr Res Neurodegenerat Dis, Toronto, ON, Canada.
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- Elgh, Fredrik, 1957- (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Umeå Univ, Dept Clin Microbiol, Umeå, Sweden.
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- Lövheim, Hugo, 1981- (author)
- Umeå universitet,Geriatrik,Wallenberg Centre for Molecular Medicin, Umeå, Sweden,Umeå Univ, Dept Community Med & Rehabil, Geriatr Med, Umeå, Sweden.;Wallenberg Ctr Mol Med, Umeå, Sweden.
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(creator_code:org_t)
- 2022-03-14
- 2022
- English.
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In: Alzheimer’s & Dementia. - : John Wiley & Sons. - 2352-8737. ; 8:1
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Abstract
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- Introduction: Herpes simplex virus (HSV) may be involved in Alzheimer's disease (AD) pathophysiology. The antiviral valacyclovir inhibits HSV replication.Methods: This phase-II pilot trial involved valacyclovir administration (thrice daily, 500 mg week 1, 1000 mg weeks 2–4) to persons aged ≥ 65 years with early-stage AD, anti-HSV immunoglobulin G, and apolipoprotein E ε4. Intervention safety, tolerability, feasibility, and effects on Mini-Mental State Examination (MMSE) scores and cerebrospinal fluid (CSF) biomarkers were evaluated.Results: Thirty-two of 33 subjects completed the trial on full dosage. Eighteen percent experienced likely intervention-related mild, temporary adverse events. CSF acyclovir concentrations were mean 5.29 ± 2.31 μmol/L. CSF total tau and neurofilament light concentrations were unchanged; MMSE score and CSF soluble triggering receptor expressed on myeloid cells 2 concentrations increased (P = .02 and .03).Discussion: Four weeks of high-dose valacyclovir treatment was safe, tolerable, and feasible in early-stage AD. Our findings may guide future trial design.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Alzheimer's disease
- apolipoprotein E ε4
- feasibility study
- herpes simplex
- pilot project
- valacyclovir
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Weidung, Bodil
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Hemmingsson, Eva ...
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Olsson, Jan
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Sundström, Torbj ...
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Blennow, Kaj, 19 ...
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Zetterberg, Henr ...
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Ingelsson, Marti ...
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Elgh, Fredrik, 1 ...
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Lövheim, Hugo, 1 ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Neurosciences
- Articles in the publication
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Alzheimer’s & De ...
- By the university
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Umeå University
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Uppsala University
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University of Gothenburg