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Augmented enterocyt...
Augmented enterocyte damage during Candida albicans and Proteus mirabilis coinfection
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- Niemiec, Maria Joanna (author)
- Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute, Jena, Germany; Center for Sepsis Control and Care, Jena, Germany
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- Kapitan, Mario (author)
- Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute, Jena, Germany; Center for Sepsis Control and Care, Jena, Germany
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- Himmel, Maximilian (author)
- Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute, Jena, Germany
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- Döll, Kristina (author)
- Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute, Jena, Germany
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- Krüger, Thomas (author)
- Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute, Jena, Germany
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- Köllner, Tobias G. (author)
- Department of Biochemistry, Max Planck Institute for Chemical Ecology, Jena, Germany
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- Auge, Isabel (author)
- Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute, Jena, Germany
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- Kage, Franziska (author)
- Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute, Jena, Germany
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- Alteri, Christopher J. (author)
- Department of Natural Sciences, University of Michigan-Dearborn, MI, Dearborn, United States
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- Mobley, Harry L.T. (author)
- Department of Microbiology and Immunology, University of Michigan Medical School, MI, Ann Arbor, United States
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- Monsen, Tor J. (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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- Linde, Susanne (author)
- Center for Electron Microscopy, University Hospital, Jena, Germany
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- Nietzsche, Sandor (author)
- Center for Electron Microscopy, University Hospital, Jena, Germany
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- Kniemeyer, Olaf (author)
- Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute, Jena, Germany
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- Brakhage, Axel A. (author)
- Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute, Jena, Germany; Institute of Microbiology, Friedrich Schiller University, Jena, Germany
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- Jacobsen, Ilse D. (author)
- Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute, Jena, Germany; Center for Sepsis Control and Care, Jena, Germany; Institute of Microbiology, Friedrich Schiller University, Jena, Germany
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(creator_code:org_t)
- 2022-05-16
- 2022
- English.
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In: Frontiers in Cellular and Infection Microbiology. - : Frontiers Media S.A.. - 2235-2988. ; 12
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https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
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Abstract
Subject headings
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- The human gut acts as the main reservoir of microbes and a relevant source of life-threatening infections, especially in immunocompromised patients. There, the opportunistic fungal pathogen Candida albicans adapts to the host environment and additionally interacts with residing bacteria. We investigated fungal-bacterial interactions by coinfecting enterocytes with the yeast Candida albicans and the Gram-negative bacterium Proteus mirabilis resulting in enhanced host cell damage. This synergistic effect was conserved across different P. mirabilis isolates and occurred also with non-albicans Candida species and C. albicans mutants defective in filamentation or candidalysin production. Using bacterial deletion mutants, we identified the P. mirabilis hemolysin HpmA to be the key effector for host cell destruction. Spatially separated coinfections demonstrated that synergism between Candida and Proteus is induced by contact, but also by soluble factors. Specifically, we identified Candida-mediated glucose consumption and farnesol production as potential triggers for Proteus virulence. In summary, our study demonstrates that coinfection of enterocytes with C. albicans and P. mirabilis can result in increased host cell damage which is mediated by bacterial virulence factors as a result of fungal niche modification via nutrient consumption and production of soluble factors. This supports the notion that certain fungal-bacterial combinations have the potential to result in enhanced virulence in niches such as the gut and might therefore promote translocation and dissemination.
Subject headings
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- Candida albicans
- coinfection
- cross-kingdom interaction
- enterocytes
- Proteus mirabilis
- synergism
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Niemiec, Maria J ...
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Kapitan, Mario
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Himmel, Maximili ...
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Döll, Kristina
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Krüger, Thomas
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Köllner, Tobias ...
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show more...
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Auge, Isabel
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Kage, Franziska
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Alteri, Christop ...
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Mobley, Harry L. ...
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Monsen, Tor J.
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Linde, Susanne
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Nietzsche, Sando ...
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Kniemeyer, Olaf
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Brakhage, Axel A ...
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Jacobsen, Ilse D ...
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Microbiology
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
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Frontiers in Cel ...
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Umeå University