onr:"swepub:oai:DiVA.org:umu-204791"
Search: onr:"swepub:oai:DiVA.org:umu-204791" > Immune-activated B ...
- 1 of 1
- Previous record
- Next record
- To hitlist
Immune-activated B cells are dominant in prostate cancer
-
- Saudi, Aws (author)
- Linköpings universitet,Institutionen för biomedicinska och kliniska vetenskaper,Medicinska fakulteten,Region Östergötland, Urologiska kliniken i Östergötland
-
- Banday, Viqar Showkat (author)
- Umeå universitet,Urologi och andrologi,Immunologi/immunkemi,Umea Univ, Sweden; Umea Univ, Sweden
-
- Zirakzadeh, A. Ali (author)
- Immuneed AB, Sweden
- show more...
- show less...
- (creator_code:org_t)
- 2023-02-01
- 2023
- English.
- In: Cancers. - : MDPI. - 2072-6694. ; 15:3
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- B cells are multifaceted immune cells responding robustly during immune surveillance against tumor antigens by presentation to T cells and switched immunoglobulin production. However, B cells are unstudied in prostate cancer (PCa). We used flow cytometry to analyze B-cell subpopulations in peripheral blood and lymph nodes from intermediate-high risk PCa patients. B-cell subpopulations were related to clinicopathological factors. B-cell-receptor single-cell sequencing and VDJ analysis identified clonal B-cell expansion in blood and lymph nodes. Pathological staging was pT2 in 16%, pT3a in 48%, and pT3b in 36%. Lymph node metastases occurred in 5/25 patients (20%). Compared to healthy donors, the peripheral blood CD19+ B-cell compartment was significantly decreased in PCa patients and dominated by naïve B cells. The nodal B-cell compartment had significantly increased fractions of CD19+ B cells and switched memory B cells. Plasmablasts were observed in tumor-draining sentinel lymph nodes (SNs). VDJ analysis revealed clonal expansion in lymph nodes. Thus, activated B cells are increased in SNs from PCa patients. The increased fraction of switched memory cells and plasmablasts together with the presence of clonally expanded B cells indicate tumor-specific T-cell-dependent responses from B cells, supporting an important role for B cells in the protection against tumors.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- B cells
- T cells
- prostatic neoplasms
- sentinel lymph node biopsy
Publication and Content Type
- ref (subject category)
- art (subject category)
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Saudi, Aws
- Banday, Viqar Sh ...
- Zirakzadeh, A. A ...
- Selinger, Martin
- Forsberg, Jon
- Holmbom, Martin
- show more...
- Henriksson, Joha ...
- Waldén, Mauritz
- Alamdari, Farhoo ...
- Aljabery, Firas
- Winqvist, Ola
- Sherif, Amir
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Urology and Neph ...
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Cell and Molecul ...
- Articles in the publication
- Cancers
- By the university
- Umeå University
- Linköping University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
