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Cellular states are coupled to genomic and viral heterogeneity in HPV-related oropharyngeal carcinoma

Puram, Sidharth V. (author)
Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St. Louis, United States; Department of Genetics, Washington University School of Medicine, MO, St. Louis, United States; Siteman Cancer Center, Washington University in St. Louis, MO, St. Louis, United States
Mints, Michael (author)
Karolinska Institutet,Umeå universitet,Urologi och andrologi,Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel; Department of Oncology–Pathology, Karolinska Institute, Stockholm, Sweden
Pal, Ananya (author)
Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St. Louis, United States
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Qi, Zongtai (author)
Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St. Louis, United States
Reeb, Ashley (author)
Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St. Louis, United States
Gelev, Kyla (author)
Department of Internal Medicine, Washington University School of Medicine, MO, St. Louis, United States
Barrett, Thomas F. (author)
Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St. Louis, United States
Gerndt, Sophie (author)
Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St. Louis, United States
Liu, Ping (author)
Department of Internal Medicine, Washington University School of Medicine, MO, St. Louis, United States; Department of Radiation Oncology, Washington University School of Medicine, MO, St. Louis, United States
Parikh, Anuraag S. (author)
Department of Otolaryngology–Head and Neck Surgery, Columbia University Irving Medical Center, NY, New York, United States
Ramadan, Salma (author)
Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St. Louis, United States
Law, Travis (author)
Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St. Louis, United States
Mroz, Edmund A. (author)
Department of Otolaryngology–Head and Neck Surgery, Ohio State University, OH, Columbus, United States
Rocco, James W. (author)
Department of Otolaryngology–Head and Neck Surgery, Ohio State University, OH, Columbus, United States
Adkins, Doug (author)
Siteman Cancer Center, Washington University in St. Louis, MO, St. Louis, United States; Department of Medicine, Washington University School of Medicine, MO, St. Louis, United States
Thorstad, Wade L. (author)
Siteman Cancer Center, Washington University in St. Louis, MO, St. Louis, United States; Department of Radiation Oncology, Washington University School of Medicine, MO, St. Louis, United States
Gay, Hiram A. (author)
Siteman Cancer Center, Washington University in St. Louis, MO, St. Louis, United States; Department of Radiation Oncology, Washington University School of Medicine, MO, St. Louis, United States
Ding, Li (author)
Department of Medicine, Washington University School of Medicine, MO, St. Louis, United States; McDonnell Genome Institute, Washington University in St. Louis, MO, St. Louis, United States
Paniello, Randal C. (author)
Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St. Louis, United States; Siteman Cancer Center, Washington University in St. Louis, MO, St. Louis, United States
Pipkorn, Patrik (author)
Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St. Louis, United States; Siteman Cancer Center, Washington University in St. Louis, MO, St. Louis, United States
Jackson, Ryan S. (author)
Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St. Louis, United States; Siteman Cancer Center, Washington University in St. Louis, MO, St. Louis, United States
Wang, Xiaowei (author)
Department of Internal Medicine, Washington University School of Medicine, MO, St. Louis, United States; Department of Pharmacology and Regenerative Medicine, University of Illinois at Chicago, IL, Chicago, United States
Mazul, Angela (author)
Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St. Louis, United States
Chernock, Rebecca (author)
Department of Pathology and Immunology, Washington University School of Medicine, MO, St. Louis, United States
Zevallos, Jose P. (author)
Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St. Louis, United States; Siteman Cancer Center, Washington University in St. Louis, MO, St. Louis, United States
Silva-Fisher, Jessica (author)
Siteman Cancer Center, Washington University in St. Louis, MO, St. Louis, United States; Department of Internal Medicine, Washington University School of Medicine, MO, St. Louis, United States
Tirosh, Itay (author)
Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel
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Department of Otolaryngology—Head and Neck Surgery, Washington University School of Medicine, MO, St Louis, United States; Department of Genetics, Washington University School of Medicine, MO, St. Louis, United States; Siteman Cancer Center, Washington University in St. Louis, MO, St. Louis, United States Urologi och andrologi (creator_code:org_t)
Springer Nature, 2023
2023
English.
In: Nature Genetics. - : Springer Nature. - 1061-4036 .- 1546-1718. ; 55:4, s. 640-650
Related links:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Head and neck squamous cell carcinoma (HNSCC) includes a subset of cancers driven by human papillomavirus (HPV). Here we use single-cell RNA-seq to profile both HPV-positive and HPV-negative oropharyngeal tumors, uncovering a high level of cellular diversity within and between tumors. First, we detect diverse chromosomal aberrations within individual tumors, suggesting genomic instability and enabling the identification of malignant cells even at pathologically negative margins. Second, we uncover diversity with respect to HNSCC subtypes and other cellular states such as the cell cycle, senescence and epithelial-mesenchymal transitions. Third, we find heterogeneity in viral gene expression within HPV-positive tumors. HPV expression is lost or repressed in a subset of cells, which are associated with a decrease in HPV-associated cell cycle phenotypes, decreased response to treatment, increased invasion and poor prognosis. These findings suggest that HPV expression diversity must be considered during diagnosis and treatment of HPV-positive tumors, with important prognostic ramifications.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)

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ref (subject category)
art (subject category)

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