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At-home sampling to...
At-home sampling to meet geographical challenges for serological assessment of SARS-CoV-2 exposure in a rural region of northern Sweden, March to May 2021 : a retrospective cohort study
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- Wigren, Julia (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Xerum AB, Umeå, Sweden
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- Vikström, Linnea (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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- Rosendal, Ebba (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Molekylär Infektionsmedicin, Sverige (MIMS)
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- Gröning, Remigius (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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- Gwon, Yong-Dae (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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- Nilsson, Emma (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Molekylär Infektionsmedicin, Sverige (MIMS)
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- Sharma, Atin (author)
- Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten)
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- Espaillat, Akbar, master, 1988- (author)
- Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten)
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- Hanke, Leo (author)
- Karolinska Institutet
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- McInerney, Gerald (author)
- Karolinska Institutet
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- Puhar, Andrea, 1978- (author)
- Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten)
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- Cava, Felipe (author)
- Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten)
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- Karlsson Hedestam, Gunilla B. (author)
- Karolinska Institutet
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- Thunberg, Therese, 1977- (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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- Monsen, Tor (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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- Elgh, Fredrik, 1957- (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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- Evander, Magnus (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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- Johansson, Anders F., 1966- (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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- Överby, Anna K. (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Molekylär Infektionsmedicin, Sverige (MIMS)
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- Ahlm, Clas, 1956- (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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- Normark, Johan (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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- Forsell, Mattias N. E. (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi
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(creator_code:org_t)
- European Centre for Disease Control and Prevention (ECDC), 2023
- 2023
- English.
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In: Eurosurveillance. - : European Centre for Disease Control and Prevention (ECDC). - 1025-496X .- 1560-7917. ; 28:13
- Related links:
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https://doi.org/10.2...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.2...
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http://kipublication...
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Abstract
Subject headings
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- Background: The current SARS-CoV-2 pandemic has highlighted a need for easy and safe blood sampling in combination with accurate serological methodology. Venipuncture for testing is usually performed by trained staff at healthcare centres. Long travel distances to healthcare centres in rural regions may introduce a bias of testing towards relatively large communities with closer access. Rural regions are therefore often not represented in population-based data.Aim: The aim of this retrospective cohort study was to develop and implement a strategy for at-home testing in a rural region of Sweden during spring 2021, and to evaluate its role to provide equal health care for its inhabitants.Methods: We developed a sensitive method to measure antibodies to the S-protein of SARS-CoV-2 and optimised this assay for clinical use together with a strategy of at-home capillary blood sampling.Results: We demonstrated that our ELISA gave comparable results after analysis of capillary blood or serum from SARS-CoV-2-experienced individuals. We demonstrated stability of the assay under conditions that reflected temperature and humidity during winter or summer. By assessment of capillary blood samples from 4,122 individuals, we could show both feasibility of the strategy and that implementation shifted the geographical spread of testing in favour of rural areas.Conclusion: Implementation of at-home sampling enabled citizens living in remote rural areas access to centralised and sensitive laboratory antibody tests. The strategy for testing used here could therefore enable disease control authorities to get rapid access to information concerning immunity to infectious diseases, even across vast geographical distance.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Keyword
- coronavirus disease (COVID-19)
- laboratory
- surveillance
- Sweden
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Wigren, Julia
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Vikström, Linnea
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Rosendal, Ebba
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Gröning, Remigiu ...
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Gwon, Yong-Dae
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Nilsson, Emma
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show more...
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Sharma, Atin
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Espaillat, Akbar ...
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Hanke, Leo
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McInerney, Geral ...
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Puhar, Andrea, 1 ...
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Cava, Felipe
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Karlsson Hedesta ...
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Thunberg, Theres ...
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Monsen, Tor
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Elgh, Fredrik, 1 ...
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Evander, Magnus
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Johansson, Ander ...
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Överby, Anna K.
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Ahlm, Clas, 1956 ...
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Normark, Johan
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Forsell, Mattias ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Microbiology in ...
- Articles in the publication
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Eurosurveillance
- By the university
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Umeå University
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Karolinska Institutet