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- Imamovic, MarcusUmeå universitet,Institutionen för folkhälsa och klinisk medicin (author)
Confounding effects of liquorice, hydrocortisone, and blood contamination on salivary cortisol but not cortisone
- Article/chapterEnglish2023
Publisher, publication year, extent ...
- Bioscientifica,2023
- electronicrdacarrier
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- LIBRIS-ID:oai:DiVA.org:umu-208130
- https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-208130URI
- https://doi.org/10.1530/ec-22-0324DOI
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- Language:English
- Summary in:English
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- Objective: To determine the effects of liquorice consumption, topical hydrocortisone, and blood contamination on salivary cortisol and cortisone concentrations.Design and methods: Thirty healthy volunteers were randomized to a low, medium, or high dose of liquorice. Late-night saliva samples were collected using a Salivette® collection device at baseline, during 1 week of daily liquorice consumption, and during 4 weeks' washout. Saliva sampling was also performed before and after the application of topical hydrocortisone on the skin. Furthermore, in a subgroup (n = 16), saliva and venous blood were collected from each individual and mixed to achieve graded blood contamination in saliva. Salivary cortisol and cortisone were analyzed with liquid chromatography-tandem mass spectrometry.Results: Significant increases in salivary cortisol concentrations were observed during medium- (+49%) and high-dose (+97%) liquorice intake, which returned to baseline 4 days after liquorice withdrawal. Topical hydrocortisone on fingers holding the collection swab increased salivary cortisol concentrations >1000-fold with concomitant pronounced elevation of the cortisol:cortisone ratio. Salivary cortisol increased significantly after contamination with blood ≥0.5%. Visual examination could safely detect these samples. Salivary cortisone concentrations were unaffected by liquorice consumption and blood contamination, and only marginally affected by topical hydrocortisone.Conclusion: Liquorice, topical hydrocortisone, and blood contamination may all cause elevated salivary cortisol concentrations. Improved sampling instructions and visual examination of the sample may minimize these risks. Salivary cortisone is essentially unaffected by the different preanalytical confounders and may be used as a first-line screening test for Cushing's syndrome.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Klinisk medicin Endokrinologi och diabetes hsv//swe
- MEDICAL AND HEALTH SCIENCES Clinical Medicine Endocrinology and Diabetes hsv//eng
- Cushing’s syndrome
- salivary cortisol
- salivary cortisone
- liquorice
- sample contamination
Added entries (persons, corporate bodies, meetings, titles ...)
- Bäcklund, NilsUmeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)niba0024 (author)
- Lundstedt, StaffanUmeå universitet,Klinisk kemi(Swepub:umu)stlu0002 (author)
- Brattsand, GöranUmeå universitet,Klinisk kemi(Swepub:umu)gobr0001 (author)
- Aardal, ElisabethDepartment of Clinical Chemistry and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden (author)
- Olsson, TommyUmeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)tool0003 (author)
- Dahlqvist, PerUmeå universitet,Institutionen för folkhälsa och klinisk medicin(Swepub:umu)perdat96 (author)
- Umeå universitetInstitutionen för folkhälsa och klinisk medicin (creator_code:org_t)
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- In:Endocrine Connections: Bioscientifica12:12049-3614
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