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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00012801naa a2200901 4500
001oai:DiVA.org:umu-212103
003SwePub
008230717s2023 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2121032 URI
0247 a https://doi.org/10.1016/j.jtho.2023.05.0012 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Cheng, Chaou Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Texas, Houston, United States4 aut
2451 0a Mosaic chromosomal alterations are associated with increased lung cancer risk :b insight from the INTEGRAL-ILCCO cohort analysis
264 1b Elsevier,c 2023
338 a print2 rdacarrier
520 a Introduction: Mosaic chromosomal alterations (mCAs) detected in white blood cells represent a type of clonal hematopoiesis (CH) that is understudied compared with CH-related somatic mutations. A few recent studies indicated their potential link with nonhematological cancers, especially lung cancer. Methods: In this study, we investigated the association between mCAs and lung cancer using the high-density genotyping data from the OncoArray study of INTEGRAL-ILCCO, the largest single genetic study of lung cancer with 18,221 lung cancer cases and 14,825 cancer-free controls. Results: We identified a comprehensive list of autosomal mCAs, ChrX mCAs, and mosaic ChrY (mChrY) losses from these samples. Autosomal mCAs were detected in 4.3% of subjects, in addition to ChrX mCAs in 3.6% of females and mChrY losses in 9.6% of males. Multivariable logistic regression analysis indicated that the presence of autosomal mCAs in white blood cells was associated with an increased lung cancer risk after adjusting for key confounding factors, including age, sex, smoking status, and race. This association was mainly driven by a specific type of mCAs: copy-neutral loss of heterozygosity on autosomal chromosomes. The association between autosome copy-neutral loss of heterozygosity and increased risk of lung cancer was further confirmed in two major histologic subtypes, lung adenocarcinoma and squamous cell carcinoma. In addition, we observed a significant increase of ChrX mCAs and mChrY losses in smokers compared with nonsmokers and racial differences in certain types of mCA events. Conclusions: Our study established a link between mCAs in white blood cells and increased risk of lung cancer.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng
653 a Clonal hematopoiesis
653 a Loss of heterozygosity
653 a Lung cancer risk
653 a Mosaic chromosomal alterations
7001 a Hong, Weiu Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States4 aut
7001 a Li, Yafangu Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Texas, Houston, United States4 aut
7001 a Xiao, Xiangjunu Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States4 aut
7001 a McKay, Jamesu Section of Genetics, International Agency for Research on Cancer, WHO, Lyon, France4 aut
7001 a Han, Younghunu Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States4 aut
7001 a Byun, Jinyoungu Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States4 aut
7001 a Peng, Bou Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States4 aut
7001 a Albanes, Demetriosu Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Maryland, Bethesda, United States4 aut
7001 a Lam, Stephenu Department of Integrative Oncology, University of British Columbia, BC, Vancouver, Canada4 aut
7001 a Tardon, Adoninau Public Health Department, University of Oviedo, ISPA and CIBERESP, Asturias, Spain4 aut
7001 a Chen, Chuu Program in Epidemiology, Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States4 aut
7001 a Bojesen, Stig E.u Department of Clinical Biochemistry, Copenhagen University Hospital, Copenhagen, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark4 aut
7001 a Landi, Maria T.u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Maryland, Bethesda, United States4 aut
7001 a Johansson, Mattiasu Section of Genetics, International Agency for Research on Cancer, WHO, Lyon, France4 aut
7001 a Risch, Angelau Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany; Translational Lung Research Center Heidelberg (TLRC-H), Heidelberg, Germany; University of Salzburg and Cancer Cluster Salzburg, Salzburg, Austria4 aut
7001 a Bickeböller, Heikeu Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Göttingen, Germany4 aut
7001 a Wichmann, H-Erichu Institute of Medical Statistics and Epidemiology, Technical University Munich, Munich, Germany4 aut
7001 a Christiani, David C.u Department of Environmental Health, Harvard T.H. Chan School of Public Health, Massachusetts, Boston, United States; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Massachusetts, Boston, United States4 aut
7001 a Rennert, Gadu Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Haifa, Israel4 aut
7001 a Arnold, Susanneu University of Kentucky, Markey Cancer Center, Kentucky, Lexington, United States4 aut
7001 a Goodman, Garyu Swedish Cancer Institute, WA, Seattle, United States4 aut
7001 a Field, John K.u Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom4 aut
7001 a Davies, Michael P.A.u Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, United Kingdom4 aut
7001 a Shete, Sanjay S.u Department of Biostatistics, The University of Texas M. D. Anderson Cancer Center, Texas, Houston, United States; Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Texas, Houston, United States4 aut
7001 a Le Marchand, Loicu Epidemiology Program, University of Hawaii Cancer Center, HI, Honolulu, United States4 aut
7001 a Liu, Geoffreyu University Health Network- The Princess Margaret Cancer Centre, California, Toronto, United States4 aut
7001 a Hung, Rayjean J.u Luenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Canada; Division of Epidemiology, Dalla Lana School of Public Health, University of Toronto, Toronto, Canada4 aut
7001 a Andrew, Angeline S.u Department of Epidemiology, Dartmouth College, New Hampshire, Hanover, United States; Department of Community and Family Medicine, Dartmouth College, New Hampshire, Hanover, United States4 aut
7001 a Kiemeney, Lambertus A.u Radboud University Medical Center, Nijmegen, Netherlands4 aut
7001 a Zhu, Mengu Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China4 aut
7001 a Shen, Hongbingu Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, School of Public Health, Nanjing Medical University, Nanjing, China4 aut
7001 a Zienolddiny, Shanu National Institute of Occupational Health, Oslo, Norway4 aut
7001 a Grankvist, Kjellu Umeå universitet,Institutionen för medicinsk biovetenskap4 aut0 (Swepub:umu)kjgr0002
7001 a Johansson, Mikaelu Umeå universitet,Institutionen för strålningsvetenskaper4 aut0 (Swepub:umu)mijo0025
7001 a Cox, Angelau Academic Unit of Clinical Oncology University of Sheffield, Weston Park Hospital, Whitham Road, Sheffield, United Kingdom4 aut
7001 a Hong, Yun-Chulu Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, South Korea4 aut
7001 a Yuan, Jian-Minu University of Pittsburgh Medical Center (UPMC) Hillman Cancer Center, PA, Pittsburgh, United States4 aut
7001 a Lazarus, Philipu Department of Pharmaceutical Sciences, College of Pharmacy and Pharmaceutical Sciences, Washington State University, WA, Spokane, United States4 aut
7001 a Schabath, Matthew B.u Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center and Research Institute, Florida, Tampa, United States4 aut
7001 a Aldrich, Melinda C.u Department of Medicine, Vanderbilt University Medical Center, TN, Nashville, United States4 aut
7001 a Brennan, Paulu Section of Genetics, International Agency for Research on Cancer, WHO, Lyon, France4 aut
7001 a Li, Yongu Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Texas, Houston, United States4 aut
7001 a Gorlova, Olgau Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Texas, Houston, United States4 aut
7001 a Gorlov, Ivanu Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Texas, Houston, United States4 aut
7001 a Amos, Christopher I.u Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Texas, Houston, United States4 aut
7102 a Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States; Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Texas, Houston, United States; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Texas, Houston, United Statesb Institute for Clinical and Translational Research, Baylor College of Medicine, Texas, Houston, United States4 org
7730 t Journal of Thoracic Oncologyd : Elsevierg 18:8, s. 1003-1016q 18:8<1003-1016x 1556-0864x 1556-1380
8564 u https://doi.org/10.1016/j.jtho.2023.05.001y Fulltext
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-212103
8564 8u https://doi.org/10.1016/j.jtho.2023.05.001

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