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Maternal nutrition ...
Maternal nutrition and epigenetics in early life
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- Hivert, Marie-France (author)
- Department of Population Medicine, Harvard Pilgrim Health Care Institute, Boston, MA, United States; Massachusetts General Hospital, Boston, MA, United States; Department of Medicine, Université de Sherbrooke, Sherbrooke, QC, Canada; Department of Population Medicine, Harvard Pilgrim Health Care Institute, 133 Brookline Avenue, 6th Floor, Boston, MA, 02215, United States
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- Bouchard, Luigi (author)
- Department of Biochemistry, Université de Sherbrooke, Sherbrooke, QC, Canada; ECOGENE-21 Laboratory and Lipid Clinic, Chicoutimi Hospital, Saguenay, QC, United States
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- Franks, Paul W. (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Lund University, Malmö, Sweden; Harvard School of Public Health, Boston, MA, United States
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(creator_code:org_t)
- 2013-08-13
- 2013
- English.
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In: Current Nutrition Reports. - : Springer Science and Business Media LLC. - 2161-3311. ; 2:4, s. 216-224
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Abstract
Subject headings
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- There are increasing evidences that prenatal events influencing in utero milieu and fetal development are associated with risk of developing chronic adult conditions, such as obesity, diabetes, and cardiovascular diseases. Epigenetics is one of the potential molecular mechanisms explaining this phenomenon, often called "fetal metabolic programming." Epigenetics is defined as heritable regulation of DNA transcription that is independent of the DNA sequence and include DNA methylation. In this article, we review recent human studies that investigated associations between epigenetic marks in the offspring and maternal nutritional status, from extreme caloric restriction and nutrients deficiency during pregnancy to maternal obesity and gestational diabetes. Despite human studies being scarce, we are confident that this emerging field will increase our understanding of the biological mechanisms involved in developmental origins of health and adult diseases and inform interventions aimed at primordial prevention of chronic metabolic diseases in future generations.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- B12
- Birth weight
- Caloric restriction
- Choline
- Developmental origins of adult diseases
- DNA methylation
- Epigenetics
- Famine
- Fetal programming
- Folates
- Gestational diabetes mellitus
- Gestational weight gain
- In utero development
- Macronutrient
- Maternal hyperglycemia
- Maternal nutrition
- Metabolic diseases
- Micronutrient deficiency
- obesity
- Under-nutrition
Publication and Content Type
- ref (subject category)
- for (subject category)
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