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Regulators of male ...
Regulators of male and female sexual development are critical for the transmission of a malaria parasite
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- Russell, Andrew J.C. (author)
- Wellcome Sanger Institute, Hinxton, United Kingdom
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- Sanderson, Theo (author)
- Wellcome Sanger Institute, Hinxton, United Kingdom; Francis Crick Institute, 1 Midland Road, London, United Kingdom
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- Bushell, Ellen (author)
- Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten),Wellcome Sanger Institute, Hinxton, United Kingdom
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- Talman, Arthur M. (author)
- Wellcome Sanger Institute, Hinxton, United Kingdom; MIVEGEC, University of Montpellier, IRD, CNRS, Montpellier, France
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- Anar, Burcu (author)
- Wellcome Sanger Institute, Hinxton, United Kingdom
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- Girling, Gareth (author)
- Wellcome Sanger Institute, Hinxton, United Kingdom
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- Hunziker, Mirjam (author)
- Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)
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- Kent, Robyn S. (author)
- Department of Microbiology and Molecular Genetics, University of Vermont Larner College of Medicine, VT, Burlington, United States
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- Martin, Julie S. (author)
- Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity, and Inflammation, University of Glasgow, Glasgow, United Kingdom
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- Metcalf, Tom (author)
- Wellcome Sanger Institute, Hinxton, United Kingdom
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- Montandon, Ruddy (author)
- Wellcome Sanger Institute, Hinxton, United Kingdom
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- Pandey, Vikash (author)
- Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)
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- Pardo, Mercedes (author)
- The Institute of Cancer Research, London, United Kingdom
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- Roberts, A. Brett (author)
- Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity, and Inflammation, University of Glasgow, Glasgow, United Kingdom
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- Sayers, Claire (author)
- Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)
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- Schwach, Frank (author)
- Wellcome Sanger Institute, Hinxton, United Kingdom
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- Choudhary, Jyoti S. (author)
- The Institute of Cancer Research, London, United Kingdom
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- Rayner, Julian C. (author)
- Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
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- Voet, Thierry (author)
- Department of Human Genetics, University of Leuven, KU Leuven, Leuven, Belgium; KU Leuven Institute for Single Cell Omics, LISCO, KU Leuven, Leuven, Belgium
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- Modrzynska, Katarzyna K. (author)
- Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity, and Inflammation, University of Glasgow, Glasgow, United Kingdom
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- Waters, Andrew P. (author)
- Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity, and Inflammation, University of Glasgow, Glasgow, United Kingdom
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- Lawniczak, Mara K.N. (author)
- Wellcome Sanger Institute, Hinxton, United Kingdom
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- Billker, Oliver (author)
- Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)
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(creator_code:org_t)
- Cell Press, 2023
- 2023
- English.
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In: Cell Host and Microbe. - : Cell Press. - 1931-3128 .- 1934-6069. ; 31:2, s. 305-319.e10
- Related links:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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Abstract
Subject headings
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- Malaria transmission to mosquitoes requires a developmental switch in asexually dividing blood-stage parasites to sexual reproduction. In Plasmodium berghei, the transcription factor AP2-G is required and sufficient for this switch, but how a particular sex is determined in a haploid parasite remains unknown. Using a global screen of barcoded mutants, we here identify genes essential for the formation of either male or female sexual forms and validate their importance for transmission. High-resolution single-cell transcriptomics of ten mutant parasites portrays the developmental bifurcation and reveals a regulatory cascade of putative gene functions in the determination and subsequent differentiation of each sex. A male-determining gene with a LOTUS/OST-HTH domain as well as the protein interactors of a female-determining zinc-finger protein indicate that germ-granule-like ribonucleoprotein complexes complement transcriptional processes in the regulation of both male and female development of a malaria parasite.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Keyword
- development
- differentiation
- malaria
- Plasmodium
- sex determination
- sex ratio
- single cell analysis
- transmission
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Russell, Andrew ...
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Sanderson, Theo
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Bushell, Ellen
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Talman, Arthur M ...
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Anar, Burcu
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Girling, Gareth
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show more...
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Hunziker, Mirjam
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Kent, Robyn S.
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Martin, Julie S.
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Metcalf, Tom
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Montandon, Ruddy
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Pandey, Vikash
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Pardo, Mercedes
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Roberts, A. Bret ...
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Sayers, Claire
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Schwach, Frank
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Choudhary, Jyoti ...
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Rayner, Julian C ...
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Voet, Thierry
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Modrzynska, Kata ...
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Waters, Andrew P ...
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Lawniczak, Mara ...
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Billker, Oliver
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Cell and Molecul ...
- Articles in the publication
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Cell Host and Mi ...
- By the university
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Umeå University