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Regulators of male ...
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Russell, Andrew J.C.Wellcome Sanger Institute, Hinxton, United Kingdom
(author)
Regulators of male and female sexual development are critical for the transmission of a malaria parasite
- Article/chapterEnglish2023
Publisher, publication year, extent ...
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Cell Press,2023
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electronicrdacarrier
Numbers
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LIBRIS-ID:oai:DiVA.org:umu-212243
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-212243URI
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https://doi.org/10.1016/j.chom.2022.12.011DOI
Supplementary language notes
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Language:English
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Summary in:English
Part of subdatabase
Classification
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
Notes
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Malaria transmission to mosquitoes requires a developmental switch in asexually dividing blood-stage parasites to sexual reproduction. In Plasmodium berghei, the transcription factor AP2-G is required and sufficient for this switch, but how a particular sex is determined in a haploid parasite remains unknown. Using a global screen of barcoded mutants, we here identify genes essential for the formation of either male or female sexual forms and validate their importance for transmission. High-resolution single-cell transcriptomics of ten mutant parasites portrays the developmental bifurcation and reveals a regulatory cascade of putative gene functions in the determination and subsequent differentiation of each sex. A male-determining gene with a LOTUS/OST-HTH domain as well as the protein interactors of a female-determining zinc-finger protein indicate that germ-granule-like ribonucleoprotein complexes complement transcriptional processes in the regulation of both male and female development of a malaria parasite.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Sanderson, TheoWellcome Sanger Institute, Hinxton, United Kingdom; Francis Crick Institute, 1 Midland Road, London, United Kingdom
(author)
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Bushell, EllenUmeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten),Wellcome Sanger Institute, Hinxton, United Kingdom(Swepub:umu)elbu0016
(author)
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Talman, Arthur M.Wellcome Sanger Institute, Hinxton, United Kingdom; MIVEGEC, University of Montpellier, IRD, CNRS, Montpellier, France
(author)
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Anar, BurcuWellcome Sanger Institute, Hinxton, United Kingdom
(author)
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Girling, GarethWellcome Sanger Institute, Hinxton, United Kingdom
(author)
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Hunziker, MirjamUmeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)(Swepub:umu)mihu0030
(author)
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Kent, Robyn S.Department of Microbiology and Molecular Genetics, University of Vermont Larner College of Medicine, VT, Burlington, United States
(author)
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Martin, Julie S.Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity, and Inflammation, University of Glasgow, Glasgow, United Kingdom
(author)
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Metcalf, TomWellcome Sanger Institute, Hinxton, United Kingdom
(author)
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Montandon, RuddyWellcome Sanger Institute, Hinxton, United Kingdom
(author)
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Pandey, VikashUmeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)(Swepub:umu)viku0018
(author)
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Pardo, MercedesThe Institute of Cancer Research, London, United Kingdom
(author)
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Roberts, A. BrettWellcome Centre for Integrative Parasitology, Institute of Infection, Immunity, and Inflammation, University of Glasgow, Glasgow, United Kingdom
(author)
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Sayers, ClaireUmeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)(Swepub:umu)clsa0011
(author)
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Schwach, FrankWellcome Sanger Institute, Hinxton, United Kingdom
(author)
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Choudhary, Jyoti S.The Institute of Cancer Research, London, United Kingdom
(author)
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Rayner, Julian C.Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom
(author)
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Voet, ThierryDepartment of Human Genetics, University of Leuven, KU Leuven, Leuven, Belgium; KU Leuven Institute for Single Cell Omics, LISCO, KU Leuven, Leuven, Belgium
(author)
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Modrzynska, Katarzyna K.Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity, and Inflammation, University of Glasgow, Glasgow, United Kingdom
(author)
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Waters, Andrew P.Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity, and Inflammation, University of Glasgow, Glasgow, United Kingdom
(author)
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Lawniczak, Mara K.N.Wellcome Sanger Institute, Hinxton, United Kingdom
(author)
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Billker, OliverUmeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Teknisk-naturvetenskaplig fakultet)(Swepub:umu)olbi0005
(author)
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Wellcome Sanger Institute, Hinxton, United KingdomWellcome Sanger Institute, Hinxton, United Kingdom; Francis Crick Institute, 1 Midland Road, London, United Kingdom
(creator_code:org_t)
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In:Cell Host and Microbe: Cell Press31:2, s. 305-319.e101931-31281934-6069
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Russell, Andrew ...
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Sanderson, Theo
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Bushell, Ellen
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Talman, Arthur M ...
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Anar, Burcu
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Girling, Gareth
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Hunziker, Mirjam
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Kent, Robyn S.
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Martin, Julie S.
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Metcalf, Tom
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Montandon, Ruddy
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Pandey, Vikash
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Pardo, Mercedes
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Roberts, A. Bret ...
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Sayers, Claire
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Schwach, Frank
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Choudhary, Jyoti ...
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Rayner, Julian C ...
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Voet, Thierry
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Modrzynska, Kata ...
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Waters, Andrew P ...
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Lawniczak, Mara ...
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Billker, Oliver
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