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Antibodies to leukotoxin A from the periodontal pathogen Aggregatibacter actinomycetemcomitans in patients at an increased risk of rheumatoid arthritis
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- Martinsson, Klara (author)
- Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten
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- Di Matteo, Andrea (author)
- Leeds Musculoskeletal Biomedical Research Unit, LTHT and Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, United Kingdom,Univ Leeds, LTHT, Leeds Musculoskeletal Biomed Res Unit, Leeds, England.;Univ Leeds, Leeds Inst Rheumat & Musculoskeletal Med, Leeds, England.
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- Öhman, Carina (author)
- Umeå universitet,Institutionen för odontologi,Aa-gruppen,Umeå Univ, Dept Odontol, Umeå, Sweden.
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- Frontiers Media S.A. 2023
- 2023
- English.
- In: Frontiers in Medicine. - : Frontiers Media S.A.. - 2296-858X. ; 10
- Journal article (peer-reviewed)
Abstract
Subject headings
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- Objectives: Periodontitis and underlying bacteria have been linked to the development of rheumatoid arthritis (RA). One suggested pathogen is Aggregatibacter actinomycetemcomitans (A.a.), which expresses leukotoxin A (LtxA) that can citrullinate human proteins, providing a possible trigger for the production of anti-citrullinated protein antibodies (ACPA). In this study, we seek to determine the presence of antibodies toward LtxA in patients at risk of developing RA.Methods: Two prospective observational patient cohorts (one Swedish and one British) with symptomatic at-risk patients were studied. Anti-LtxA antibodies were analyzed by a cell-based neutralization assay in baseline serum and compared to 100 Swedish blood donors that served as controls.Results: Serum anti-LtxA levels or positivity did not differ between patients and blood donors. In the British cohort, anti-LtxA was more prevalent among ACPA-positive arthralgia patients compared with ACPA-negative arthralgia cases (24% vs. 13%, p < 0.0001). In the Swedish at-risk cohort, anti-LtxA positive patients were at increased risk of progression to arthritis (hazard ratio (HR) 2.10, 95% CI 1.04–4.20), but this was not confirmed in the UK at-risk cohort (HR 0.99, CI 0.60–1.65).Conclusion: Serum anti-LtxA is not elevated before RA diagnosis, and associations with disease progression and ACPA levels differ between populations. Other features of the oral microbiome should be explored in upcoming periodontitis-related RA research.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reumatologi och inflammation (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Rheumatology and Autoimmunity (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Keyword
- ACPA
- Aggregatibacter actinomycetemcomitans
- rheumatoid arthritis
- progression
- periodontitis
- reumatologi
- rheumatology
- odontologi
- Odontology
Publication and Content Type
- ref (subject category)
- art (subject category)
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- Emery, Paul
- Kastbom, Alf
- Mankia, Kulveer
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