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Phenotyping asthma ...
Phenotyping asthma with airflow obstruction in middle-aged and older adults : a CADSET clinical research collaboration
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- Bertels, Xander (author)
- Department of Bioanalysis, Ghent University, Gent, Belgium; Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands
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- Edris, Ahmed (author)
- Department of Bioanalysis, Ghent University, Gent, Belgium; Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands
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- Garcia-Aymerich, Judith (author)
- Non-Communicable Diseases and Environment Programme, ISGlobal, Barcelona, Spain; Centro Investigaciones Biomédicas en Red (CIBERES), Instituto de Salud Carlos III, Madrid, Spain
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- Faner, Rosa (author)
- Centro Investigaciones Biomédicas en Red (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain; Department of Biomedical Sciences, University of Barcelona, Barcelona, Spain
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- Meteran, Howraman (author)
- Department of Respiratory Medicine, Copenhagen University Hospital-Amager and Hvidovre, Denmark; Environment, Occupation and Health, Danish Ramazzini Centre, Department of Public Health, Aarhus University, Aarhus, Denmark
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- Sigsgaard, Torben (author)
- Environment, Occupation and Health, Danish Ramazzini Centre, Department of Public Health, Aarhus University, Aarhus, Denmark
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- Alter, Peter (author)
- Department of Medicine, Pulmonary and Critical Care Medicine, Philipps University of Marburg, Marburg, Germany
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- Vogelmeier, Claus (author)
- Department of Medicine, Pulmonary and Critical Care Medicine, Philipps University of Marburg, Marburg, Germany; Department of Respiratory and Critical Care Medicine and Ludwig Boltzmann Institute for COPD and Respiratory Epidemiology, Otto Wagner Hospital, Vienna, Austria
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- Olvera, Nuria (author)
- Centro Investigaciones Biomédicas en Red (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain
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- Kermani, Nazanin Zounemat (author)
- National Heart and Lung Institute & Data Science Institute, Imperial College London, London, United Kingdom
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- Agusti, Alvar (author)
- Centro Investigaciones Biomédicas en Red (CIBERES), Instituto de Salud Carlos III, Madrid, Spain; Institut d'Investigacions Biomédiques August Pi i Sunyer (IDIBAPS), Hospital Clinic de Barcelona, Barcelona, Spain; Department of Medicine, University of Barcelona, Barcelona, Spain; Respiratory Institute, Hospital Clinic de Barcelona, Barcelona, Spain
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- Donaldson, Gavin C. (author)
- National Heart and Lung Institute & Data Science Institute, Imperial College London, London, United Kingdom
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- Wedzicha, Jadwiga A. (author)
- National Heart and Lung Institute & Data Science Institute, Imperial College London, London, United Kingdom
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- Brusselle, Guy G. (author)
- Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands; Department of Respiratory Medicine, Erasmus MC, Rotterdam, Netherlands; Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
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- Backman, Helena (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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- Rönmark, Eva (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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- Lindberg, Anne (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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- Vonk, Judith M. (author)
- Department of Epidemiology, University Medical Centre Groningen, Groningen, Netherlands; Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Centre Groningen, Groningen, Netherlands
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- Chung, Kian Fan (author)
- National Heart and Lung Institute & Data Science Institute, Imperial College London, London, United Kingdom
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- Adcock, Ian M. (author)
- National Heart and Lung Institute & Data Science Institute, Imperial College London, London, United Kingdom
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- van den Berge, Maarten (author)
- Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Centre Groningen, Groningen, Netherlands; Department of Pulmonology, University Medical Centre Groningen, Groningen, Netherlands
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- Lahousse, Lies (author)
- Department of Bioanalysis, Ghent University, Gent, Belgium; Department of Epidemiology, Erasmus MC, Rotterdam, Netherlands
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(creator_code:org_t)
- BMJ Publishing Group Ltd, 2023
- 2023
- English.
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In: BMJ open respiratory research. - : BMJ Publishing Group Ltd. - 2052-4439. ; 10:1
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https://doi.org/10.1...
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Abstract
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- BACKGROUND: The prevalence and clinical profile of asthma with airflow obstruction (AO) remain uncertain. We aimed to phenotype AO in population- and clinic-based cohorts.METHODS: This cross-sectional multicohort study included adults ≥50 years from nine CADSET cohorts with spirometry data (N=69 789). AO was defined as ever diagnosed asthma with pre-BD or post-BD FEV1/FVC <0.7 in population-based and clinic-based cohorts, respectively. Clinical characteristics and comorbidities of AO were compared with asthma without airflow obstruction (asthma-only) and chronic obstructive pulmonary disease (COPD) without asthma history (COPD-only). ORs for comorbidities adjusted for age, sex, smoking status and body mass index (BMI) were meta-analysed using a random effects model.RESULTS: The prevalence of AO was 2.1% (95% CI 2.0% to 2.2%) in population-based, 21.1% (95% CI 18.6% to 23.8%) in asthma-based and 16.9% (95% CI 15.8% to 17.9%) in COPD-based cohorts. AO patients had more often clinically relevant dyspnoea (modified Medical Research Council score ≥2) than asthma-only (+14.4 and +14.7 percentage points) and COPD-only (+24.0 and +5.0 percentage points) in population-based and clinic-based cohorts, respectively. AO patients had more often elevated blood eosinophil counts (>300 cells/µL), although only significant in population-based cohorts. Compared with asthma-only, AO patients were more often men, current smokers, with a lower BMI, had less often obesity and had more often chronic bronchitis. Compared with COPD-only, AO patients were younger, less often current smokers and had less pack-years. In the general population, AO patients had a higher risk of coronary artery disease than asthma-only and COPD-only (OR=2.09 (95% CI 1.26 to 3.47) and OR=1.89 (95% CI 1.10 to 3.24), respectively) and of depression (OR=1.41 (95% CI 1.19 to 1.67)), osteoporosis (OR=2.30 (95% CI 1.43 to 3.72)) and gastro-oesophageal reflux disease (OR=1.68 (95% CI 1.06 to 2.68)) than COPD-only, independent of age, sex, smoking status and BMI.CONCLUSIONS: AO is a relatively prevalent respiratory phenotype associated with more dyspnoea and a higher risk of coronary artery disease and elevated blood eosinophil counts in the general population compared with both asthma-only and COPD-only.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Lungmedicin och allergi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Respiratory Medicine and Allergy (hsv//eng)
Keyword
- Asthma
- Asthma Epidemiology
- Clinical Epidemiology
- COPD epidemiology
- Pulmonary Disease
- Chronic Obstructive
Publication and Content Type
- ref (subject category)
- art (subject category)
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Bertels, Xander
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Edris, Ahmed
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Garcia-Aymerich, ...
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Faner, Rosa
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Meteran, Howrama ...
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Sigsgaard, Torbe ...
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Alter, Peter
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Vogelmeier, Clau ...
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Olvera, Nuria
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Kermani, Nazanin ...
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Agusti, Alvar
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Donaldson, Gavin ...
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Wedzicha, Jadwig ...
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Brusselle, Guy G ...
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Backman, Helena
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Rönmark, Eva
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Lindberg, Anne
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Vonk, Judith M.
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Chung, Kian Fan
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Adcock, Ian M.
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van den Berge, M ...
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Lahousse, Lies
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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BMJ open respira ...
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Umeå University