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Adipokines are poss...
Adipokines are possible risk markers for aortic stenosis requiring surgery
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- Hansén, Nike (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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- Ljungberg, Johan (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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- Bergdahl, Ingvar (author)
- Umeå universitet,Enheten för biobanksforskning
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- Hultdin, Johan (author)
- Umeå universitet,Klinisk kemi
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- Näslund, Ulf (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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- Johansson, Bengt (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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- Söderberg, Stefan (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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(creator_code:org_t)
- Taylor & Francis, 2023
- 2023
- English.
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In: Scandinavian Cardiovascular Journal. - : Taylor & Francis. - 1401-7431 .- 1651-2006. ; 57:1
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https://umu.diva-por... (primary) (Raw object)
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Abstract
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- Objectives: Aortic stenosis (AS) is the most prevalent valvular heart disease among adults. The adipocyte-derived hormones, leptin and adiponectin, have profound metabolic actions. We examined whether these adipokines are independently associated with future aortic valve replacement (AVR).Design: In this longitudinal case-control study, we identified 336 cases who had undergone AVR due to AS, and who had previously participated in population-based health surveys. Two referents were matched to each case and leptin and adiponectin concentrations were analysed from stored baseline survey samples. Uni- and multivariable logistic regression analyses were used to estimate the risk of future AVR. An additional cohort was identified for validation including 106 cases with AVR and 212 matched referents.Results: Median age (interquartile range (IQR)) in years at survey was 59.9 (10.4) and at surgery 68.3 (12.7), and 48% were women. An elevated concentration of leptin was not associated with future AVR (odds ratio [95% confidence interval]) (1.10 [0.92–1.32]), although leptin was associated with a higher risk in patients with coronary artery disease (CAD) having more than 5 years between survey and AVR (1.41 [1.08–1.84]). Adiponectin was not associated with higher risk for future AVR (0.95 [0.82–1.11]), although after stratification for age, higher levels were associated with reduced risk for AVR in persons aged ≥60 years at surgery (0.79 [0.64–0.98]). In the validation study, leptin was associated with future AVR whereas adiponectin was not. None of the associations remained significant after adjustment for body mass index (BMI).Conclusions: The adipokine leptin may promote the development of AS.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- adiponectin
- Aortic stenosis
- fat mass
- leptin
- prospective study
- risk markers
Publication and Content Type
- ref (subject category)
- art (subject category)
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