Search: onr:"swepub:oai:DiVA.org:umu-214266" >
Imaging biomarkers ...
Imaging biomarkers are underutilised but highly predictive prognostic factors for the more fatal breast cancer subtypes
-
- Tabár, László (author)
- Falun Central Hospital, Falun, Sweden
-
- Dean, Peter B. (author)
- University of Turku, Yliopisto, Turun, Finland
-
- Tucker, F. Lee (author)
- Virginia Biomedical Laboratories, VA, Wirtz, United States
-
show more...
-
- Yen, Amy Ming-Fang (author)
- School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
-
- Chen, Sam Li-Sheng (author)
- School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
-
- Lin, Abbie Ting-Yu (author)
- Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
-
- Hsu, Chen-Yang (author)
- Daichung Hospital, Miaoli, Zhunan Township, Taiwan
-
- Munpolsri, Pattaranan (author)
- School of Oral Hygiene, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan
-
- Wu, Wendy Yi-Ying (author)
- Umeå universitet,Onkologi
-
- Smith, Robert A. (author)
- Early Cancer Detection Science, American Cancer Society, GA, Atlanta, United States
-
- Duffy, Stephen W. (author)
- Centre for Prevention, Detection and Diagnosis, Wolfson Institute of Population Health, Queen Mary University of London, Charterhouse Square London, United Kingdom
-
- Chen, Tony Hsiu-Hsi (author)
- Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
-
- Tarján, Miklós (author)
- Falun Central Hospital, Falun, Sweden
-
- Vörös, András (author)
- Department of Pathology, University of Szeged, Szeged, Hungary
-
show less...
-
(creator_code:org_t)
- Elsevier, 2023
- 2023
- English.
-
In: European Journal of Radiology. - : Elsevier. - 0720-048X .- 1872-7727. ; 166
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Purpose: The development and refinement of breast imaging modalities offer a wealth of diagnostic information such as imaging biomarkers, which are primarily the mammographic appearance of the various breast cancer subtypes. These are readily available preoperatively at the time of diagnosis and can enhance the prognostic value of currently used molecular biomarkers. In this study, we investigated the relative utility of the molecular and imaging biomarkers, both jointly and independently, when predicting long-term patient outcome according to the site of tumour origin.Methods: We evaluated the association of imaging biomarkers and conventional molecular biomarkers, (ER, PR, HER-2, Ki67), separately and combined, with long-term patient outcome in all breast cancer cases having complete data on both imaging and molecular biomarkers (n = 2236) diagnosed in our Institute during the period 2008–2019. Large format histopathology technique was used to document intra- and intertumoural heterogeneity and select the appropriate foci for evaluating molecular biomarkers.Results: The breast cancer imaging biomarkers were strongly predictive of long-term patient outcome. The molecular biomarkers were predictive of outcome only for unifocal acinar adenocarcinoma of the breast (AAB), but less reliable in the multifocal AAB cases due to variability of molecular biomarkers in the individual tumour foci. In breast cancer of mesenchymal origin (BCMO), conventionally termed classic invasive lobular carcinoma, and in cancers originating from the major lactiferous ducts (ductal adenocarcinoma of the breast, DAB), the molecular biomarkers misleadingly indicated favourable prognosis, whereas the imaging biomarkers in BCMO and DAB reliably indicated the high risk of breast cancer death. Among the 2236 breast cancer cases, BCMO and DAB comprised 21% of the breast cancer cases, but accounted for 45% of the breast cancer deaths.Conclusions: Integration of imaging biomarkers into the diagnostic workup of breast cancer yields a more precise, comprehensive and prognostically accurate diagnostic report. This is particularly necessary in multifocal AAB cases having intertumoural heterogeneity, in diffuse carcinomas (DAB and BCMO), and in cases with combined DAB and AAB. In such cases, the imaging biomarkers should be prioritised over molecular biomarkers in planning treatment because the latter fail to predict the severity of the disease. In combination with the use of the large section histopathology technique, imaging biomarkers help alleviate some of the current problems in breast cancer management, such as over- and under-assessment of disease extent, which carry the risk of overtreatment and undertreatment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Breast neoplasms
- Early detection of cancer
- Histopathology technology
- Imaging biomarkers
- Interdisciplinary communication
- Mammography
- Molecular biomarkers
- Pathologists
- Patient care
- Precision medicine
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Tabár, László
-
Dean, Peter B.
-
Tucker, F. Lee
-
Yen, Amy Ming-Fa ...
-
Chen, Sam Li-She ...
-
Lin, Abbie Ting- ...
-
show more...
-
Hsu, Chen-Yang
-
Munpolsri, Patta ...
-
Wu, Wendy Yi-Yin ...
-
Smith, Robert A.
-
Duffy, Stephen W ...
-
Chen, Tony Hsiu- ...
-
Tarján, Miklós
-
Vörös, András
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
European Journal ...
- By the university
-
Umeå University