Search: onr:"swepub:oai:DiVA.org:umu-214773" > Age at menopause an...
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000 | 12771naa a2200865 4500 | |
001 | oai:DiVA.org:umu-214773 | |
003 | SwePub | |
008 | 231009s2023 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:ba278b27-371f-400f-a562-eace75e61842 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2147732 URI |
024 | 7 | a https://doi.org/10.1161/JAHA.123.0302802 DOI |
024 | 7 | a https://lup.lub.lu.se/record/ba278b27-371f-400f-a562-eace75e618422 URI |
040 | a (SwePub)umud (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Tschiderer, Lenau Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Institute of Health Economics, Medical University of Innsbruck, Innsbruck, Austria4 aut |
245 | 1 0 | a Age at menopause and the risk of stroke :b observational and mendelian randomization analysis in 204 244 postmenopausal women |
264 | 1 | b American Heart Association Inc.c 2023 |
338 | a electronic2 rdacarrier | |
520 | a BACKGROUND: Observational studies have shown that women with an early menopause are at higher risk of stroke compared with women with a later menopause. However, associations with stroke subtypes are inconsistent, and the causality is unclear.METHODS AND RESULTS: We analyzed data of the UK Biobank and EPIC-CVD (European Prospective Investigation Into Cancer and Nutrition-Cardiovascular Diseases) study. A total of 204 244 postmenopausal women without a history of stroke at baseline were included (7883 from EPIC-CVD [5292 from the subcohort], 196 361 from the UK Biobank). Pooled mean baseline age was 58.9 years (SD, 5.8), and pooled mean age at menopause was 47.8 years (SD, 6.2). Over a median follow-up of 12.6 years (interquartile range, 11.8–13.3), 6770 women experienced a stroke (5155 ischemic strokes, 1615 hemorrhagic strokes, 976 intracerebral hemorrhages, and 639 subarachnoid hemorrhages). In multivariable adjusted observational Cox regression analyses, the pooled hazard ratios per 5 years younger age at menopause were 1.09 (95% CI, 1.07–1.12) for stroke, 1.09 (95% CI, 1.06–1.13) for ischemic stroke, 1.10 (95% CI, 1.04–1.16) for hemorrhagic stroke, 1.14 (95% CI, 1.08–1.20) for intracerebral hemorrhage, and 1.00 (95% CI, 0.84–1.20) for subarachnoid hemorrhage. When using 2-sample Mendelian randomization analysis, we found no statistically significant association between genetically proxied age at menopause and risk of any type of stroke.CONCLUSIONS: In our study, earlier age at menopause was related to a higher risk of stroke. We found no statistically significant association between genetically proxied age at menopause and risk of stroke, suggesting no causal relationship. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng |
653 | a age at menopause | |
653 | a Mendelian randomization analysis | |
653 | a observational analysis | |
653 | a stroke | |
653 | a age at menopause | |
653 | a Mendelian randomization analysis | |
653 | a observational analysis | |
653 | a stroke | |
700 | 1 | a Peters, Sanne A. E.u Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; The George Institute for Global Health, School of Public Health, Imperial College London, London, United Kingdom; The George Institute for Global Health, University of New South Wales, NSW, Sydney, Australia4 aut |
700 | 1 | a van der Schouw, Yvonne T.u Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands4 aut |
700 | 1 | a van Westing, Anniek C.u Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Division of Human Nutrition and Health, Wageningen University, Wageningen, Netherlands4 aut |
700 | 1 | a Tong, Tammy Y. N.u Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom4 aut |
700 | 1 | a Willeit, Peteru Institute of Health Economics, Medical University of Innsbruck, Innsbruck, Austria; Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom4 aut |
700 | 1 | a Seekircher, Lisau Institute of Health Economics, Medical University of Innsbruck, Innsbruck, Austria4 aut |
700 | 1 | a Moreno-Iribas, Conchiu Instituto de Salud Pública y Laboral de Navarra, Pamplona, Spain; Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain,CIBER Epidemiology and Public Health (CIBERESP)4 aut |
700 | 1 | a Huerta, José Maríau Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Department of Epidemiology, Murcia Regional Health Council-IMIB, Murcia, Spain,CIBER Epidemiology and Public Health (CIBERESP)4 aut |
700 | 1 | a Crous-Bou, Martau Unit of Nutrition and Cancer, Cancer Epidemiology Research Program, Catalan Institute of Oncology (ICO)– Bellvitge Biomedical Research Institute, (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain; Department of Epidemiology, Harvard T.H. Chan School of Public Health, MA, Boston, United States,Harvard University4 aut |
700 | 1 | a Söderholm, Martinu Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)med-ms8 |
700 | 1 | a Schulze, Matthias B.u Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany4 aut |
700 | 1 | a Johansson, Ceciliau Umeå University,Umeå universitet,Institutionen för folkhälsa och klinisk medicin4 aut0 (Swepub:umu)cejo0008 |
700 | 1 | a Själander, Sara,d 1981-u Umeå University,Umeå universitet,Institutionen för folkhälsa och klinisk medicin4 aut0 (Swepub:umu)saamer01 |
700 | 1 | a Heath, Alicia K.u SwedenDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom4 aut |
700 | 1 | a Macciotta, Alessandrau Centre for Biostatistics, Epidemiology, and Public Health (C-BEPH), Department of Clinical and Biological Sciences, University of Turin, Turin, Italy4 aut |
700 | 1 | a Dahm, Christina C.u Department of Public Health, Aarhus University, Aarhus, Denmark4 aut |
700 | 1 | a Ibsen, Daniel B.u Department of Public Health, Aarhus University, Aarhus, Denmark; Steno Diabetes Center Aarhus, Aarhus, Denmark; MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom; Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, Denmark4 aut |
700 | 1 | a Pala, Valeriau Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy4 aut |
700 | 1 | a Mellemkjær, Leneu Danish Cancer Society Research Center, Copenhagen, Denmark4 aut |
700 | 1 | a Burgess, Stephenu Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Heart and Lung Research Institute, University of Cambridge, Cambridge, United Kingdom; MRC Biostatistics Unit, School of Clinical Medicine, University of Cambridge, Cambridge, United Kingdom,Medical Research Council Biostatistics Unit4 aut |
700 | 1 | a Wood, Angelau Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom4 aut |
700 | 1 | a Kaaks, Rudolfu Division of Cancer Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany4 aut |
700 | 1 | a Katzke, Verenau Division of Cancer Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany4 aut |
700 | 1 | a Amiano, Pilaru Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain; Biodonostia Health Research Institute, Epidemiology of Chronic and Communicable Diseases Group, San Sebastian, Spain,CIBER Epidemiology and Public Health (CIBERESP)4 aut |
700 | 1 | a Rodriguez-Barranco, Miguelu Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Escuela Andaluza de Salud Pública (EASP), Granada, Spain; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain,CIBER Epidemiology and Public Health (CIBERESP),Andalusian School Of Public Health (EASP)4 aut |
700 | 1 | a Engström, Gunnaru Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)smi-gen |
700 | 1 | a Weiderpass, Elisabeteu International Agency for Research on Cancer, World Health Organization, Lyon, France4 aut |
700 | 1 | a Tjønneland, Anneu Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, Section of Environmental Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark4 aut |
700 | 1 | a Halkjær, Jytteu Danish Cancer Society Research Center, Copenhagen, Denmark4 aut |
700 | 1 | a Panico, Salvatoreu School of Medicine, Federico II University, Naples, Italy4 aut |
700 | 1 | a Danesh, Johnu BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; National Institute for Health and Care Research Cambridge Biomedical Research Centre, Cambridge University Hospitals, Cambridge, United Kingdom; The National Institute for Health and Care Research Blood and Transplant Unit (NIHR BTRU) in Donor Health and Genomics, University of Cambridge, Cambridge, United Kingdom; Human Genetics, Wellcome Sanger Institute, Saffron Walden, United Kingdom; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom; British Heart Foundation Centre of Research Excellence, Division of Cardiovascular Medicine, Addenbrooke’s Hospital, Cambridge, United Kingdom,Wellcome Trust Sanger Institute,Cambridge University Hospitals NHS Foundation Trust4 aut |
700 | 1 | a Butterworth, Adamu Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom; Heart and Lung Research Institute, University of Cambridge, Cambridge, United Kingdom; Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, United Kingdom; NIHR Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, United Kingdom; BHF Centre of Research Excellence, School of Clinical Medicine, Addenbrooke’s Hospital, Cambridge, United Kingdom4 aut |
700 | 1 | a Onland-Moret, N. Charlotteu Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands4 aut |
710 | 2 | a Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Institute of Health Economics, Medical University of Innsbruck, Innsbruck, Austriab Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; The George Institute for Global Health, School of Public Health, Imperial College London, London, United Kingdom; The George Institute for Global Health, University of New South Wales, NSW, Sydney, Australia4 org |
773 | 0 | t Journal of the American Heart Associationd : American Heart Association Inc.g 12:18q 12:18x 2047-9980 |
856 | 4 | u https://doi.org/10.1161/JAHA.123.030280y Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1803336/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u http://dx.doi.org/10.1161/JAHA.123.030280x freey FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-214773 |
856 | 4 8 | u https://doi.org/10.1161/JAHA.123.030280 |
856 | 4 8 | u https://lup.lub.lu.se/record/ba278b27-371f-400f-a562-eace75e61842 |
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