Search: onr:"swepub:oai:DiVA.org:umu-214977" >
Characterising the ...
Characterising the covariance pattern between lifestyle factors and structural brain measures : a multivariable replication study of two independent ageing cohorts
-
- Demnitz, Naiara (author)
- Danish Research Centre for Magnetic Resonance, centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital–Amager and Hvidovre, Hvidovre, Denmark
-
- Hulme, Oliver J. (author)
- Danish Research Centre for Magnetic Resonance, centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital–Amager and Hvidovre, Hvidovre, Denmark; London Mathematical Laboratory, London, United Kingdom; Department of Psychology, University of Copenhagen, Copenhagen, Denmark
-
- Siebner, Hartwig R. (author)
- Danish Research Centre for Magnetic Resonance, centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital–Amager and Hvidovre, Hvidovre, Denmark; Department of Neurology, Copenhagen University Hospital–Bispebjerg and Frederiksberg, Copenhagen, Denmark; Institute for Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark
-
show more...
-
- Kjaer, Michael (author)
- Institute of Sports Medicine Copenhagen (ISMC), Copenhagen University Hospital–Bispebjerg and Frederiksberg, Copenhagen, Denmark; Center for Healthy Aging, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
-
- Ebmeier, Klaus P. (author)
- Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, United Kingdom
-
- Boraxbekk, Carl-Johan, 1980- (author)
- Umeå universitet,Institutionen för strålningsvetenskaper,Umeå centrum för funktionell hjärnavbildning (UFBI),Danish Research Centre for Magnetic Resonance, centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital–Amager and Hvidovre, Hvidovre, Denmark; Department of Neurology, Copenhagen University Hospital–Bispebjerg and Frederiksberg, Copenhagen, Denmark; Institute for Clinical Medicine, Faculty of Medical and Health Sciences, University of Copenhagen, Copenhagen, Denmark; Institute of Sports Medicine Copenhagen (ISMC), Copenhagen University Hospital–Bispebjerg and Frederiksberg, Copenhagen, Denmark
-
- Gillan, Claire M. (author)
- School of Psychology, Trinity College Dublin, Dublin, Ireland; Global Brain Health Institute, Trinity College Dublin, Dublin, Ireland
-
show less...
-
(creator_code:org_t)
- Elsevier, 2023
- 2023
- English.
-
In: Neurobiology of Aging. - : Elsevier. - 0197-4580 .- 1558-1497. ; 131, s. 115-123
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://umu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Modifiable lifestyle factors have been shown to promote healthy brain ageing. However, studies have typically focused on a single factor at a time. Given that lifestyle factors do not occur in isolation, multivariable analyses provide a more realistic model of the lifestyle-brain relationship. Here, canonical correlation analyses (CCA) examined the relationship between nine lifestyle factors and seven MRI-derived indices of brain structure. The resulting covariance pattern was further explored with Bayesian regressions. CCA analyses were first conducted on a Danish cohort of older adults (n = 251) and then replicated in a British cohort (n = 668). In both cohorts, the latent factors of lifestyle and brain structure were positively correlated (UK: r =.37, p < 0.001; Denmark: r =.27, p < 0.001). In the cross-validation study, the correlation between lifestyle-brain latent factors was r =.10, p = 0.008. However, the pattern of associations differed between datasets. These findings suggest that baseline characterisation and tailoring towards the study sample may be beneficial for achieving targeted lifestyle interventions.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Keyword
- Magnetic resonance imaging (MRI)
- Modifiable lifestyle factors
- Old age
- White matter hyperintensities
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database