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  • Renman, DavidUmeå universitet,Kirurgi (author)

Association of pre-diagnostic physical exercise and peri-diagnostic body composition with mortality in non-metastatic colorectal cancer

  • Article/chapterEnglish2023

Publisher, publication year, extent ...

  • Springer Nature,2023
  • electronicrdacarrier

Numbers

  • LIBRIS-ID:oai:DiVA.org:umu-215081
  • https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-215081URI
  • https://doi.org/10.1007/s00384-023-04536-0DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:ref swepub-contenttype
  • Subject category:art swepub-publicationtype

Notes

  • Purpose: Sarcopenia and myosteatosis, quantified via computed tomography (CT), are associated with poor colorectal cancer outcomes. These body composition estimates can be influenced by physical exercise. We explored the correlation between pre-diagnostic physical exercise, body composition close to diagnosis, and the combined prognosis impact of these factors.Methods: We studied 519 stage I–III colorectal cancer (CRC) cases diagnosed 2000–2016 with pre-diagnostic self-reported recreational physical exercise data collected in the prospective, population-based Northern Sweden Health and Disease Study, and CT-estimated skeletal muscle index (SMI) or skeletal muscle density (SMD). Risk estimates were calculated by multivariable logistic regression and Cox proportional hazards models.Results: No association was seen between low pre-diagnostic physical exercise and sarcopenia/myosteatosis in the multivariable model adjusted for age, sex, educational level, tumor stage, and tumor location. In multivariable Cox regression models, the combination of low pre-diagnostic physical exercise and either sarcopenia or myosteatosis at the time of diagnosis was associated with cancer-specific mortality compared to the reference group of high physical exercise combined with no sarcopenia/myosteatosis (adjusted HR 1.94 95% CI 1.00–3.76 for sarcopenia and adjusted HR 2.39 95% CI 1.16–4.94 for myosteatosis).Conclusions: The combined presence of low pre-diagnostic physical exercise and sarcopenia or myosteatosis was associated with increased CRC-specific mortality. Despite the positive effect on prognosis, physical exercise did not alter body composition estimates at diagnosis, which could indicate attenuation from other factors.

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Added entries (persons, corporate bodies, meetings, titles ...)

  • van Guelpen, BethanyUmeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi(Swepub:umu)beyvan99 (author)
  • Anderson, FredrickUmeå universitet,Onkologi(Swepub:umu)fran0028 (author)
  • Axelsson, Jan,1966-Umeå universitet,Radiofysik(Swepub:umu)jaax0004 (author)
  • Riklund, Katrine,MD, PhD, Professor,1963-Umeå universitet,Diagnostisk radiologi(Swepub:umu)kaah0001 (author)
  • Strigård, KarinUmeå universitet,Institutionen för kirurgisk och perioperativ vetenskap(Swepub:umu)kast0065 (author)
  • Palmqvist, RichardUmeå universitet,Patologi(Swepub:umu)ripa0001 (author)
  • Gunnarsson, UlfUmeå universitet,Institutionen för kirurgisk och perioperativ vetenskap(Swepub:umu)ulgu0014 (author)
  • Gylling, Björn,1978-Umeå universitet,Patologi(Swepub:umu)bjgy0001 (author)
  • Umeå universitetKirurgi (creator_code:org_t)

Related titles

  • In:International Journal of Colorectal Disease: Springer Nature38:10179-19581432-1262

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