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Frailty is associat...
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Haas, Lenneke E MDiakonessenhuis Utrecht, Netherlands,Univ Tripoli, Libya
(author)
Frailty is associated with long-term outcome in patients with sepsis who are over 80 years old : results from an observational study in 241 European ICUs
- Article/chapterEnglish2021
Publisher, publication year, extent ...
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2021-03-20
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Oxford University Press,2021
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printrdacarrier
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LIBRIS-ID:oai:DiVA.org:umu-215809
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-215809URI
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https://doi.org/10.1093/ageing/afab036DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-182809URI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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BACKGROUND: Sepsis is one of the most frequent reasons for acute intensive care unit (ICU) admission of very old patients and mortality rates are high. However, the impact of pre-existing physical and cognitive function on long-term outcome of ICU patients ≥ 80 years old (very old intensive care patients (VIPs)) with sepsis is unclear.OBJECTIVE: To investigate both the short- and long-term mortality of VIPs admitted with sepsis and assess the relation of mortality with pre-existing physical and cognitive function.DESIGN: Prospective cohort study.SETTING: 241 ICUs from 22 European countries in a six-month period between May 2018 and May 2019.SUBJECTS: Acutely admitted ICU patients aged ≥80 years with sequential organ failure assessment (SOFA) score ≥ 2.METHODS: Sepsis was defined according to the sepsis 3.0 criteria. Patients with sepsis as an admission diagnosis were compared with other acutely admitted patients. In addition to patients' characteristics, disease severity, information about comorbidity and polypharmacy and pre-existing physical and cognitive function were collected.RESULTS: Out of 3,596 acutely admitted VIPs with SOFA score ≥ 2, a group of 532 patients with sepsis were compared to other admissions. Predictors for 6-month mortality were age (per 5 years): Hazard ratio (HR, 1.16 (95% confidence interval (CI), 1.09-1.25, P < 0.0001), SOFA (per one-point): HR, 1.16 (95% CI, 1.14-1.17, P < 0.0001) and frailty (CFS > 4): HR, 1.34 (95% CI, 1.18-1.51, P < 0.0001).CONCLUSIONS: There is substantial long-term mortality in VIPs admitted with sepsis. Frailty, age and disease severity were identified as predictors of long-term mortality in VIPs admitted with sepsis.
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Added entries (persons, corporate bodies, meetings, titles ...)
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Boumendil, ArianeHop St Antoine, France
(author)
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Flaatten, HansUniv Bergen, Norway
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Guidet, BertrandSorbonne Univ, France
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Ibarz, MercedesUniv Hosp Sagrat Cor Barcelona, Spain
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Jung, ChristianHeinrich Heine Univ, Germany
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Moreno, RuiUniv Lisboa Cent, Portugal
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Morandi, AlessandroHosp Ancelle, Italy; Parc Sanitari Pere Virgili, Spain; Vail dHebron Inst Res, Spain
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Andersen, Finn HAlesund Hosp, Norway; NTNU, Norway
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Zafeiridis, TilemachosGen Hosp Larissa, Greece
(author)
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Walther, StenRegion Östergötland, Thorax-kärlkliniken i Östergötland(Swepub:liu)stewa50
(author)
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Oeyen, SandraGhent Univ Hosp, Belgium
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Leaver, SusannahNHS Fdn Trust, England
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Watson, XimenaSt Georges Univ Hosp, England
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Boulanger, CaroleRoyal Devon & Exeter NHS Fdn Trust, England
(author)
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Szczeklik, WojciechJagiellonian Univ Med Coll, Poland
(author)
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Schefold, Joerg CUniv Bern, Switzerland
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Cecconi, MaurizioIRCCS, Italy; Humanitas Univ, Italy
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Marsh, BrianMater Misericordiae Univ Hosp, Ireland
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Joannidis, MichaelMed Univ Innsbruck, Austria
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Nalapko, YuriyICU, Ukraine
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Elhadi, Muhammed
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Fjølner, JesperAarhus Univ Hosp, Denmark
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Artigas, AntonioAutonomous Univ Barcelona, Spain
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de Lange, Dylan WUniv Utrecht, Netherlands
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Brorsson, CamillaUmeå universitet,Anestesiologi och intensivvård,VIP2 study group(Swepub:umu)brca0001
(contributor)
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Diakonessenhuis Utrecht, NetherlandsUniv Tripoli, Libya
(creator_code:org_t)
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In:Age and Ageing: Oxford University Press50:5, s. 1719-17270002-07291468-2834
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Haas, Lenneke E ...
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Boumendil, Arian ...
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Flaatten, Hans
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Guidet, Bertrand
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Ibarz, Mercedes
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Jung, Christian
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Moreno, Rui
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Morandi, Alessan ...
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Andersen, Finn H
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Zafeiridis, Tile ...
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Walther, Sten
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Oeyen, Sandra
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Leaver, Susannah
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Watson, Ximena
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Boulanger, Carol ...
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Szczeklik, Wojci ...
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Schefold, Joerg ...
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Cecconi, Maurizi ...
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Marsh, Brian
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Joannidis, Micha ...
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Nalapko, Yuriy
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Elhadi, Muhammed
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Fjølner, Jesper
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Artigas, Antonio
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de Lange, Dylan ...
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Brorsson, Camill ...
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Age and Ageing
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Umeå University
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Linköping University