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Prospective and Men...
Prospective and Mendelian randomization analyses on the association of circulating fatty acid binding protein 4 (FABP-4) and risk of colorectal cancer
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- Nimptsch, Katharina (author)
- Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany
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- Aleksandrova, Krasimira (author)
- Department Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology, Bremen, Germany; Faculty of Human and Health Sciences, University of Bremen, Bremen, Germany
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- Pham, Thu Thi (author)
- Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany; Charité - Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin, Germany
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- Papadimitriou, Nikos (author)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France
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- Janke, Jürgen (author)
- Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany; Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Biobank Technology Platform, Berlin, Germany
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- Christakoudi, Sofia (author)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom; Department of Inflammation Biology, School of Immunology and Microbial Sciences, King’s College London, London, United Kingdom
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- Heath, Alicia (author)
- Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom
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- Olsen, Anja (author)
- Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, University of Århus, Århus, Denmark
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- Tjønneland, Anne (author)
- Danish Cancer Society Research Center, Copenhagen, Denmark; Department of Public Health, University of Copenhagen, Copenhagen, Denmark
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- Schulze, Matthias B. (author)
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nutehtal, Germany; Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany
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- Katzke, Verena (author)
- Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- Kaaks, Rudolf (author)
- Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany
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- van Guelpen, Bethany (author)
- Umeå universitet,Wallenberg centrum för molekylär medicin vid Umeå universitet (WCMM),Onkologi
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- Harbs, Justin (author)
- Umeå universitet,Onkologi
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- Palli, Domenico (author)
- Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network (ISPRO), Florence, Italy
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- Macciotta, Alessandra (author)
- Department of Clinical and Biological Sciences, University of Turin, Turin, Italy
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- Pasanisi, Fabrizio (author)
- Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy
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- Yohar, Sandra Milena Colorado (author)
- Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Research Group on Demography and Health, National Faculty of Public Health, University of Antioquia, Medellín, Colombia
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- Guevara, Marcela (author)
- CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Instituto de Salud Pública de Navarra, Pamplona, Spain; Navarra Institute for Health Research (IdiSNA), Pamplona, Spain
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- Amiano, Pilar (author)
- CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Ministry of Health of the Basque Government, Sub Directorate for Public Health and Addictions of Gipuzkoa, San Sebastian, Spain; Epidemiology of Chronic and Communicable Diseases Group, Biodonostia Health Research Institute, San Sebastián, Spain
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- Grioni, Sara (author)
- Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori di Milano, Milan, Italy
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- Jakszyn, Paula Gabriela (author)
- Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain; Blanquerna School of Health Sciences, Ramon Llull University, Barcelona, Spain
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- Figueiredo, Jane C. (author)
- Cedars-Sinai Medical Center Samuel Oschin Comprehensive Cancer Institute, CA, Los Angeles, United States
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- Samadder, N. Jewel (author)
- Division of Gastroenterology and Hepatology, Mayo Clinic Comprehensive Cancer Center, Mayo Clinic, AZ, Phoenix, United States
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- Li, Christopher I. (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States
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- Moreno, Victor (author)
- CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Oncology Data Analytics Program, Catalan Institute of Oncology-IDIBELL, L’Hospitalet de Llobregat, Barcelona, Spain; Department of Clinical Sciences, Faculty of Medicine and Health Sciences and Universitat de Barcelona Institute of Complex Systems (UBICS), University of Barcelona (UB), L’Hospitalet de Llobregat, Barcelona, Spain
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- Potter, John D. (author)
- Public Health Sciences Division, Fred Hutchinson Cancer Center, WA, Seattle, United States; Research Centre for Hauora and Health, Massey University, Wellington, New Zealand
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- Schoen, Robert E. (author)
- Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, PA, Pittsburgh, United States
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- Um, Caroline Y. (author)
- Department of Population Science, American Cancer Society, GA, Atlanta, United States
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- Weiderpass, Elisabete (author)
- International Agency for Research on Cancer, World Health Organization, Lyon, France
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- Jenab, Mazda (author)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France
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- Gunter, Marc J. (author)
- Nutrition and Metabolism Branch, International Agency for Research on Cancer (IARC-WHO), Lyon, France
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- Pischon, Tobias (author)
- Molecular Epidemiology Research Group, Max Delbrück Center for Molecular Medicine (MDC), Berlin, Germany; Charité - Universitaetsmedizin Berlin, Corporate Member of Freie Universitaet Berlin, Humboldt-Universitaet zu Berlin, Berlin, Germany; Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Biobank Technology Platform, Berlin, Germany
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(creator_code:org_t)
- BioMed Central (BMC), 2023
- 2023
- English.
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In: BMC Medicine. - : BioMed Central (BMC). - 1741-7015. ; 21:1
- Related links:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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Abstract
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- Background: Fatty acid binding protein 4 (FABP-4) is a lipid-binding adipokine upregulated in obesity, which may facilitate fatty acid supply for tumor growth and promote insulin resistance and inflammation and may thus play a role in colorectal cancer (CRC) development. We aimed to investigate the association between circulating FABP-4 and CRC and to assess potential causality using a Mendelian randomization (MR) approach.Methods: The association between pre-diagnostic plasma measurements of FABP-4 and CRC risk was investigated in a nested case-control study in 1324 CRC cases and the same number of matched controls within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A two-sample Mendelian randomization study was conducted based on three genetic variants (1 cis, 2 trans) associated with circulating FABP-4 identified in a published genome-wide association study (discovery n = 20,436) and data from 58,131 CRC cases and 67,347 controls in the Genetics and Epidemiology of Colorectal Cancer Consortium, Colorectal Cancer Transdisciplinary Study, and Colon Cancer Family Registry.Results: In conditional logistic regression models adjusted for potential confounders including body size, the estimated relative risk, RR (95% confidence interval, CI) per one standard deviation, SD (8.9 ng/mL) higher FABP-4 concentration was 1.01 (0.92, 1.12) overall, 0.95 (0.80, 1.13) in men and 1.09 (0.95, 1.25) in women. Genetically determined higher FABP-4 was not associated with colorectal cancer risk (RR per FABP-4 SD was 1.10 (0.95, 1.27) overall, 1.03 (0.84, 1.26) in men and 1.21 (0.98, 1.48) in women). However, in a cis-MR approach, a statistically significant association was observed in women (RR 1.56, 1.09, 2.23) but not overall (RR 1.23, 0.97, 1.57) or in men (0.99, 0.71, 1.37).Conclusions: Taken together, these analyses provide no support for a causal role of circulating FABP-4 in the development of CRC, although the cis-MR provides some evidence for a positive association in women, which may deserve to be investigated further.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- Colorectal cancer
- FABP-4
- Mendelian randomization
Publication and Content Type
- ref (subject category)
- art (subject category)
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Nimptsch, Kathar ...
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Aleksandrova, Kr ...
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Pham, Thu Thi
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Papadimitriou, N ...
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Janke, Jürgen
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Christakoudi, So ...
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show more...
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Heath, Alicia
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Olsen, Anja
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Tjønneland, Anne
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Schulze, Matthia ...
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Katzke, Verena
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Kaaks, Rudolf
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van Guelpen, Bet ...
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Harbs, Justin
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Palli, Domenico
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Macciotta, Aless ...
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Pasanisi, Fabriz ...
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Yohar, Sandra Mi ...
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Guevara, Marcela
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Amiano, Pilar
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Grioni, Sara
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Jakszyn, Paula G ...
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Figueiredo, Jane ...
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Samadder, N. Jew ...
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Li, Christopher ...
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Moreno, Victor
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Potter, John D.
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Schoen, Robert E ...
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Um, Caroline Y.
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Weiderpass, Elis ...
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Jenab, Mazda
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Gunter, Marc J.
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Pischon, Tobias
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- MEDICAL AND HEALTH SCIENCES
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BMC Medicine
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Umeå University