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Histopathology-vali...
Histopathology-validated lesion detection rates of clinically significant prostate cancer with mpMRI, [68Ga]PSMA-11-PET and [11C]Acetate-PET
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- Sandgren, Kristina (author)
- Umeå universitet,Radiofysik
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- Strandberg, Sara, 1976- (author)
- Umeå universitet,Diagnostisk radiologi
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- Jonsson, Joakim, 1984- (author)
- Umeå universitet,Radiofysik
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- Grefve, Josefine (author)
- Umeå universitet,Radiofysik
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- Keeratijarut Lindberg, Angsana (author)
- Umeå universitet,Radiofysik
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- Nilsson, Erik (author)
- Umeå universitet,Radiofysik
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- Bergh, Anders (author)
- Umeå universitet,Patologi
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- Söderkvist, Karin (author)
- Umeå universitet,Onkologi
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- Thellenberg-Karlsson, Camilla, 1972- (author)
- Umeå universitet,Onkologi
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- Friedrich, Bengt (author)
- Umeå universitet,Urologi och andrologi
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- Widmark, Anders (author)
- Umeå universitet,Onkologi
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- Blomqvist, Lennart (author)
- Karolinska Institutet
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- Loegager, Vibeke Berg (author)
- Department of Radiology, Copenhagen University Hospital in Herlev, Herlev, Denmark
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- Axelsson, Jan, 1966- (author)
- Umeå universitet,Radiofysik
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- Ögren, Mattias (author)
- Umeå universitet,Diagnostisk radiologi
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- Ögren, Margareta (author)
- Umeå universitet,Diagnostisk radiologi
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- Nyholm, Tufve (author)
- Umeå universitet,Radiofysik
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- Riklund, Katrine, MD, PhD, Professor, 1963- (author)
- Umeå universitet,Diagnostisk radiologi
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(creator_code:org_t)
- Lippincott Williams & Wilkins, 2023
- 2023
- English.
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In: Nuclear medicine communications. - : Lippincott Williams & Wilkins. - 0143-3636 .- 1473-5628. ; 44:11, s. 997-1004
- Related links:
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https://doi.org/10.1...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Objective: PET/CT and multiparametric MRI (mpMRI) are important diagnostic tools in clinically significant prostate cancer (csPC). The aim of this study was to compare csPC detection rates with [68Ga]PSMA-11-PET (PSMA)-PET, [11C] Acetate (ACE)-PET, and mpMRI with histopathology as reference, to identify the most suitable imaging modalities for subsequent hybrid imaging. An additional aim was to compare inter-reader variability to assess reproducibility.Methods: During 2016–2019, all study participants were examined with PSMA-PET/mpMRI and ACE-PET/CT prior to radical prostatectomy. PSMA-PET, ACE-PET and mpMRI were evaluated separately by two observers, and were compared with histopathology-defined csPC. Statistical analyses included two-sided McNemar test and index of specific agreement.Results: Fifty-five study participants were included, with 130 histopathological intraprostatic lesions >0.05 cc. Of these, 32% (42/130) were classified as csPC with ISUP grade ≥2 and volume >0.5 cc. PSMA-PET and mpMRI showed no difference in performance (P = 0.48), with mean csPC detection rate of 70% (29.5/42) and 74% (31/42), respectively, while with ACE-PET the mean csPC detection rate was 37% (15.5/42). Interobserver agreement was higher with PSMA-PET compared to mpMRI [79% (26/33) vs 67% (24/38)]. Including all detected lesions from each pair of observers, the detection rate increased to 90% (38/42) with mpMRI, and 79% (33/42) with PSMA-PET.Conclusion: PSMA-PET and mpMRI showed high csPC detection rates and superior performance compared to ACE-PET. The interobserver agreement indicates higher reproducibility with PSMA-PET. The combined result of all observers in both PSMA-PET and mpMRI showed the highest detection rate, suggesting an added value of a hybrid imaging approach.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- acetate-PET
- detection rate
- intraprostatic lesion
- multiparametric MRI
- prostate cancer
- PSMA-PET
Publication and Content Type
- ref (subject category)
- art (subject category)
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Sandgren, Kristi ...
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Strandberg, Sara ...
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Jonsson, Joakim, ...
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Grefve, Josefine
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Keeratijarut Lin ...
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Nilsson, Erik
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Bergh, Anders
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Söderkvist, Kari ...
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Thellenberg-Karl ...
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Friedrich, Bengt
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Widmark, Anders
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Blomqvist, Lenna ...
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Loegager, Vibeke ...
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Axelsson, Jan, 1 ...
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Ögren, Mattias
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Ögren, Margareta
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Nyholm, Tufve
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Riklund, Katrine ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Radiology Nuclea ...
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Nuclear medicine ...
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Umeå University
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Karolinska Institutet