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Sex-specific time t...
Sex-specific time trends of long-term graft survival after kidney transplantation : a registry-based study
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- Nasic, Salmir (author)
- Department of Molecular and Clinical Medicine, Institute of Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; Research, Education, Development and Innovation Department, Skaraborg Hospital, Skövde, Sweden
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- Peters, Björn (author)
- Department of Molecular and Clinical Medicine, Institute of Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; Department of Nephrology, Skaraborg Hospital, Skövde, Sweden
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- Stegmayr, Bernd, 1949- (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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- Kenne Sarenmalm, Elisabeth (author)
- Research, Education, Development and Innovation Department, Skaraborg Hospital, Skövde, Sweden; Institute of Health and Care Sciences, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden
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- Afghahi, Henri (author)
- Department of Molecular and Clinical Medicine, Institute of Medicine, The Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden; Department of Nephrology, Skaraborg Hospital, Skövde, Sweden
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- Eriksson, Marie, Professor (author)
- Umeå universitet,Statistik
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(creator_code:org_t)
- Taylor & Francis, 2023
- 2023
- English.
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In: Renal failure. - : Taylor & Francis. - 0886-022X .- 1525-6049. ; 45:2
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https://umu.diva-por... (primary) (Raw object)
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Abstract
Subject headings
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- Background: Sex-specific trends over time with respect to kidney graft survival have scarcely been described in earlier studies. The present study aimed to examine whether kidney graft survival differs between women and men over time.Methods: This study was based on prospectively collected data extracted from a quality registry including all kidney transplant patients between January 1965 and September 2017 at the transplantation center of a university hospital in Sweden. The transplantation center serves a population of approximately 3.5 million inhabitants. Only the first graft for each patient was included in the study resulting in 4698 transplantations from unique patients (37% women, 63% men). Patients were followed-up until graft failure, death, or the end of the study. Death-censored graft survival analysis after kidney transplantation (KT) was performed using Kaplan-Meier analysis with log-rank test, and analysis adjusted for confounders was performed using multivariable Cox regression analysis.Results: Median age at transplantation was 48 years (quartiles 36–57 years) and was similar for women and men. Graft survival was analyzed separately in four transplantation periods that represented various immunosuppressive regimes (1965-1985, 1986–1995, 1996–2005, and 2006–2017). Sex differences in graft survival varied over time (sex-by-period interaction, p = 0.026). During the three first periods, there were no significant sex differences in graft survival. However, during the last period, women had shorter graft survival (p = 0.022, hazard ratio (HR) 1.71, 95% confidence interval (CI) 1.1–2.7, adjusted for covariates). Biopsy-proven rejections were more common in women.Conclusions: In this registry-based study, women had shorter graft survival than men during the last observation period (years 2006–2017).
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kirurgi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Surgery (hsv//eng)
Keyword
- Kidney graft survival
- kidney transplants
- sex-specific trends
Publication and Content Type
- ref (subject category)
- art (subject category)
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