Search: onr:"swepub:oai:DiVA.org:umu-217213" >
Accelerometer-measu...
Accelerometer-measured sedentary behavior patterns, brain structure, and cognitive function in dementia-free older adults : a population-based study
-
- Han, Xiaolei (author)
- Department of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
-
- Song, Lin (author)
- Department of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
-
- Li, Yuanjing (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI)
-
show more...
-
- Dong, Yi (author)
- Department of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
-
- Liu, Rui (author)
- Department of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
-
- Han, Qi (author)
- Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
-
- Wang, Xiaojie (author)
- Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
-
- Mao, Ming (author)
- Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
-
- Cong, Lin (author)
- Department of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
-
- Tang, Shi (author)
- Department of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
-
- Hou, Tingting (author)
- Department of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
-
- Zhang, Qinghua (author)
- Department of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
-
- Liu, Cuicui (author)
- Karolinska Institutet
-
- Han, Xiaodong (author)
- Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
-
- Shi, Lin (author)
- BrainNow Research Institute, Shenzhen, Guangdong, China; Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Hong Kong, Hong Kong
-
- Nyberg, Lars, 1966- (author)
- Umeå universitet,Diagnostisk radiologi
-
- Launer, Lenore J. (author)
- Intramural Research Program, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, National Institutes of Health, MD, Baltimore, United States
-
- Wang, Yongxiang (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Shandong First Medical University, China; Shandong Academy of Medical Sciences, China
-
- Du, Yifeng (author)
- Department of Neurology, Shandong Provincial Hospital, Shandong First Medical University, Jinan, Shandong, China; Department of Neurology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong, China
-
- Qiu, Chengxuan (author)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Shandong First Medical University, China; Shandong Academy of Medical Sciences, China
-
show less...
-
(creator_code:org_t)
- IOS Press, 2023
- 2023
- English.
-
In: Journal of Alzheimer's Disease. - : IOS Press. - 1387-2877 .- 1875-8908. ; 96:2, s. 657-668
- Related links:
-
https://doi.org/10.3...
-
show more...
-
https://umu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.3...
-
https://urn.kb.se/re...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Background: Sedentary behavior is associated with cognitive impairment, but the neuropathological mechanisms underlying their associations are poorly understood.Objective: To investigate the associations of accelerometer-measured sedentary behavior patterns with brain structure and cognition, and further to explore the potential mechanisms.Methods: This community-based study included 2,019 older adults (age≥60 years, 59% women) without dementia derived from participants in the baseline examination of MIND-China (2018-2020). We assessed sedentary parameters using an accelerometer and cognitive function using a neuropsychological test battery. Structural brain markers were assessed on the structural brain MRI scans in a subsample (n = 1,009). Data were analyzed using the general linear, isotemporal substitution, and mediation models.Results: In the total sample (n = 2,019), adjusting for multiple covariates and moderate-to-vigorous-intensity physical activity, longer mean sedentary bout duration was linearly related with lower z-scores of global cognition, verbal fluency, and memory (ptrend < 0.05), whereas greater total sedentary time was linearly associated with lower z-scores of global cognition, verbal fluency, and memory only among individuals with long sedentary time (>10 h/day) (ptrend < 0.05); Breaking up sedentary time with same amount of light-intensity physical activity was significantly associated with higher verbal fluency and memory z-scores (p < 0.05). In the MRI subsample (n = 1,009), separately entering structural brain MRI markers into the mediation models substantially attenuated the associations of mean sedentary bout duration with global cognition, verbal fluency, and memory z-scores.Conclusion: Prolonged uninterrupted sedentary time is associated with poor global cognition, memory, and verbal fluency among rural older adults, and structural brain markers could partially mediate the association.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Accelerometer
- Alzheimer's disease
- brain aging
- cognition
- magnetic resonance imaging
- population-based study
- sedentary behavior patterns
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Han, Xiaolei
-
Song, Lin
-
Li, Yuanjing
-
Dong, Yi
-
Liu, Rui
-
Han, Qi
-
show more...
-
Wang, Xiaojie
-
Mao, Ming
-
Cong, Lin
-
Tang, Shi
-
Hou, Tingting
-
Zhang, Qinghua
-
Liu, Cuicui
-
Han, Xiaodong
-
Shi, Lin
-
Nyberg, Lars, 19 ...
-
Launer, Lenore J ...
-
Wang, Yongxiang
-
Du, Yifeng
-
Qiu, Chengxuan
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Geriatrics
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Other Medical an ...
-
and Gerontology spec ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
Journal of Alzhe ...
- By the university
-
Umeå University
-
Stockholm University
-
Karolinska Institutet