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Dynamics of urine p...
Dynamics of urine proteomics biomarker and disease progression in patients with IgA nephropathy
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- Peters, Björn (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Beige, Joachim (author)
- Kuratorium for Dialysis and Transplantation, Germany; Division of Nephrology, Rheumatology and Endocrinology, Martin-Luther University Halle-Wittenberg, Halle/Saale., Germany,Kuratorium Dialysis & Transplantat, Germany; Martin Luther Univ Halle Wittenberg, Germany
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- Siwy, Justyna (author)
- Mosaiques diagnostics GmbH, Hannover, Germany,Mosa Diagnost GmbH, Germany
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- Rudnicki, Michael (author)
- Department of Internal Medicine IV - Nephrology and Hypertension, Medical University Innsbruck, Innsbruck, Austria
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- Wendt, Ralph (author)
- Division of Nephrology and KfH Renal Unit, Hospital St Georg, Leipzig, Germany,Hosp St Georg, Germany; Hosp St Georg, Germany
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- Ortiz, Alberto (author)
- Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD UAM), Madrid, Spain
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- Sanz, Ana Belen (author)
- Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD UAM), Madrid, Spain
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- Mischak, Harald (author)
- Mosaiques diagnostics GmbH, Hannover, Germany,Mosa Diagnost GmbH, Germany
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- Reich, Heather N. (author)
- Department of Medicine, University of Toronto and Division of Nephrology, University Health Network, ON, Toronto, Canada; Gabor Zellerman Chair in Nephrology Research, University of Toronto, ON, Toronto, Canada,Univ Toronto, Canada; Univ Hlth Network, Canada; Univ Toronto, Canada
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- Nasic, Salmir (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för molekylär och klinisk medicin,Institute of Medicine, Department of Molecular and Clinical Medicine
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- Mahmood, Dana, 1965- (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Umea Univ, Sweden
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- Persson, Anders (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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- Fernström, Anders (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US,Umea Univ, Sweden
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- Weiner, Maria (author)
- Linköpings universitet,Avdelningen för diagnostik och specialistmedicin,Medicinska fakulteten,Region Östergötland, Njurmedicinska kliniken US
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- Stegmayr, Bernd, 1949- (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Umea Univ, Sweden
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(creator_code:org_t)
- Oxford University Press, 2023
- 2023
- English.
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In: Nephrology, Dialysis and Transplantation. - : Oxford University Press. - 0931-0509 .- 1460-2385. ; 38:12, s. 2826-2834
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Abstract
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- Background: Immunoglobulin A nephropathy (IgAN) frequently leads to kidney failure. The urinary proteomics-based classifier IgAN237 may predict disease progression at the time of kidney biopsy. We studied whether IgAN237 also predicts progression later in the course of IgAN.Methods: Urine from patients with biopsy-proven IgAN was analyzed using capillary electrophoresis-mass spectrometry at baseline (IgAN237-1, n = 103) and at follow-up (IgAN237-2, n = 89). Patients were categorized as "non-progressors" (IgAN237 ≤0.38) and "progressors" (IgAN237 >0.38). Estimated glomerular filtration rate (eGFR) and urinary albumin-creatinine ratio slopes were calculated.Results: Median age at biopsy was 44 years, interval between biopsy and IgAN237-1 was 65 months and interval between IgAN237-1 and IgAN237-2 was 258 days (interquartile range 71-531). IgAN237-1 and IgAN237-2 values did not differ significantly and were correlated (rho = 0.44, P < .001). Twenty-eight percent and 26% of patients were progressors based on IgAN237-1 and IgAN237-2, respectively. IgAN237 inversely correlated with chronic eGFR slopes (rho = -0.278, P = .02 for score-1; rho = -0.409, P = .002 for score-2) and with ±180 days eGFR slopes (rho = -0.31, P = .009 and rho = -0.439, P = .001, respectively). The ±180 days eGFR slopes were worse for progressors than for non-progressors (median -5.98 versus -1.22 mL/min/1.73 m2 per year for IgAN237-1, P < .001; -3.02 vs 1.08 mL/min/1.73 m2 per year for IgAN237-2, P = .0047). In multiple regression analysis baseline progressor/non-progressor according to IgAN237 was an independent predictor of eGFR180days-slope (P = .001).Conclusion: The urinary IgAN237 classifier represents a risk stratification tool in IgAN also later in the course of the dynamic disease. It may guide patient management in an individualized manner.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
Keyword
- biomarker
- CKD
- glomerulonephritis
- IgA nephropathy
- progression
- urine proteomics
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Peters, Björn
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Beige, Joachim
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Siwy, Justyna
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Rudnicki, Michae ...
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Wendt, Ralph
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Ortiz, Alberto
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Sanz, Ana Belen
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Mischak, Harald
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Reich, Heather N ...
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Nasic, Salmir
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Mahmood, Dana, 1 ...
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Persson, Anders
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Fernström, Ander ...
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Weiner, Maria
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Stegmayr, Bernd, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
- Articles in the publication
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Nephrology, Dial ...
- By the university
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Umeå University
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Linköping University
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University of Gothenburg