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Synthesis and characterization of a carbon nanotube−dendron series for efficient sirna delivery

Herrero, M. Antonia (author)
Center of Excellence for Nanostructured Materials, Department of Pharmaceutical Sciences, and INSTM, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy, Departamento de Química Orgánica, Facultad de Química, Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain, SISSA, 34014 Trieste, Italy, Nanomedicine Laboratory, Centre for Drug Delivery Research, The School of Pharmacy, University of London, London WC1N 1AX, U.K., CNRS, Institut de Biologie Moléculaire et Cellulaire, UPR9021...
Toma, Francesca M. (author)
Center of Excellence for Nanostructured Materials, Department of Pharmaceutical Sciences, and INSTM, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy, Departamento de Química Orgánica, Facultad de Química, Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain, SISSA, 34014 Trieste, Italy, Nanomedicine Laboratory, Centre for Drug Delivery Research, The School of Pharmacy, University of London, London WC1N 1AX, U.K., CNRS, Institut de Biologie Moléculaire et Cellulaire, UPR9021...
Al-Jamal, Khuloud T. (author)
Center of Excellence for Nanostructured Materials, Department of Pharmaceutical Sciences, and INSTM, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy, Departamento de Química Orgánica, Facultad de Química, Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain, SISSA, 34014 Trieste, Italy, Nanomedicine Laboratory, Centre for Drug Delivery Research, The School of Pharmacy, University of London, London WC1N 1AX, U.K., CNRS, Institut de Biologie Moléculaire et Cellulaire, UPR9021...
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Kostarelos, Kostas (author)
Center of Excellence for Nanostructured Materials, Department of Pharmaceutical Sciences, and INSTM, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy, Departamento de Química Orgánica, Facultad de Química, Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain, SISSA, 34014 Trieste, Italy, Nanomedicine Laboratory, Centre for Drug Delivery Research, The School of Pharmacy, University of London, London WC1N 1AX, U.K., CNRS, Institut de Biologie Moléculaire et Cellulaire, UPR9021...
Bianco, Alberto (author)
Center of Excellence for Nanostructured Materials, Department of Pharmaceutical Sciences, and INSTM, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy, Departamento de Química Orgánica, Facultad de Química, Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain, SISSA, 34014 Trieste, Italy, Nanomedicine Laboratory, Centre for Drug Delivery Research, The School of Pharmacy, University of London, London WC1N 1AX, U.K., CNRS, Institut de Biologie Moléculaire et Cellulaire, UPR9021...
Da Ros, Tatiana (author)
Center of Excellence for Nanostructured Materials, Department of Pharmaceutical Sciences, and INSTM, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy, Departamento de Química Orgánica, Facultad de Química, Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain, SISSA, 34014 Trieste, Italy, Nanomedicine Laboratory, Centre for Drug Delivery Research, The School of Pharmacy, University of London, London WC1N 1AX, U.K., CNRS, Institut de Biologie Moléculaire et Cellulaire, UPR9021...
Bano, Fouzia (author)
Center of Excellence for Nanostructured Materials, Department of Pharmaceutical Sciences, and INSTM, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy, Departamento de Química Orgánica, Facultad de Química, Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain, SISSA, 34014 Trieste, Italy, Nanomedicine Laboratory, Centre for Drug Delivery Research, The School of Pharmacy, University of London, London WC1N 1AX, U.K., CNRS, Institut de Biologie Moléculaire et Cellulaire, UPR9021...
Casalis, Loredana (author)
Center of Excellence for Nanostructured Materials, Department of Pharmaceutical Sciences, and INSTM, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy, Departamento de Química Orgánica, Facultad de Química, Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain, SISSA, 34014 Trieste, Italy, Nanomedicine Laboratory, Centre for Drug Delivery Research, The School of Pharmacy, University of London, London WC1N 1AX, U.K., CNRS, Institut de Biologie Moléculaire et Cellulaire, UPR9021...
Scoles, Giacinto (author)
Center of Excellence for Nanostructured Materials, Department of Pharmaceutical Sciences, and INSTM, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy, Departamento de Química Orgánica, Facultad de Química, Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain, SISSA, 34014 Trieste, Italy, Nanomedicine Laboratory, Centre for Drug Delivery Research, The School of Pharmacy, University of London, London WC1N 1AX, U.K., CNRS, Institut de Biologie Moléculaire et Cellulaire, UPR9021...
Prato, Maurizio (author)
Center of Excellence for Nanostructured Materials, Department of Pharmaceutical Sciences, and INSTM, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy, Departamento de Química Orgánica, Facultad de Química, Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain, SISSA, 34014 Trieste, Italy, Nanomedicine Laboratory, Centre for Drug Delivery Research, The School of Pharmacy, University of London, London WC1N 1AX, U.K., CNRS, Institut de Biologie Moléculaire et Cellulaire, UPR9021...
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Center of Excellence for Nanostructured Materials, Department of Pharmaceutical Sciences, and INSTM, University of Trieste, Piazzale Europa 1, 34127 Trieste, Italy, Departamento de Química Orgánica, Facultad de Química, Universidad de Castilla-La Mancha, 13071 Ciudad Real, Spain, SISSA, 34014 Trieste, Italy, Nanomedicine Laboratory, Centre for Drug Delivery Research, The School of Pharmacy, University of London, London WC1N 1AX, UK., CNRS, Institut de Biologie Moléculaire et Cellulaire, UPR9021... (creator_code:org_t)
2009-06-25
2009
English.
In: Journal of the American Chemical Society. - : American Chemical Society (ACS). - 0002-7863 .- 1520-5126. ; 131:28, s. 9843-9848
Related links:
https://urn.kb.se/re...
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https://doi.org/10.1...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • A new series of dendron-functionalized multiwalled carbon nanotube (MWNT) derivatives, characterized by the presence of numerous positively charged tetraalkyl ammonium salts at the periphery of the dendron, has been synthesized. The positive charges on the MWNT surface, coupled with the unique ability of carbon nanotubes (CNTs) to penetrate cell membranes, make the new derivatives potentially ideal vectors for siRNA delivery. Using a fluorescently labeled, noncoding siRNA sequence, we demonstrate that cytoplasmic delivery of the nucleic acid is remarkably increased throughout the different dendron generations. The work reported here highlights the fact that dendron-functionalized CNTs can be rationally designed as efficient carriers of siRNA that can eventually lead to gene silencing.

Subject headings

NATURVETENSKAP  -- Kemi -- Materialkemi (hsv//swe)
NATURAL SCIENCES  -- Chemical Sciences -- Materials Chemistry (hsv//eng)
NATURVETENSKAP  -- Kemi -- Organisk kemi (hsv//swe)
NATURAL SCIENCES  -- Chemical Sciences -- Organic Chemistry (hsv//eng)

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ref (subject category)
art (subject category)

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