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Organo-ptii complex...
Organo-ptii complexes for potent photodynamic inactivation of multi-drug resistant bacteria and the influence of configuration
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- Chong, Hui (author)
- Department of Chemical and Chemical Engineering, Yangzhou University, No. 180, Si-Wang-Ting Rd., Jiangsu, Yangzhou, China
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- Liu, Xuanwei (author)
- Department of Chemical and Chemical Engineering, Yangzhou University, No. 180, Si-Wang-Ting Rd., Jiangsu, Yangzhou, China
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- Fang, Siyu (author)
- Department of Chemical and Chemical Engineering, Yangzhou University, No. 180, Si-Wang-Ting Rd., Jiangsu, Yangzhou, China
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- Yang, Xiaofei (author)
- Department of Chemical and Chemical Engineering, Yangzhou University, No. 180, Si-Wang-Ting Rd., Jiangsu, Yangzhou, China
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- Zhang, Yuefei (author)
- Department of Emergency, Affiliated Hospital of Yangzhou University, Jiangsu, Yangzhou, China
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- Wang, Tianyi (author)
- Department of Chemical and Chemical Engineering, Yangzhou University, No. 180, Si-Wang-Ting Rd., Jiangsu, Yangzhou, China
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- Liu, Lin (author)
- School of Nursing, Yangzhou University, Yangzhou, China; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and, Treatment of Senile Diseases, No. 88 South University Rd., Yangzhou, China
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- Kan, Yinshi (author)
- School of Nursing, Yangzhou University, Yangzhou, China; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and, Treatment of Senile Diseases, No. 88 South University Rd., Yangzhou, China
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- Zhao, Yueqi (author)
- School of Nursing, Yangzhou University, Yangzhou, China; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and, Treatment of Senile Diseases, No. 88 South University Rd., Yangzhou, China
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- Fan, Hongying (author)
- Testing Center of Yangzhou University, No. 48 Wenhui East Rd., Yangzhou, China
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- Zhang, Jingqi (author)
- School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, China
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- Wang, Xiaoyu (author)
- School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing, China
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- Yao, Hang (author)
- Department of Chemical and Chemical Engineering, Yangzhou University, No. 180, Si-Wang-Ting Rd., Jiangsu, Yangzhou, China
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- Yang, Yi (author)
- Center Laboratory, Affiliated Hospital of Yangzhou University, Yangzhou, China
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- Gao, Yijian (author)
- College of Pharmaceutical Sciences, Soochow University, Suzhou, China
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- Zhao, Qi (author)
- College of Pharmaceutical Sciences, Soochow University, Suzhou, China
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- Li, Shengliang (author)
- College of Pharmaceutical Sciences, Soochow University, Suzhou, China
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- Plymoth, Martin (author)
- Umeå universitet,Institutionen för klinisk mikrobiologi,Westmead hospital, NSW, Sydney, Australia
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- Xi, Juqun (author)
- Department of Pharmacology, Institute of Translational Medicine, School of Medicine, Yangzhou University, Yangzhou, China; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and, Treatment of Senile Diseases, Yangzhou, China
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- Zhang, Yu (author)
- School of Nursing, Yangzhou University, Yangzhou, China; Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and, Treatment of Senile Diseases, No. 88 South University Rd., Yangzhou, China
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- Wang, Chengyin (author)
- Department of Chemical and Chemical Engineering, Yangzhou University, No. 180, Si-Wang-Ting Rd., Jiangsu, Yangzhou, China
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- Pang, Huan (author)
- Department of Chemical and Chemical Engineering, Yangzhou University, No. 180, Si-Wang-Ting Rd., Jiangsu, Yangzhou, China
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Department of Chemical and Chemical Engineering, Yangzhou University, No 180, Si-Wang-Ting Rd., Jiangsu, Yangzhou, China Department of Emergency, Affiliated Hospital of Yangzhou University, Jiangsu, Yangzhou, China (creator_code:org_t)
- John Wiley & Sons, 2024
- 2024
- English.
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In: Advanced Science. - : John Wiley & Sons. - 2198-3844. ; 11:14
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https://umu.diva-por... (primary) (Raw object)
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Abstract
Subject headings
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- PtII based organometallic photosensitizers (PSs) have emerged as novel potent photodynamic inactivation (PDI) reagents through their enhanced intersystem crossing (ISC) processes. Currently, few PtII PSs have been investigated as antibacterial materials, with relatively poor performances reported and with structure-activity relationships not well described. Herein, a pair of configurational isomers are reported of Bis-BODIPY (4,4-difluoro-boradizaindacene) embedded PtII PSs. The cis-isomer (cis-BBP) displayed enhanced 1O2 generation and better bacterial membrane anchoring capability as compared to the trans-isomer (trans-BBP). The effective PDI concentrations (efficiency > 99.9%) for cis-BBP in Acinetobacter baumannii (multi-drug resistant (MDR)) and Staphylococcus aureus are 400 nM (12 J cm−2) and 100 nM (18 J cm−2), respectively; corresponding concentrations and light doses for trans-BBP in the two bacteria are 2.50 µM (30 J cm−2) and 1.50 µM (18 J cm−2), respectively. The 50% and 90% minimum inhibitory concentration (MIC50 and MIC90) ratio of trans-BBP to cis-BBP is 22.22 and 24.02 in A. baumannii (MDR); 21.29 and 22.36 in methicillin resistant S. aureus (MRSA), respectively. Furthermore, cis-BBP displays superior in vivo antibacterial performance, with acceptable dark and photoinduced cytotoxicity. These results demonstrate cis-BBP is a robust light-assisted antibacterial reagent at sub-micromolecular concentrations. More importantly, configuration of PtII PSs should be an important issue to be considered in further PDI reagents design.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Keyword
- antibacterial agents
- drug resistance
- membrane anchoring
- photosensitizers
- PtII
- reactive oxygen species
- structure-activity relationship
Publication and Content Type
- ref (subject category)
- art (subject category)
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To the university's database
- By the author/editor
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Chong, Hui
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Liu, Xuanwei
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Fang, Siyu
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Yang, Xiaofei
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Zhang, Yuefei
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Wang, Tianyi
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show more...
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Liu, Lin
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Kan, Yinshi
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Zhao, Yueqi
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Fan, Hongying
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Zhang, Jingqi
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Wang, Xiaoyu
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Yao, Hang
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Yang, Yi
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Gao, Yijian
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Zhao, Qi
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Li, Shengliang
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Plymoth, Martin
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Xi, Juqun
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Zhang, Yu
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Wang, Chengyin
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Pang, Huan
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Infectious Medic ...
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Advanced Science
- By the university
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Umeå University