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Heart transplantati...
Heart transplantation and biomarkers : a review about their usefulness in clinical practice
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- Martini, L. (author)
- Department of Medical Biotechnology, University of Siena, Siena, Italy
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- Mandoli, G.E. (author)
- Department of Medical Biotechnology, University of Siena, Siena, Italy
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- Pastore, M.C. (author)
- Department of Medical Biotechnology, University of Siena, Siena, Italy
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- Pagliaro, A. (author)
- Cardio-Thoracic-Vascular Department, Siena University Hospital, Siena, Italy
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- Bernazzali, S. (author)
- Cardio-Thoracic-Vascular Department, Siena University Hospital, Siena, Italy
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- Maccherini, M. (author)
- Cardio-Thoracic-Vascular Department, Siena University Hospital, Siena, Italy
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- Henein, Michael Y. (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
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- Cameli, M. (author)
- Department of Medical Biotechnology, University of Siena, Siena, Italy
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(creator_code:org_t)
- Frontiers Media S.A. 2024
- 2024
- English.
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In: Frontiers in Cardiovascular Medicine. - : Frontiers Media S.A.. - 2297-055X. ; 11
- Related links:
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https://doi.org/10.3...
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Subject headings
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- Advanced heart failure (AdvHF) can only be treated definitively by heart transplantation (HTx), yet problems such right ventricle dysfunction (RVD), rejection, cardiac allograft vasculopathy (CAV), and primary graft dysfunction (PGD) are linked to a poor prognosis. As a result, numerous biomarkers have been investigated in an effort to identify and prevent certain diseases sooner. We looked at both established biomarkers, such as NT-proBNP, hs-troponins, and pro-inflammatory cytokines, and newer ones, such as extracellular vesicles (EVs), donor specific antibodies (DSA), gene expression profile (GEP), donor-derived cell free DNA (dd-cfDNA), microRNA (miRNA), and soluble suppression of tumorigenicity 2 (sST2). These biomarkers are typically linked to complications from HTX. We also highlight the relationships between each biomarker and one or more problems, as well as their applicability in routine clinical practice.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Keyword
- biomarker
- CAV
- heart transplantation
- PGD
- rejection
- RVD
Publication and Content Type
- ref (subject category)
- for (subject category)
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