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Association of anti...
Association of antidepressant and benzodiazepine use, and anticholinergic burden with cognitive performance in schizophrenia
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- Mäkipelto, Ville (author)
- Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland
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- Tuulio-Henriksson, Annamari (author)
- Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland
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- Hakulinen, Christian (author)
- Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Welfare State Research and Reform, Finnish Institute for Health and Welfare, Helsinki, Finland
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- Niemelä, Solja (author)
- Department of Psychiatry, University of Turku, Finland
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- Lähteenvuo, Markku (author)
- Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, Kuopio, Finland
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- Wegelius, Asko (author)
- Mental Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland; Department of Psychiatry, University of Helsinki, Finland
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- Kieseppä, Tuula (author)
- Mental Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland; Department of Psychiatry, University of Helsinki, Finland
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- Isometsä, Erkki (author)
- Department of Psychiatry, University of Helsinki, Finland
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- Tiihonen, Jari (author)
- Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Eastern Finland, Kuopio, Finland; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Center for Psychiatry Research, Stockholm City Council, Stockholm, Sweden
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- Kampman, Olli (author)
- Umeå universitet,Psykiatri,Department of Psychiatry, University of Turku, Finland; Tampere University, Faculty of Medicine and Health Technology, Tampere, Finland; The Pirkanmaa Wellbeing Services County, Department of Psychiatry, Tampere, Finland; The Wellbeing Services County of Ostrobothnia, Department of Psychiatry, Finland
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- Lahdensuo, Kaisla (author)
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Finland; Mehiläinen, Helsinki, Finland
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- Mazumder, Atiqul (author)
- Department of Psychiatry, University of Turku, Finland; Research Unit of Clinical Neuroscience, University of Oulu, Finland
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- Suvisaari, Jaana (author)
- Mental Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland
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- Holm, Minna (author)
- Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Mental Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland
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(creator_code:org_t)
- Elsevier, 2024
- 2024
- English.
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In: Schizophrenia Research. - : Elsevier. - 0920-9964 .- 1573-2509. ; 266, s. 118-126
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Abstract
Subject headings
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- Schizophrenia is characterized by cognitive impairment affecting everyday functioning. Earlier research has hypothesized that antidepressants may associate with better cognitive functioning, but results are mixed. This study explored the association between antidepressant use and cognitive performance in terms of reaction time and visual learning in a clinical sample. In addition, we examined benzodiazepine use and anticholinergic burden. Study participants were drawn from the SUPER-Finland cohort, collected among patients with psychotic illnesses in 2016–2018 throughout Finland (n = 10,410). The analysis included adults with a schizophrenia diagnosis (F20) and results from a cognitive assessment (n = 3365). Information about medications and psychosocial factors were gathered through questionnaire and interview. Cognitive performance was assessed with the Cambridge Neuropsychological Test Automated Battery (CANTAB) with two subtests measuring reaction time and visual learning. Almost 36 % of participants used at least one antidepressant. The use of antidepressants in general was not associated with performance in the reaction time and visual learning tasks. However, the use of SNRI antidepressants was associated with a faster reaction time. Benzodiazepine use and a higher anticholinergic burden were associated with poorer performance in both tests. The results strengthen earlier findings that there is no association between antidepressant use in general and cognitive performance in schizophrenia. However, the association of SNRI medications with a faster reaction time warrants further research. Moreover, the results suggest that more attention should be paid to the anticholinergic burden of the medications used by patients with schizophrenia, as well as avoiding continuous benzodiazepine use.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
Keyword
- Anticholinergic burden
- Antidepressants
- Benzodiazepines
- CANTAB
- Cognition
- Cognitive impairment
- Schizophrenia
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Mäkipelto, Ville
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Tuulio-Henriksso ...
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Hakulinen, Chris ...
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Niemelä, Solja
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Lähteenvuo, Mark ...
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Wegelius, Asko
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Kieseppä, Tuula
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Isometsä, Erkki
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Tiihonen, Jari
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Kampman, Olli
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Lahdensuo, Kaisl ...
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Mazumder, Atiqul
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Suvisaari, Jaana
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Holm, Minna
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Psychiatry
- Articles in the publication
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Schizophrenia Re ...
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Umeå University