Search: onr:"swepub:oai:DiVA.org:umu-222429" >
Lower bone strength...
Lower bone strength in young patients with Fontan circulation compared to controls
-
- Wikner, Anna (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
-
- Johansson, Karna, 1982- (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
-
- Enocson, Elin (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
-
show more...
-
- Sthen Bergdahl, Magne (author)
- Umeå universitet,Pediatrik
-
- Hansson, Lena (author)
- Umeå universitet,Pediatrik
-
- Rydberg, Annika (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin
-
- Sandberg, Camilla (author)
- Umeå universitet,Institutionen för folkhälsa och klinisk medicin,Avdelningen för fysioterapi
-
show less...
-
(creator_code:org_t)
- 2024
- 2024
- English.
-
In: Cardiology in the Young. - : Cambridge University Press. - 1047-9511 .- 1467-1107.
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://umu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Objectives: Previous reports indicate bone deficits in patients with Fontan circulation. However, the consequences of these deficits on bone strength and when these changes occur are unclear.Aim: To compare the tibial bone strength-strain index between young patients (6-19 years) with Fontan circulation and age- and sex-matched controls, and to determine strength-strain-index in subgroups of children (6-12 years) and adolescents (13-19 years) versus controls.Method: The tibia was examined with peripheral quantitative CT. Based on the assessed data, bone strength-strain index was calculated in the lateral and anterior-posterior directions.Results: Twenty patients with Fontan and twenty controls (mean age 13.0 ± 4.4 years; 50% females) were examined. Patients had a lower strength-strain index in the lateral direction compared to controls (808.4 ± 416.8mm3 versus 1162.5 ± 552.1mm3, p = 0.043). Subgroup analyses showed no differences regarding strength-strain index in children (6-12 years) with Fontan circulation compared to controls. However, the adolescents (13-19 years) with Fontan circulation had lower strength-strain indexes in both the lateral and anterior-posterior directions compared to controls (1041.4 ± 299.8mm3 versus 1596.4 ± 239.6mm3, p < 0.001, and 771.7 ± 192.4mm3 versus 1084.9 ± 215.0mm3, p = 0.004). When adjusted for height, there were differences between patients (6-19 years) and controls in strength-strain indexes in both the lateral and anterior-posterior directions. In subgroup analyses, the results remained robust.Conclusion: Young patients (6-19 years) with Fontan circulation have a lower strength-strain index in the tibia compared to controls. Subgroup analyses show that this deficit is mainly driven by the differences in adolescents (13-19 years), which might suggest that bone strength decreases with age.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- adolescents
- bone mineral content
- bone mineral density
- CHD
- children
- Strength-strain index
- total cavo-pulmonary connection
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database