Combined amniotic membrane and self-powered electrical stimulator bioelectronic dress promotes wound healing

Wang, Yupei (author): Gansu Provincial Maternity and Child-care Hospital (Gansu Provincial Central Hospital), Lanzhou, China

Wu, Han (author): Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China

Xiao, Ao (author): Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China

Zhu, Jing (author): College of Life Science, Northwest Normal University, Lanzhou, China

Qiu, Jie (author): Gansu Provincial Maternity and Child-care Hospital (Gansu Provincial Central Hospital), Lanzhou, China

Yang, Kuan (author): Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China

Liu, Qing (author): Gansu Provincial Maternity and Child-care Hospital (Gansu Provincial Central Hospital), Lanzhou, China

Hao, Shengju (author): Gansu Provincial Maternity and Child-care Hospital (Gansu Provincial Central Hospital), Lanzhou, China

Hui, Ling (author): Gansu Provincial Maternity and Child-care Hospital (Gansu Provincial Central Hospital), Lanzhou, China

Zhou, Xin (author): Umeå universitet,Institutionen för integrativ medicinsk biologi (IMB)

Hou, Qinzheng (author): College of Life Science, Northwest Normal University, Lanzhou, China

Su, Haixiang (author): Gansu Provincial Maternity and Child-care Hospital (Gansu Provincial Central Hospital), Lanzhou, China

Meng, Zhaoyan (author): Gansu Provincial Maternity and Child-care Hospital (Gansu Provincial Central Hospital), Lanzhou, China

Chang, Lingqian (author): Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China

(creator_code:org_t)

American Chemical Society (ACS), 2024
2024
English.
In: ACS Applied Materials and Interfaces. - : American Chemical Society (ACS). - 1944-8244 .- 1944-8252. ; 16:13, s. 15809-15818

Related links:: https://urn.kb.se/re...; show more...; https://doi.org/10.1...; show less...

Abstract Subject headings

Human amniotic membranes (hAMs) are widely used as wound management biomaterials, especially as grafts for corneal reconstruction due to the structure of the extracellular matrix and excellent biological properties. However, their fragile nature and rapid degradation rate hinder widespread clinical use. In this work, we engineered a novel self-powered electronic dress (E-dress), combining the beneficial properties of an amniotic membrane and a flexible electrical electrode to enhance wound healing. The E-dress displayed a sustained discharge capacity, leading to increased epidermal growth factor (EGF) release from amniotic mesenchymal interstitial stem cells. Live/dead staining, CCK-8, and scratch-wound-closure assays were performed in vitro. Compared with amniotic membrane treatment alone, the E-dress promoted cell proliferation and migration of mouse fibroblast cells and lower cytotoxicity. In a mouse full-skin defect model, the E-dress achieved significantly accelerated wound closure. Histological analysis revealed that E-dress treatment promoted epithelialization and neovascularization in mouse skin. The E-dress exhibited a desirable flexibility that aligned with tissue organization and displayed maximum bioactivity within a short period to overcome rapid degradation, implying great potential for clinical applications.

MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP -- Medicinsk bioteknologi -- Biomaterialvetenskap (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Medical Biotechnology -- Biomaterials Science (hsv//eng)

By the author/editor: Wang, Yupei; Wu, Han; Xiao, Ao; Zhu, Jing; Qiu, Jie; Yang, Kuan; show more...; Liu, Qing; Hao, Shengju; Hui, Ling; Zhou, Xin; Hou, Qinzheng; Su, Haixiang; Meng, Zhaoyan; Chang, Lingqian; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Cell and Molecul ...

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Medical Biotechn ...; and Biomaterials Sci ...

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