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A novel t(2;17) in transformation of essential thrombocythemia to acute myelocytic leukemia.
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- Lazarevic, Vladimir Lj (author)
- Umeå universitet,Medicin
- Tomin, Dragica (author)
- Jankovic, Gradimir M (author)
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- Antic, Darko (author)
- Dencic, Marija (author)
- Gotic, Mirjana (author)
- Boskovic, Darinka (author)
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- (creator_code:org_t)
- 2004
- 2004
- English.
- In: Cancer Genetics and Cytogenetics. - 0165-4608 .- 1873-4456. ; 148:1, s. 77-9
- Journal article (peer-reviewed)
Abstract
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- A transformation of essential thrombocythemia to acute myelocytic leukemia (AML), myelodysplastic syndrome, or agnogenic myelocytic metaplasia is a relatively rare event. It occurs in 1%-4.5% of all patients with either treated or untreated essential thrombocythemia. Cytogenetic changes in the transformation to AML are common. We report the case of a patient treated for essential thrombocythemia with hydroxyurea for 49 months. He developed AML with a t(2;17), which to our knowledge has not been described in the literature.
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