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Low-protein infant ...
Low-protein infant formula enriched with Alpha-lactalbumin during early infancy may reduce insulin resistance at 12 months : a follow-up of a randomized controlled trial
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- Tinghäll Nilsson, Ulrika (author)
- Lund University,Lunds universitet,Preventiv pediatrik,Forskargrupper vid Lunds universitet,Preventive Paediatrics,Lund University Research Groups
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- Lönnerdal, Bo (author)
- Department of Nutrition, University of California, Davis, CA 95616, USA
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- Hernell, Olle (author)
- Umeå University,Umeå universitet,Pediatrik
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- Kvistgaard, Anne Staudt (author)
- Arla Foods Ingredients Group P/S, Viby, Denmark
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- Jacobsen, Lotte Neergaard (author)
- Arla Foods Ingredients Group P/S, Viby, Denmark
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- Karlsland Åkeson, Pia (author)
- Lund University,Lunds universitet,Preventiv pediatrik,Forskargrupper vid Lunds universitet,Preventive Paediatrics,Lund University Research Groups
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(creator_code:org_t)
- MDPI, 2024
- 2024
- English.
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In: Nutrients. - : MDPI. - 2072-6643. ; 16:7
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Abstract
Subject headings
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- High protein intake during infancy results in accelerated early weight gain and potentially later obesity. The aim of this follow-up study at 12 months was to evaluate if modified low-protein formulas fed during early infancy have long-term effects on growth and metabolism. In a double-blinded RCT, the ALFoNS study, 245 healthy-term infants received low-protein formulas with either alpha-lactalbumin-enriched whey (α-lac-EW; 1.75 g protein/100 kcal), casein glycomacropeptide-reduced whey (CGMP-RW; 1.76 g protein/100 kcal), or standard infant formula (SF; 2.2 g protein/100 kcal) between 2 and 6 months of age. Breastfed (BF) infants served as a reference. At 12 months, anthropometrics and dietary intake were assessed, and serum was analyzed for insulin, C-peptide, and insulin-like growth factor 1 (IGF-1). Weight gain between 6 and 12 months and BMI at 12 months were higher in the SF than in the BF infants (p = 0.019; p < 0.001, respectively), but were not significantly different between the low-protein formula groups and the BF group. S-insulin and C-peptide were higher in the SF than in the BF group (p < 0.001; p = 0.003, respectively), but more alike in the low-protein formula groups and the BF group. Serum IGF-1 at 12 months was similar in all study groups. Conclusion: Feeding modified low-protein formula during early infancy seems to reduce insulin resistance, resulting in more similar growth, serum insulin, and C-peptide concentrations to BF infants at 6-months post intervention. Feeding modified low-protein formula during early infancy results in more similar growth, serum insulin, and C-peptide concentrations to BF infants 6-months post intervention, probably due to reduced insulin resistance in the low-protein groups.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
Keyword
- alpha-lactalbumin
- body mass index
- CGMP
- childhood obesity
- IGF-1
- infant formula
- infant growth
- infant nutrition
- insulin
- low-protein
- alpha-lactalbumin
- body mass index
- CGMP
- childhood obesity
- IGF-1
- infant formula
- infant growth
- infant nutrition
- insulin
- low-protein
Publication and Content Type
- ref (subject category)
- art (subject category)
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