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The gut commensal B...
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Holmberg, SandraUmeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Institutionen för molekylärbiologi (Medicinska fakulteten),Umeå Centre for Microbial Research (UCMR)
(author)
The gut commensal Blautia maintains colonic mucus function under low-fiber consumption through secretion of short-chain fatty acids
- Article/chapterEnglish2024
Publisher, publication year, extent ...
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Nature Publishing Group,2024
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LIBRIS-ID:oai:DiVA.org:umu-224120
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-224120URI
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https://doi.org/10.1038/s41467-024-47594-wDOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Beneficial gut bacteria are indispensable for developing colonic mucus and fully establishing its protective function against intestinal microorganisms. Low-fiber diet consumption alters the gut bacterial configuration and disturbs this microbe-mucus interaction, but the specific bacteria and microbial metabolites responsible for maintaining mucus function remain poorly understood. By using human-to-mouse microbiota transplantation and ex vivo analysis of colonic mucus function, we here show as a proof-of-concept that individuals who increase their daily dietary fiber intake can improve the capacity of their gut microbiota to prevent diet-mediated mucus defects. Mucus growth, a critical feature of intact colonic mucus, correlated with the abundance of the gut commensal Blautia, and supplementation of Blautia coccoides to mice confirmed its mucus-stimulating capacity. Mechanistically, B. coccoides stimulated mucus growth through the production of the short-chain fatty acids propionate and acetate via activation of the short-chain fatty acid receptor Ffar2, which could serve as a new target to restore mucus growth during mucus-associated lifestyle diseases.
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Feeney, Rachel H.Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten)(Swepub:umu)rafe0005
(author)
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Prasoodanan P.K, VishnuUmeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten)(Swepub:umu)vipr0013
(author)
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Puértolas Balint, FabiolaUmeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten)(Swepub:umu)fapu0002
(author)
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Singh, Dhirendra K.Umeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten)(Swepub:umu)dhku0005
(author)
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Wongkuna, SupapitUmeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten)(Swepub:umu)suwo0004
(author)
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Zandbergen, LotteUmeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten)
(author)
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Hauner, HansInstitute in Nutritional Medicine, TU Munich, Munich, Germany; TU Munich, School of Medicine, Munich, Germany
(author)
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Brandl, BeateZIEL Institute for Food and Health, TU Munich, Munich, Germany
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Nieminen, Anni I.Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
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Skurk, ThomasZIEL Institute for Food and Health, TU Munich, Munich, Germany
(author)
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Schröder, BjörnUmeå universitet,Molekylär Infektionsmedicin, Sverige (MIMS),Umeå Centre for Microbial Research (UCMR),Institutionen för molekylärbiologi (Medicinska fakulteten)(Swepub:umu)bjsc0005
(author)
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Umeå universitetMolekylär Infektionsmedicin, Sverige (MIMS)
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In:Nature Communications: Nature Publishing Group15:12041-1723
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