Expression of erythropoietin and its receptor in human renal cell carcinoma

Objective: To investigate the prognostic impact of erythropoietin (EPO) and EPO-receptor (EPO-R) expression in tumour as well as serum EPO in patients with renal cell carcinoma (RCC). Methods: Using immunohistochemistry, EPO and EPO-R were assessed in tissue microarrays from 195 RCCs. RCC type, TNM stage, nuclear grade, survival, EPO and haemoglobin (Hb) levels in blood were registered. Results: Strong expression of EPO and EPO-R in tumour tissue was found in 83 and 56%, respectively. EPO and EPO-R expression differed between RCC types. Serum EPO and blood Hb did not correlate to the expression of EPO or EPO-R. A positive correlation was found between the expression of EPO and EPO-R (p = 0.028). Survival was not related to tumour EPO, whereas strong EPO-R expression indicated a non-significantly worse prognosis. Serum EPO correlated positively to TNM stage and nuclear grade and negatively to survival. A multivariate analysis showed that TNM stage and nuclear grade were independent prognostic factors. Tumour EPO and EPO-R expression as well as serum EPO added no independent prognostic information. Conclusion: No correlation between EPO or EPO-R in tumour tissue and serum EPO or blood Hb was found. Neither EPO, EPO-R in tumour tissue nor serum EPO are independent prognostic factors.

Bergh, AndersUmeå universitet,Patologi(Swepub:umu)anbe0010 (author)
Grankvist, KjellUmeå universitet,Klinisk kemi(Swepub:umu)kjgr0002 (author)
Ljungberg, BörjeUmeå universitet,Urologi och andrologi(Swepub:umu)bolj0001 (author)
Rasmuson, TorgnyUmeå universitet,Onkologi(Swepub:umu)tora0001 (author)
Umeå universitetOnkologi (creator_code:org_t)

In:Tumor Biology: Springer Science and Business Media LLC30:2, s. 86-921010-42831423-0380

By the author/editor: Papworth, Karin, ...; Bergh, Anders; Grankvist, Kjell; Ljungberg, Börje; Rasmuson, Torgny

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cancer and Oncol ...

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