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Olfactory dysfuncti...
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Granvik, ChristofferUmeå universitet,Institutionen för klinisk mikrobiologi
(author)
Olfactory dysfunction as an early predictor for post-COVID condition at 1-year follow-up
- Article/chapterEnglish2024
Publisher, publication year, extent ...
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John Wiley & Sons,2024
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electronicrdacarrier
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LIBRIS-ID:oai:DiVA.org:umu-226169
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https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-226169URI
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https://doi.org/10.1002/brb3.3574DOI
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Language:English
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Summary in:English
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Subject category:ref swepub-contenttype
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Subject category:art swepub-publicationtype
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Background: Olfactory dysfunction together with neurological and cognitive symptoms are common after COVID-19. We aimed to study whether performance on olfactory and neuropsychological tests following infection predict post-COVID condition (PCC), persisting symptoms, and reduced health-related quality of life.Methods: Both hospitalized (N = 10) and non-hospitalized individuals (N = 56) were enrolled in this prospective cohort study. Participants were evaluated 1–3 months after infection with an olfactory threshold test and neuropsychological tests, which was used as predictors of PCC. A questionnaire outlining persisting symptoms and the validated instrument EuroQol five-dimension five-level for health-related quality of life assessment were used as outcome data 1 year after infection (N = 59). Principal component analysis was used to identify relevant predictors for PCC at 1 year.Results: Objectively assessed olfactory dysfunction at 1–3 months post infection, but not subjective olfactory symptoms, predicted post-COVID condition with reduced health-related quality of life (PCC+) at 1 year. The PCC+ group scored more often below the cut off for mild cognitive impairment on the Montreal Cognitive Assessment (61.5% vs. 21.7%) and higher on the Multidimensional Fatigue Inventory-20, compared to the group without PCC+.Conclusion: Our results indicate that objectively assessed, olfactory dysfunction is a predictor for PCC+. These findings underscore the importance of objective olfactory testing. We propose that olfactory screening in the early post-acute phase of COVID-19 infection might identify individuals that are at higher risk of developing long-term health sequalae.
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Andersson, SaraUmeå universitet,Institutionen för integrativ medicinsk biologi (IMB)(Swepub:umu)annsaa02
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Andersson, Linus,1979-Umeå universitet,Institutionen för psykologi(Swepub:umu)lisann01
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Brorsson, CamillaUmeå universitet,Institutionen för diagnostik och intervention(Swepub:umu)brca0001
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Forsell, Mattias N. E.Umeå universitet,Institutionen för klinisk mikrobiologi(Swepub:umu)mafo0173
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Ahlm, Clas,1956-Umeå universitet,Institutionen för klinisk mikrobiologi(Swepub:umu)clah0001
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Normark, JohanUmeå universitet,Institutionen för klinisk mikrobiologi(Swepub:umu)jono0053
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Edin, Alicia,1985-Umeå universitet,Institutionen för diagnostik och intervention(Swepub:umu)alalid03
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Umeå universitetInstitutionen för klinisk mikrobiologi
(creator_code:org_t)
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In:Brain and Behavior: John Wiley & Sons14:62162-3279
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Andersson, Sara
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Normark, Johan
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