Search: onr:"swepub:oai:DiVA.org:umu-227301" >
Aryl amino acetamid...
Aryl amino acetamides prevent Plasmodium falciparum ring development via targeting the lipid-transfer protein PfSTART1
-
- Dans, Madeline G. (author)
- Burnet Institute, VIC, Melbourne, Australia; Walter and Eliza Hall Institute, VIC, Parkville, Australia; Institute of Mental and Physical Health and Clinical Translation (IMPACT) and School of Medicine, Deakin University, VIC, Geelong, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia
-
- Boulet, Coralie (author)
- Burnet Institute, VIC, Melbourne, Australia; Department of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland
-
- Watson, Gabrielle M. (author)
- Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia
-
show more...
-
- Nguyen, William (author)
- Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia
-
- Dziekan, Jerzy M. (author)
- Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia
-
- Evelyn, Cindy (author)
- Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia
-
- Reaksudsan, Kitsanapong (author)
- Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia
-
- Mehra, Somya (author)
- Burnet Institute, VIC, Melbourne, Australia; Institute of Mental and Physical Health and Clinical Translation (IMPACT) and School of Medicine, Deakin University, VIC, Geelong, Australia
-
- Razook, Zahra (author)
- Burnet Institute, VIC, Melbourne, Australia; Institute of Mental and Physical Health and Clinical Translation (IMPACT) and School of Medicine, Deakin University, VIC, Geelong, Australia
-
- Geoghegan, Niall D. (author)
- Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia
-
- Mlodzianoski, Michael J. (author)
- Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia
-
- Goodman, Christopher Dean (author)
- School of Biosciences, The University of Melbourne, VIC, Parkville, Australia
-
- Ling, Dawson B. (author)
- Burnet Institute, VIC, Melbourne, Australia
-
- Jonsdottir, Thorey K. (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten),Burnet Institute, VIC, Melbourne, Australia; Department of Microbiology and Immunology, The University of Melbourne, VIC, Parkville, Australia; The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå, Sweden
-
- Tong, Joshua (author)
- Walter and Eliza Hall Institute, VIC, Parkville, Australia
-
- Famodimu, Mufuliat Toyin (author)
- Department of Infection Biology, Faculty of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
-
- Kristan, Mojca (author)
- Wellcome Trust Human Malaria Transmission Facility, Faculty of Infectious & amp; Tropical Diseases, London School of Hygiene & amp; Tropical Medicine, London, United Kingdom
-
- Pollard, Harry (author)
- Wellcome Trust Human Malaria Transmission Facility, Faculty of Infectious & amp; Tropical Diseases, London School of Hygiene & amp; Tropical Medicine, London, United Kingdom
-
- Stewart, Lindsay B. (author)
- Wellcome Trust Human Malaria Transmission Facility, Faculty of Infectious & amp; Tropical Diseases, London School of Hygiene & amp; Tropical Medicine, London, United Kingdom
-
- Brandner-Garrod, Luke (author)
- Wellcome Trust Human Malaria Transmission Facility, Faculty of Infectious & amp; Tropical Diseases, London School of Hygiene & amp; Tropical Medicine, London, United Kingdom
-
- Sutherland, Colin J. (author)
- Department of Infection Biology, Faculty of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom; Wellcome Trust Human Malaria Transmission Facility, Faculty of Infectious & amp; Tropical Diseases, London School of Hygiene & amp; Tropical Medicine, London, United Kingdom
-
- Delves, Michael J. (author)
- Department of Infection Biology, Faculty of Infectious Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
-
- McFadden, Geoffrey I. (author)
- School of Biosciences, The University of Melbourne, VIC, Parkville, Australia
-
- Barry, Alyssa E. (author)
- Burnet Institute, VIC, Melbourne, Australia; Institute of Mental and Physical Health and Clinical Translation (IMPACT) and School of Medicine, Deakin University, VIC, Geelong, Australia
-
- Crabb, Brendan S. (author)
- Burnet Institute, VIC, Melbourne, Australia; Department of Microbiology and Immunology, The University of Melbourne, VIC, Parkville, Australia; Monash University, VIC, Melbourne, Australia
-
- de Koning-Ward, Tania F. (author)
- Institute of Mental and Physical Health and Clinical Translation (IMPACT) and School of Medicine, Deakin University, VIC, Geelong, Australia
-
- Rogers, Kelly L. (author)
- Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia
-
- Cowman, Alan F. (author)
- Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia
-
- Tham, Wai-Hong (author)
- Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia
-
- Sleebs, Brad E. (author)
- Walter and Eliza Hall Institute, VIC, Parkville, Australia; Department of Medical Biology, The University of Melbourne, VIC, Parkville, Australia
-
- Gilson, Paul R. (author)
- Burnet Institute, VIC, Melbourne, Australia; Department of Microbiology and Immunology, The University of Melbourne, VIC, Parkville, Australia
-
show less...
-
(creator_code:org_t)
- Springer Nature, 2024
- 2024
- English.
-
In: Nature Communications. - : Springer Nature. - 2041-1723. ; 15:1
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://umu.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- With resistance to most antimalarials increasing, it is imperative that new drugs are developed. We previously identified an aryl acetamide compound, MMV006833 (M-833), that inhibited the ring-stage development of newly invaded merozoites. Here, we select parasites resistant to M-833 and identify mutations in the START lipid transfer protein (PF3D7_0104200, PfSTART1). Introducing PfSTART1 mutations into wildtype parasites reproduces resistance to M-833 as well as to more potent analogues. PfSTART1 binding to the analogues is validated using organic solvent-based Proteome Integral Solubility Alteration (Solvent PISA) assays. Imaging of invading merozoites shows the inhibitors prevent the development of ring-stage parasites potentially by inhibiting the expansion of the encasing parasitophorous vacuole membrane. The PfSTART1-targeting compounds also block transmission to mosquitoes and with multiple stages of the parasite’s lifecycle being affected, PfSTART1 represents a drug target with a new mechanism of action.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Dans, Madeline G ...
-
Boulet, Coralie
-
Watson, Gabriell ...
-
Nguyen, William
-
Dziekan, Jerzy M ...
-
Evelyn, Cindy
-
show more...
-
Reaksudsan, Kits ...
-
Mehra, Somya
-
Razook, Zahra
-
Geoghegan, Niall ...
-
Mlodzianoski, Mi ...
-
Goodman, Christo ...
-
Ling, Dawson B.
-
Jonsdottir, Thor ...
-
Tong, Joshua
-
Famodimu, Mufuli ...
-
Kristan, Mojca
-
Pollard, Harry
-
Stewart, Lindsay ...
-
Brandner-Garrod, ...
-
Sutherland, Coli ...
-
Delves, Michael ...
-
McFadden, Geoffr ...
-
Barry, Alyssa E.
-
Crabb, Brendan S ...
-
de Koning-Ward, ...
-
Rogers, Kelly L.
-
Cowman, Alan F.
-
Tham, Wai-Hong
-
Sleebs, Brad E.
-
Gilson, Paul R.
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Infectious Medic ...
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Cell and Molecul ...
- Articles in the publication
-
Nature Communica ...
- By the university
-
Umeå University